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中华细胞与干细胞杂志(电子版) ›› 2020, Vol. 10 ›› Issue (06) : 378 -382. doi: 10.3877/cma.j.issn.2095-1221.2020.06.011

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综述

DETC在创面愈合过程中对炎症反应的调控作用及机制研究进展
陈成1, 胡晓红1, 梁光萍1, 贺伟峰1,()   
  1. 1. 400038 重庆,陆军军医大学 (第三军医大学)第一附属医院全军烧伤研究所创伤、烧伤与复合伤国家重点实验室 重庆市疾病蛋白质组学重点实验室
  • 收稿日期:2020-02-29 出版日期:2020-12-01
  • 通信作者: 贺伟峰
  • 基金资助:
    国家自然科学基金面上项目(31872742); 军队医学科技青年培育计划(20QNPY024)

Research advances in the regulatory impact of DETC on inflammatory stage in wound healing and mechanism thereof

Cheng Chen1, Xiaohong Hu1, Guangping Liang1, Weifeng He1,()   

  1. 1. State Key Laboratory of Trauma, Burns, and Combined Injury, Institute of Burn Research, the First Affiliated Hospital of Army Medical University (the Third Military Medical University), Chongqing Key Laboratory for Disease Proteomics, Chongqing 400038, China
  • Received:2020-02-29 Published:2020-12-01
  • Corresponding author: Weifeng He
  • About author:
    Corresponding authors:He Weifeng, Email:
引用本文:

陈成, 胡晓红, 梁光萍, 贺伟峰. DETC在创面愈合过程中对炎症反应的调控作用及机制研究进展[J]. 中华细胞与干细胞杂志(电子版), 2020, 10(06): 378-382.

Cheng Chen, Xiaohong Hu, Guangping Liang, Weifeng He. Research advances in the regulatory impact of DETC on inflammatory stage in wound healing and mechanism thereof[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2020, 10(06): 378-382.

创面修复过程中的炎症反应对创面愈合既有促进作用也有抑制作用。适度的炎症反应有助于免疫防御的启动和各种生长因子的产生,过度的炎症反应则会导致瘢痕组织过度增生及机体的组织损伤。树突状表皮T淋巴细胞(DETC)起源于小鼠的胸腺后定殖于表皮并特异性地表达Vγ3Vδ1 T淋巴细胞受体(TCR)。其在创面愈合过程中不仅可以通过释放各种趋化因子和促炎因子扩大炎症反应,还有可能通过抗炎介质缓解机体的过度炎症反应从而促进创面愈合。

Inflammatory response can not only promote but also inhibit wound healing. Moderate inflammatory response is beneficial to the initiation of an immune response and the production of various growth factors. However, excessive inflammatory response will lead to hyperplastic scars and tissue injury in the body. Dendritic epidermal T lymphocytes (DETCs) , which specifically express the Vγ3δ1TCR, are originated from the thymus of mice and then colonized on the epidermis. In the process of wound healing, DETCs can not only exacerbate the inflammatory response by releasing various chemokines and pro-inflammatory factors, but also alleviate the excessive inflammatory response of the body through anti-inflammatory mediators to promote wound healing.

图1 DETC对创面愈合炎症反应的调控机制
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