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中华细胞与干细胞杂志(电子版) ›› 2018, Vol. 08 ›› Issue (03) : 182 -186. doi: 10.3877/cma.j.issn.2095-1221.2018.03.011

所属专题: 文献

综述

极小胚胎样干细胞研究进展
徐峰波1, 崔光晶1, 刘倩1, 王肇光1, 曹启龙1   
  1. 1. 250101 济南,银丰生物工程集团有限公司
    2. 250101 济南,山东省脐带血造血干细胞库
  • 收稿日期:2017-12-13 出版日期:2018-06-01

New progress in very small embryonic-like stem cell research

Fengbo Xu1, Guangjing Cui1, Qian Liu1, Zhaoguang Wang1, Qilong Cao1   

  1. 1. YinFeng Biological Group, Jinan 250101, China
    2. ShanDong Cord Blood Bank, Jinan 250101, China
  • Received:2017-12-13 Published:2018-06-01
  • About author:
    Corresponding author: Li Dong, Email:
引用本文:

徐峰波, 崔光晶, 刘倩, 王肇光, 曹启龙. 极小胚胎样干细胞研究进展[J]. 中华细胞与干细胞杂志(电子版), 2018, 08(03): 182-186.

Fengbo Xu, Guangjing Cui, Qian Liu, Zhaoguang Wang, Qilong Cao. New progress in very small embryonic-like stem cell research[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2018, 08(03): 182-186.

成体干细胞较胚胎干细胞在获得和临床应用方面越来越显示独特的优势,极小胚胎样干细胞(VSELs)是一种具备多能干细胞(PSCs)特性的成体干细胞,已证实可以从多种成体器官中分离获得并在体内外实验研究中取得较大进步。本文就VSELs的发现、生物学特征、分离与培养分化、潜在应用以及目前研究面临的问题作简明阐述,以起到对VSELs的研究成果及现状的总结,并为今后VSELs的进一步深入研究和临床应用研究提供宝贵的材料。

Adult stem cells show more and more unique advantages in obtaining and clinical applications over embryonic stem cells. Very small embryonic-like stem cells (VSELs), a kind of adult stem cells with the characteristics of pluripotent stem cells, have been confirmed that they can be isolated from a variety of adult organs, and great progress of VSELs had been made in applications in vivo or in vitro. This review summarizes the recent studies on the VSEL, such as its discovery, biological characteristics, isolation and cultivation in vitro, potential applications and description of the problems the research being faced. It is hoped that the future research and clinical application of VSELs will be prompted.

图1 小鼠骨髓VSELs的流式细胞术经典分选策略图[14]
图2 VSELs多能分化与其他PSCs的关系推测[22]
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