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中华细胞与干细胞杂志(电子版) ›› 2018, Vol. 08 ›› Issue (01) : 59 -62. doi: 10.3877/cma.j.issn.2095-1221.2018.01.011

所属专题: 文献

综述

骨髓间充质干细胞向肝细胞分化的相关细胞因子及信号通路的研究进展
陈嘉成1, 傅念1,(), 黄幼姣1, 全宏军1   
  1. 1. 421002 衡阳,南华大学附属南华医院消化内科
  • 收稿日期:2018-01-01 出版日期:2018-02-01
  • 通信作者: 傅念
  • 基金资助:
    湖南省自然科学基金(2016JJ3107)

Current studies on cytokines and signal pathways involved in bone marrow mesenchymal stem cells differentiation into hepatocytes cells

Jiacheng Chen1, Nian Fu1,(), Youjiao Huang1, Hongjun Quan1   

  1. 1. Department of Gastroenterology, Affiliated Nanhua Hospital, University of South China, Hengyang 421002, China
  • Received:2018-01-01 Published:2018-02-01
  • Corresponding author: Nian Fu
  • About author:
    Corresponding author:Fu Nian, Email:
引用本文:

陈嘉成, 傅念, 黄幼姣, 全宏军. 骨髓间充质干细胞向肝细胞分化的相关细胞因子及信号通路的研究进展[J]. 中华细胞与干细胞杂志(电子版), 2018, 08(01): 59-62.

Jiacheng Chen, Nian Fu, Youjiao Huang, Hongjun Quan. Current studies on cytokines and signal pathways involved in bone marrow mesenchymal stem cells differentiation into hepatocytes cells[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2018, 08(01): 59-62.

骨髓干细胞包括造血干细胞(HSCs)和间充质干细胞(MSCs),骨髓间充质干细胞(BMSCs)是一类具有自我更新、增殖和多向分化能力的细胞,具有不对称分裂和无限增殖的特点。在肝细胞生长因子(HGF)的作用下,BMSCs可以分化为肝细胞,参与诱导这一分化过程的相关信号通路包括NF-kB信号通路、Notch信号通路、MAPK信号通路、Wnt信号通路和STAT3信号通路。文章主要就BMSCs分化为肝细胞的相关信号通路进行了综述。

Bone marrow stem cells include hematopoietic stem cells and mesenchymal stem cells. Bone marrow mesenchymal stem cells (BMSCs) are a kind of cells with properties of self-renewal, proliferation and multi-directional differentiation, and have the characteristic of asymmetric cell division and unlimited proliferation. Under the influences of hepatocyte growth factor (HGF), BMSCs can differentiate into liver cells, and related signaling pathways involved in the differentiation process include NF-kB signal pathways, Notch signal pathways, MAPK signal pathways, Wnt signal pathways and STAT3 signal pathways. The related signaling pathways of BMSCs differentiation into hepatocytes are reviewed in this article.

