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中华细胞与干细胞杂志(电子版)

中华细胞与干细胞杂志(电子版) ›› 2018, Vol. 08 ›› Issue (04) : 229 -233. doi: 10.3877/cma.j.issn.2095-1221.2018.04.007

所属专题： 文献；

综述

人脐带间充质干细胞移植治疗脊髓损伤的研究进展
陈奇1, 孙翊夫1, 吕晓霞2, 张福强3, 顾锐1, 高旭1, 邵立伟1, 姜金兰4,†()   
  1. 1. 130033　长春，吉林大学中日联谊医院骨科
    2. 250021　济南，山东附属省立医院中心实验室
    3. 130033　长春，吉林大学中日联谊医院科学研究中心
    4. 130033　长春，吉林大学中日联谊医院骨科；130033　长春，吉林大学中日联谊医院科学研究中心
  • 收稿日期:2018-04-10 出版日期:2018-08-01
  • 通信作者: 姜金兰

Progress of human umbilical cord mesenchymal stem cell transplantation for spinal cord injury

Qi Chen1, Yifu Sun1, Xiaoxia Lyu2, Fuqiang Zhang3, Rui Gu1, Xu Gao1, Liwei Shao1, Jinlan Jiang4,†()   

  1. 1. Department of Orthopedic Surgery, China-Japan Union Hospital, Jilin University, Changchun 130033, China
    2. Central Laboratory of Shandong Provincial Hospital, Jinan 250021, China
    3. Scientific Research Center, China-Japan Union Hospital, Jilin University, Changchun 130033, China
    4. Department of Orthopedic Surgery, China-Japan Union Hospital, Jilin University, Changchun 130033, China; Scientific Research Center, China-Japan Union Hospital, Jilin University, Changchun 130033, China
  • Received:2018-04-10 Published:2018-08-01
  • Corresponding author: Jinlan Jiang
  • About author:
    Corresponding author:Jiang Jinlan, Email:
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引用本文：

陈奇, 孙翊夫, 吕晓霞, 张福强, 顾锐, 高旭, 邵立伟, 姜金兰. 人脐带间充质干细胞移植治疗脊髓损伤的研究进展[J/OL]. 中华细胞与干细胞杂志(电子版), 2018, 08(04): 229-233.

Qi Chen, Yifu Sun, Xiaoxia Lyu, Fuqiang Zhang, Rui Gu, Xu Gao, Liwei Shao, Jinlan Jiang. Progress of human umbilical cord mesenchymal stem cell transplantation for spinal cord injury[J/OL]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2018, 08(04): 229-233.

脊髓损伤（SCI）由于复杂病理生理和神经修复再生困难，至今仍旧是难以攻克的医学难题，而干细胞因其神经再生和神经保护特性被认为是治疗SCI最有希望的方法。其中人脐带间充质干细胞（HUC-MSCs）近年培养分化方法不断改进、神经修复机制初步阐明，联合移植等综合治疗方案也不断实践，使HUC-MSCs移植治疗效果提高。另外关于HUC-MSCs治疗SCI的临床试验逐渐开展，术后患者神经功能恢复改善且无严重并发症出现，表明干细胞移植应用于人体是安全有效的。本文就HUC-MSCs治疗SCI的研究状况及进展进行综述。

关键词: 脊髓损伤, 人脐带间充质干细胞, 细胞移植, 联合治疗

Spinal cord injury (SCI) is still a difficult problem because of its complex pathophysiology. Stem cell transplantation are considered as the most promising treatment for SCI due to their nerve regeneration and neuroprotective effect. The methods of human umbilical cord mesenchymal stem cell (HUC-MSC) culture and differentiation have been improved. Moreover, the mechanism of neural repair has been preliminarily clarified. Combination therapy and other comprehensive treatment have improved the effect of stem cell transplantation. In addition, several clinical trials on stem cell therapy are on the way. HUC-MSCs transplantation can significantly improve the neurological function of patients without serious complications, indicating that stem cell therapy is safe and effective in human. This review summarizes and discusses recent advances on HUC-MSCs therapy for SCI.

Key words: Spinal cord injury, Human umbilical cord mesenchymal stem cells, Cell transplantation, Combination therapy
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