目的

了解毛囊干细胞 （HFSCs）在脱发领域的发文情况、研究热点及趋势分析，为今后脱发的预防及治疗研究提供参考。

方法

检索CNKI、CBM 和WOS 数据库近20 年HFSCs 在脱发领域相关文献作为分析对象，使用CiteSpace （6.2.R4）可视化软件对文献进行可视化分析。

结果

共纳入文献1 091 篇，其中中文文献235 篇，英文文献856 篇。英文文献发文量最多的国家是美国 （337 篇），其次分别是中国 （154 篇），英国 （98 篇），德国 （97 篇）和日本 （89 篇）。发文量最多的国外研究机构是加州大学系统 （44 篇）；国内研究机构是南方医科大学 （9 篇）。德国吕贝克大学的Paus Ralf 教授 （34 篇）是最高产的英文作者。中部战区总医院基础医学实验室的刁波教授 （7 篇）是最高产的中文作者。世界范围内该领域的关注度在不断攀升，国家和机构间合作密切，我国拥有重要的国际地位。高频关键词有“hair follicle”、“expression”、“differentiation”等。研究热点集中在信号通路介导的毛囊再生、生物打印技术的应用、毛囊免疫微环境稳态的维持以及传统的物理刺激和药物联合等方面研究。

结论

通过可视化分析得到毛囊干细胞在脱发领域的研究现状和热点趋势，为今后的临床科研工作提供有益的参考。

Objective

To understand the publication status， research hotspots， and trend analysis of hair follicle stem cells （HFSCs） in the field of hair loss， and to provide reference for future research on hair loss prevention and treatment.

Method

The visual analysis method was used to analyze the related literature of HFSCs in the field of hair loss based on CiteSpace （6.2.R4）software， which were searched in the database of CNKI， CBM and WOS.

Results

A total of 1 091 articles were included， including 235 Chinese articles and 856 English articles. The country with the highest number of English literature publications is the United States （337）， followed by China（154）， the United Kingdom （98）， Germany （97）， and Japan （89）. The foreign research institution with the highest number of publications is the University of California system （44 articles）； The domestic research institution is Southern Medical University （9 articles）. Professor Paus Ralf from the University of Lubeck in Germany （34 articles） is the most prolific English author. Professor Diao Bo from the Basic Medicine Laboratory of the Central Theater Command General Hospital（7 articles） is the most prolific Chinese author. The attention in this field is constantly increasing worldwide， and there is close cooperation between countries and institutions. China has an important international status. High frequency keywords include "hair follicle"， "expression"， "differentiation"，etc. The research hotspots focus on signal pathway mediated hair follicle regeneration， application of bioprinting technology， maintenance of hair follicle immune microenvironment homeostasis， and traditional physical stimulation and drug combination.

Conclusion

Through visual analysis， the research status and hot trends of hair follicle stem cells in the field of hair loss were obtained， which provided a useful reference for clinical research in the future.