1
李睿,董红丽,刘汝斌, 等. 骨髓间充质干细胞移植可促进移植胰岛周围新生血管形成[J]. 器官移植, 2017, 8(2):149-153, 160.
2
Kang JG, Park SB, Seo MS, et al. Characterization and clinical application of mesenchymal stem cells from equine umbilical cord blood[J]. J Vet Sci, 2013, 14(3):367-371.
3
李乔乔,吴振强,张丽君. 骨髓间充质干细胞的定向分化潜能[J]. 中国组织工程研究, 2017, 21(25):4085-4090.
4
尉大为,葛锌雨,刘奕含, 等. 松果菊苷诱导骨髓间充质干细胞向成骨细胞分化的研究[J]. 中药药理与临床, 2017, 33(02):48-52.
5
Asama H, Suzuki T, Kita E, et al. [Nonalcoholic steatohepatitis after pancreatoduodenectomy with rapid progression of hepatic fibrosis: a case report][J]. Nihon Shokakibyo Gakkai Zasshi, 2015, 112(5):905-913.
6
Bihari C, Anand L, Rooge S, et al. Bone marrow stem cells and their niche components are adversely affected in advanced cirrhosis of the liver[J]. Hepatology, 2016, 64(4):1273-1288.
7
郑盛,杨涓,刘琼, 等. 经肝固有动脉自体骨髓间充质干细胞移植治疗失代偿期肝硬化的疗效及安全性[J]. 肝脏, 2016, 21(02):95-99.
8
谢树才,张剑权,蒋锡丽, 等. 骨髓间充质干细胞诱导分化为肝细胞的方法及机制研究与进展[J]. 中国组织工程研究[J], 2016, 20(50): 7586-7593.
9
Wang X, Zhen L, Miao H, et al. Concomitant retrograde coronary venous infusion of basic fibroblast growth factor enhances engraftment and differentiation of bone marrow mesenchymal stem cells for cardiac repair after myocardial infarction[J]. Theranostics, 2015, 5(9):995-1006.
10
Presta M, Chiodelli P, Giacomini A, et al. Fibroblast growth factors (FGFs) in cancer: FGF traps as a new therapeutic approach[J].Pharmacol Ther, 2017, 179:171-187.
11
Obaid R, Wani SE, Azfer A, et al. Optineurin negatively regulates osteoclast differentiation by modulating NF-κB and interferon signaling:implications for paget's disease[J]. Cell Rep, 2015, 13(6): 1096-1102.
12
Hess K, Ushmorov A, Fiedler J, et al. TNFalpha promotes osteogenic differentiation of human mesenchymal stem cells by triggering the NF-kappaB signaling pathway[J]. Bone, 2009, 45(2):367-376.
13
Valente MM, Allen M, Bortolotto V,et al. The MMP-1/PAR-1 axis enhances proliferation and neuronal differentiation of adult hippocampal neural progenitor cells[J]. Neural Plast, 2015, 2015: 646595.
14
Cho HH, Shin KK, Kim YJ,et al. NF-kappaB activation stimulates osteogenic differentiation of mesenchymal stem cells derived from human adipose tissue by increasing TAZ expression[J]. J Cell Physiol, 2010, 223(1):168-177.
15
Yang T, Wang Y, Jiang S, et al. Hepatocyte growth factor-induced differentiation of bone mesenchymal stem cells toward hepatocyte-like cells occurs through nuclear factor-kappa B signaling in vitro[J]. Cell Biol Int, 2016, 40(9):1017-1023.
16
Han D, Wu G, Chang C,et al. Disulfiram inhibits TGF-β-induced epithelial-mesenchymal transition and stem-like features in breast cancer via ERK/NF-κB/Snail pathway[J]. Oncotarget, 2015, 6(38): 40907-40919.
17
Takebe N, Harris PJ, Warren RQ, et al. Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways[J]. Nat Rev Clin Oncol, 2011, 8(2):97-106.
18
Lampreia FP, Carmelo JG, Anjos-Afonso F. Notch Signaling in the Regulation of Hematopoietic Stem Cell[J]. Curr Stem Cell Rep, 2017, 3(3):202-209.
19
Penton AL, Leonard LD, Spinner NB. Notch signaling in human development and disease[J]. Semin Cell Dev Biol, 2012, 23(4):450-457.
20
Radtke F, MacDonald HR, Tacchini-Cottier F. Regulation of innate and adaptive immunity by Notch[J]. Nat Rev Immunol, 2013, 13(6):427-437.
21
Tang Z, Wei J, Yu Y, et al. γ-Secretase inhibitor reverts the Notch signaling attenuation of osteogenic differentiation in aged bone marrow mesenchymal stem cells[J]. Cell Biol Int, 2016, 40(4):439-447.
22
Ke Z, Mao X, Li S, et al. Dynamic expression characteristics of Notch signal in bone marrow-derived mesenchymal stem cells during the process of differentiation into hepatocytes[J]. Tissue Cell, 2013, 45(2): 95-100.
23
Zhen Y, Zhang W, Liu C, et al. Exogenous hydrogen sulfide promotes C6 glioma cell growth through activation of the p38 MAPK/ERK1/2-COX-2 pathways[J]. Oncol Rep, 2015, 34(5):2413-2422.
24
Im NK, Jang WJ, Jeong CH, et al. Delphinidin suppresses PMA-induced MMP-9 expression by blocking the NF-κB activation through MAPK signaling pathways in MCF-7 human breast carcinoma cells[J]. J Med Food, 2014, 17(8):855-861.
25
