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中华细胞与干细胞杂志(电子版) ›› 2021, Vol. 11 ›› Issue (02) : 125 -128. doi: 10.3877/cma.j.issn.2095-1221.2021.02.009

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综述

树突状表皮T细胞在胸腺内发育的研究进展
李雅舒1, 张小容2, 胡晓红2, 黄勇2, 罗高兴2, 贺伟峰2,()   
  1. 1. 200011 上海交通大学医学院附属第九人民医院整复外科;400038 重庆,陆军军医大学 (第三军医大学)第一附属医院全军烧伤研究所,创伤、烧伤与复合伤国家重点实验室,重庆市疾病蛋白质组学重点实验室
    2. 400038 重庆,陆军军医大学 (第三军医大学)第一附属医院全军烧伤研究所,创伤、烧伤与复合伤国家重点实验室,重庆市疾病蛋白质组学重点实验室
  • 收稿日期:2020-04-21 出版日期:2021-04-01
  • 通信作者: 贺伟峰
  • 基金资助:
    国家自然科学基金青年科学基金(32000645)

Development of dendritic epidermal T cells in thymus

Yashu Li1, Xiaorong Zhang2, Xiaohong Hu2, Yong Huang2, Gaoxing Luo2, Weifeng He2,()   

  1. 1. Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China; Institute of Burn Research, State Key Laboratory of Trauma, Burn and Combined Injury, Key Laboratory of Disease Proteomics of Chongqing, Southwest Hospital, Third Military Medical University (Army Medical Un 0iversity), Chongqing 400038, China
    2. Institute of Burn Research, State Key Laboratory of Trauma, Burn and Combined Injury, Key Laboratory of Disease Proteomics of Chongqing, Southwest Hospital, Third Military Medical University (Army Medical Un 0iversity), Chongqing 400038, China
  • Received:2020-04-21 Published:2021-04-01
  • Corresponding author: Weifeng He
引用本文:

李雅舒, 张小容, 胡晓红, 黄勇, 罗高兴, 贺伟峰. 树突状表皮T细胞在胸腺内发育的研究进展[J]. 中华细胞与干细胞杂志(电子版), 2021, 11(02): 125-128.

Yashu Li, Xiaorong Zhang, Xiaohong Hu, Yong Huang, Gaoxing Luo, Weifeng He. Development of dendritic epidermal T cells in thymus[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2021, 11(02): 125-128.

树突状表皮T淋巴细胞(DETC),特异性分布在表皮组织内,在皮肤免疫监视,皮肤伤面愈合中发挥重要作用。小鼠DETC发育仅涉及胚胎14.5 ~ 18 d这一短暂时间窗,而后则不再产生这类细胞。本综述拟从DETC T细胞受体(TCR)基因重排特点及调控机制,DETC在胸腺中的阳性选择及调控机制等方面进行论述,以期对DETC发育的时空特异性有一个系统性的认识。

DETC (Dendritic Epidermal T Cells) are a subset of γδ T cells, and specifically distributed in epidermal tissue. DETC play a vital role in skin immune surveillance and promote wound healing. Murine DETC only development in embryonic 14.5 day to 18 day, possessing obvious temporal specificity. As aimed to provide systemic view on spatiotemporal specificity of DETC development, this review focused on the characteristics and mechanisms of temporal specific DETC TCR rearrangement, and the features and regulatory mechanisms of positive selection of DETC.

图1 胎鼠胸腺DETC发育示意图
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