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中华细胞与干细胞杂志(电子版)

中华细胞与干细胞杂志(电子版) ›› 2024, Vol. 14 ›› Issue (01) : 45 -50. doi: 10.3877/cma.j.issn.2095-1221.2024.01.007

综述

免疫细胞在肾脏缺血再灌注损伤修复中的作用研究进展
曹守青1, 来东2, 焦启龙3, 安哲昆4, 李修彬2,†()   
  1. 1. 075000　张家口，河北北方学院研究生院；100039　北京，解放军总医院第三医学中心泌尿外科医学部
    2. 100039　北京，解放军总医院第三医学中心泌尿外科医学部
    3. 100039　北京，解放军总医院第三医学中心泌尿外科医学部；300071　天津，南开大学医学院
    4. 030001　太原，山西医科大学基础医学院
  • 收稿日期:2023-10-24 出版日期:2024-02-01
  • 通信作者: 李修彬
  • 基金资助:
    国家自然科学基金青年科学基金(81802804); 军队医学科技青年培育计划孵化项目(19QNP060); 解放军总医院"优青"培育专项(2020-YQPY-006); 解放军总医院青年自主创新科学基金成长项目(22QNCZ029)

The role of immune cells in renal ischemia-reperfusion injury and repair

Shouqing Cao1, Dong Lai2, Qilong Jiao3, Zhekun An4, Xiubin Li2,†()   

  1. 1. College of Graduate, Hebei North University, Zhangjiakou 075000, China; Department of Urology, the Third Medical Center, Chinese PLA General Hospital, Beijing 100039, China
    2. Department of Urology, the Third Medical Center, Chinese PLA General Hospital, Beijing 100039, China
    3. Department of Urology, the Third Medical Center, Chinese PLA General Hospital, Beijing 100039, China; Medical School of Nankai University, Tianjin 300071, China
    4. School of Basic Medicine, Shanxi Medical University, Taiyuan 030001, China
  • Received:2023-10-24 Published:2024-02-01
  • Corresponding author: Xiubin Li
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曹守青, 来东, 焦启龙, 安哲昆, 李修彬. 免疫细胞在肾脏缺血再灌注损伤修复中的作用研究进展[J/OL]. 中华细胞与干细胞杂志(电子版), 2024, 14(01): 45-50.

Shouqing Cao, Dong Lai, Qilong Jiao, Zhekun An, Xiubin Li. The role of immune cells in renal ischemia-reperfusion injury and repair[J/OL]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2024, 14(01): 45-50.

急性肾损伤（AKI）是一种常见的临床综合征，我国住院人群AKI的发病率高达11.6%，AKI发生后容易进展为慢性肾病（CKD）甚至终末期肾病（ESRD）。缺血再灌注损伤（IRI）是AKI的主要病因之一。肾小管上皮细胞是IRI致AKI发生过程中受损的主要细胞类型，也是肾脏修复过程中细胞再生的主要细胞来源。在AKI发生发展以及损伤修复的过程中，免疫细胞能够调节肾小管上皮细胞的损伤、增殖以及再上皮化等多种生物过程，最终导致AKI的不同结局。本文就IRI导致的AKI发生过程中免疫细胞发挥的作用以及领域内的挑战和发展作一综述。

关键词: 肾小管上皮细胞, 免疫细胞, 肾脏缺血再灌注, 肾脏损伤修复

Acute kidney injury (AKI) is a common clinical syndrome. The total incidence of AKI in hospitalized population in China is as high as 11.6%, and the occurrence of AKI is easy to progress to chronic kidney disease (CKD) and even end-stage renal disease (ESRD) . Ischemia-reperfusion injury (IRI) is one of the major causes of AKI. Renal tubular epithelial cells are the main cell types damaged in the process of IRI induced AKI, and also the main cell source of cell regeneration in the process of kidney repair. During the development and repair of AKI, immune cells regulate the damage, proliferation and re-epithelialization of renal tubular epithelial cells and other biological processes, which eventually lead to different outcomes of AKI. In this paper, the role of immune cells in the process of AKI induced by IRI and the challenges and developments in the field are reviewed.

Key words: Acute kidney injury, Immune cells, Renal ischemia/reperfusion, Renal injury and repair
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