Haspula D, Clark MA. MAPK activation patterns of AT1R and CB1R in SHR versus Wistar astrocytes: Evidence of CB1R hypofunction and crosstalk between AT1R and CB1R[J]. Cell Signal, 2017, 40:81-90.
26
Zhang B, Wu T, Wang Z, et al. p38MAPK activation mediates tumor necrosis factor-α-induced apoptosis in glioma cells[J]. Mol Med Rep, 2015, 11(4):3101-3107.
27
Zhang A, Wang Y, Ye Z, et al. Mechanism of TNF-α-induced migration and hepatocyte growth factor production in human mesenchymal stem cells[J]. J Cell Biochem, 2010, 111(2):469-475.
28
Li J, Zhao Z, Liu J, et al. MEK/ERK and p38 MAPK regulate chondrogenesis of rat bone marrow mesenchymal stem cells through delicate interaction with TGF-beta1/Smads pathway[J]. Cell Prolif, 2010, 43(4):333-343.
29
Lu T, Yang C, Sun H, et al. FGF4 and HGF promote differentiation of mouse bone marrow mesenchymal stem cells into hepatocytes via the MAPK pathway[J]. Genet Mol Res, 2014, 13(1):415-424.
30
Mohammed MK, Shao C, Wang J, et al. Wnt/β-catenin signaling plays an ever-expanding role in stem cell self-renewal, tumorigenesis and cancer chemoresistance. Genes Dis. 2016. 3(1): 11-40.
31
Clevers H, Nusse R. Wnt/β-catenin signaling and disease. Cell. 2012. 149(6): 1192-205.
32
张遥,任秀智,韩金祥, 等. Wnt信号通路与人类疾病相关性的研究进展[J]. 中国生物制品学杂志, 2018, (1):81-86.
33
Zhang H, Chen J, Shen Z, et al. Indoxyl sulfate accelerates vascular smooth muscle cell calcification via microRNA-29b dependent regulation of Wnt/β-catenin signaling[J]. Toxicol Lett, 2017, 284:29-36.
34
Lin CM, Yuan YP, Chen XC, et al. Expression of Wnt/β-catenin signaling, stem-cell markers and proliferating cell markers in rat whisker hair follicles[J]. J Mol Histol, 2015, 46(3): 233-240.
35
李云矗,徐刚,徐成福. Wnt/β-catenin信号通路及其对骨髓间充质干细胞多向分化调节研究进展[J]. 牡丹江医学院学报, 2016, 37(1): 99-102.
36
Rao TP, Kühl M. An updated overview on Wnt signaling pathways:a prelude for more[J]. Circ Res, 2010, 106(12):1798-1806.
37
Hino M, Kamo M, Saito D, et al. Transforming growth factor-β1 induces invasion ability of HSC-4 human oral squamous cell carcinoma cells through the Slug/Wnt-5b/MMP-10 signalling axis[J]. J Biochem, 2016, 159(6):631-640.
38
Yoshida Y, Shimomura T, Sakabe T, et al. A role of Wnt/beta-catenin signals in hepatic fate specification of human umbilical cord blood-derived mesenchymal stem cells[J]. Am J Physiol Gastrointest Liver Physiol, 2007, 293(5):G1089-1098.
39
Ke Z, Zhou F, Wang L, et al. Down-regulation of Wnt signaling could promote bone marrow-derived mesenchymal stem cells to differentiate into hepatocytes[J]. Biochem Biophys Res Commun, 2008, 367(2): 342-348.
40
吴志方,罗辉,罗毅文. 骨髓间充质干细胞迁移的信号通路的研究进展[J]. 医学综述, 2016, 22(22):4377-4380.
41
Lai SY, Johnson FM. Defining the role of the JAK-STAT pathway in head and neck and thoracic malignancies: implications for future therapeutic approaches[J]. Drug Resist Updat, 2010, 13(3):67-78.
42
He G, Karin M. NF-κB and STAT3-key players in liver inflammation and cancer[J]. Cell Res, 2011, 21(1):159-168.
43
Geletu M, Guy S, Raptis L. Effects of SRC and STAT3 upon gap junctional, intercellular communication in lung cancer lines[J]. Anticancer Res, 2013, 33(10):4401-4410.
44
Ramakrishna G, Rastogi A, Trehanpati N, et al. From cirrhosis to hepatocellular carcinoma: new molecular insights on inflammation and cellular senescence[J]. Liver Cancer, 2013, 2(3-4):367-383.
45
Ishida F, Matsuda K, Sekiguchi N, et al. STAT3 gene mutations and their association with pure red cell aplasia in large granular lymphocyte leukemia[J]. Cancer Sci, 2014, 105(3):342-346.
46
Siveen KS, Sikka S, Surana R, et al. Targeting the STAT3 signaling pathway in cancer: role of synthetic and natural inhibitors[J]. Biochim Biophys Acta, 2014, 1845(2):136-154.
47
Stepkowski SM, Chen WH, Ross JA, et al. STAT3: an important regulator of multiple cytokine functions[J]. Transplantation, 2008, 85(10):1372-1377.
48
Lam SP, Luk JM, Man K, et al. Activation of interleukin-6-induced glycoprotein 130/signal transducer and activator of transcription 3 pathway in mesenchymal stem cells enhances hepatic differentiation, proliferation, and liver regeneration[J]. Liver Transpl, 2010, 16(10): 1195-1206.
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