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中华细胞与干细胞杂志(电子版) ›› 2017, Vol. 07 ›› Issue (06) : 369 -373. doi: 10.3877/cma.j.issn.2095-1221.2017.06.011

所属专题: 文献

综述

干细胞对皮肤瘢痕的治疗作用
张文博1, 孙善全2,()   
  1. 1. 400016 重庆,重庆医科大学2014级临床医学一系乙(四)班
    2. 400016 重庆,重庆医科大学解剖学教研室
  • 收稿日期:2017-08-18 出版日期:2017-12-01
  • 通信作者: 孙善全
  • 基金资助:
    重庆医科大学大学生科学研究与创新实验项目(2016-18)

Effectiveness stem cells in treating scar of skin

Wenbo Zhang1, Shanquan Sun2,()   

  1. 1. Class B(4) of grade 2014, Department (1) of Clinical Medicine, Chongqing Medical University, Chongqing 400016, China
    2. Department of Anatomy, Chongqing Medical University, Chongqing 400016, China
  • Received:2017-08-18 Published:2017-12-01
  • Corresponding author: Shanquan Sun
  • About author:
    Corresponding author: Sun Shanquan, Email:
引用本文:

张文博, 孙善全. 干细胞对皮肤瘢痕的治疗作用[J]. 中华细胞与干细胞杂志(电子版), 2017, 07(06): 369-373.

Wenbo Zhang, Shanquan Sun. Effectiveness stem cells in treating scar of skin[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2017, 07(06): 369-373.

皮肤瘢痕的治疗是临床难题,近年开展的干细胞移植为皮肤瘢痕的治疗开辟了一种新的治疗方法。为评估干细胞对皮肤瘢痕的治疗作用,探索皮肤疤痕的有效治疗方法,本文对干细胞对皮肤瘢痕的治疗作用进行了综述。已报道的临床多种干细胞治疗皮肤疤痕,均取得了较为肯定的治疗效果,但从整体水平观察,还处于初步探索阶段,积极开展不同种类干细胞对不同种类皮肤瘢痕类型的治疗效果,给药途径、干细胞浓度、剂量和安全性等多中心系统的规范研究,及治疗机制的深入探讨,将有力促进干细胞治疗皮肤瘢痕的广泛临床应用。

Scar of skin is hard to be treated clinically. The transplantation of stem cells has provided a new method for the treatment of the disease in recent years. In order to evaluate the therapeutic effect of stem cells on skin scar and find the effective methods of treatment for the disease, we reviewed recent studies on the effectiveness of using stem cells to treat skin scar. Many studies have been reported that several types of stem cells were used to treat skin scar clinically and all the curative effects were satisfactory. However, many obstacles remain to be overcome in stem cells-skin scar clinically. These obstacles include as following: the type-selectively effectiveness of stem cells to skin scar; the criterions of administration route, concentration, dose and safety; the insight and mechanism into the action. It is believed that the viable solutions of the above obstacles will have a significant impact on the way to the clinical application of stem cells-skin scar treatment.

图1 胸廓瘢痕羊膜细胞治疗前后对比
图2 接受自体ADIPOCELL治疗的3例患者
1
Utsunomiya T, Shimada M, Imura S, et al. Human Adipose-Derived stem cells: potential clinical applications in surgery[J].Surg Today, 2011, 41(1):18-23.
2
Akita S, Yoshimoto H, Akino K, et al. Early experiences with stem cells in treating chronic wounds[J]. Clin Plast Surg, 2012, 39(3):281-292.
3
Zhang J, Li Y, Bai X, et al. Recent advances in hypertrophic scar[J].Histol Histopathol, 2017:11908.
4
Li Q, Zhang C, Fu X. Will stem cells bring hope to pathological skin scar treatment?[J].Cytotherapy, 2016, 18(8):943-956.
5
江兰,刘世宇,李海建,等.人羊膜上皮干细胞对皮肤增生性瘢痕形成的作用[J].中国皮肤性病学杂志, 2011, 25(10):747-750, 782.
6
邱林,金先庆,Paul A Kingston,等.基因修饰bmscs抑制增生性瘢痕的实验研究[J].中国修复重建外科杂志, 2008, 22(2):212-216.
7
武艳,杨岚,陈志会,等.骨髓间充质干细胞抑制皮肤瘢痕形成的机制研究[J].医学研究杂志, 2016, 45(5):81-85.
8
陈璐,王达利,魏在荣,等.自体脂肪源性间充质干细胞局部移植对兔耳增生性瘢痕形成的影响[J].中华烧伤杂志, 2016, 32(10):582-587.
9
张琪,刘李娜,邓景成,等.瘢痕内注射脂肪来源干细胞对兔耳增生性瘢痕的抑制作用研究[J].组织工程与重建外科杂志, 2015, 11(3):139-143.
10
卞媛媛,梁久龙,韩悦,等.兔自体脂肪来源干细胞对增生性瘢痕的作用研究[J].实用皮肤病学杂志, 2013, 6(1):3-6.
11
Yun IS, Jeon YR, Lee WJ, et al. Effect of human adipose derived stem cells on scar formation and remodeling in a pig model: a pilot study[J]. Dermatol Surg, 2012, 38(10):1678-1688.
12
Fang F, Huang RL, Zheng Y, et al. Bone marrow derived mesenchymal stem cells inhibit the proliferative and profibrotic phenotype of hypertrophic scar fibroblasts and keloid fibroblasts through paracrine signaling[J].J Dermatol Sci, 2016, 83(2):95-105.
13
武艳,袁晓环,杨岚,等.间充质干细胞条件培养液对正常成纤维细胞及瘢痕成纤维细胞转化生长因子β产生和信号通路的影响[J].中国组织工程研究, 2016, 20(29):4349-4354.
14
张文夺,邓呈亮,郭常敏,等.人真皮间充质干细胞对增生性瘢痕成纤维细胞α-SMA和DCN表达的影响[J].中华整形外科杂志, 2016, 32(4):285-292.
15
Hemphill C, Stavoe K, Khalpey Z. First in man: amniotic stem cell injection Promotes scar remodeling and healing processes in late-stage fibrosis[J]. Int J Cardiol, 2014, 174(2):442-443.
16
Ibrahim ZA, Eltatawy RA, Ghaly NR, et al. Autologus bone marrow stem cells in atrophic acne scars:A pilot study[J]. J Dermatolog Treat, 2015, 26(3):260-265.
17
Kim M, Kim I, Lee SK, et al. Clinical trial of autologous differentiated adipocytes from stem cells derived from human adipose tissue[J]. Dermatol Surg, 2011, 37(6):750-759.
18
Zhou BR, Zhang T, Bin Jameel AA, et al. The efficacy of conditioned media of adipose-derived stem cells combined with ablative Carbon dioxide fractional resurfacing for atrophic acne scars and skin rejuvenation[J]. J Cosmet Laser Ther, 2016, 18(3):138-148.
19
Klinger M, Marazzi M, Vigo D, et al. Fat injection for cases of severe burn outcomes: A new perspective of scar remodeling and reduction[J]. Aesthetic Plast Surg, 2008, 32(3):465-469.
20
Klinger M, Caviggioli F, Klinger FM, et al. Autologous fat graft in scar treatment[J]. J Craniofac Surg, 2013, 24(5):1610-1615.
21
Pallua N, Baroncini A, Alharbi Z, et al. Improvement of facial scar appearance and microcirculation by autologous lipofilling[J]. J Plast Reconstr Aesthet Surg, 2014, 67(8):1033-1037.
22
Ciancio F, Parisi D, Innocenti A, et al. Effectiveness of autologous fat grafting in adherent scars: results obtained by a comprehensive scar evaluation protocol[J].Plast Reconstr Surg, 2017,140(2):355e-356e.
23
Jaspers MEH, Middelkoop E, van Zuijlen PPM. Reply:effectiveness of autologous fat grafting in adherent scars: results obtained by a comprehensive scar evaluation protocol[J]. Plast Reconstr Surg, 2017, 139(5):1217e-1218e.
24
Negenborn VL, Groen JW, Smit JM, et al. Reply:the use of autologous fat grafting for treatment of scar tissue and scar-related conditions:a systematic review[J]. Plast Reconstr Surg, 2016, 138(3):552e-553e.
25
Azzam OA, Atta AT, Sobhi RM, et al. Fractional CO(2)laser treatment vs autologous fat transfer in the treatment of acne scars:a comparative study[J].J Drugs Dermatol, 2013, 12(1):e7-e13.
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