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中华细胞与干细胞杂志(电子版) ›› 2017, Vol. 07 ›› Issue (06) : 364 -368. doi: 10.3877/cma.j.issn.2095-1221.2017.06.010

所属专题: 文献

综述

毛囊干细胞在皮肤创伤修复中的促进作用
裴卓1, 周聪1, 张一鸣2, 李玉红3,()   
  1. 1. 400038 重庆,陆军军医大学学员旅
    2. 400038 重庆,陆军军医大学新桥医院整形美容科
    3. 400038 重庆,陆军军医大学基础部细胞生物学教研室
  • 收稿日期:2017-03-27 出版日期:2017-12-01
  • 通信作者: 李玉红
  • 基金资助:
    国家自然科学基金(81472895,81471876)

Promoting effect of hair follicle stem cells in the wound healing of skin

Zhuo Pei1, Cong Zhou1, Yiming Zhang2, Yuhong Li3,()   

  1. 1. Cadet Brigade, Army Medical University, Chongqing 400038, China
    2. Department of Plastic and Cosmetic Surgery, Xinqiao Hospital, Army Medical University, Chongqing 400038, China
    3. Department of Cell Biology, Army Medical University, Chongqing 400038, China
  • Received:2017-03-27 Published:2017-12-01
  • Corresponding author: Yuhong Li
  • About author:
    Corresponding author:Li Yuhong, Email:
引用本文:

裴卓, 周聪, 张一鸣, 李玉红. 毛囊干细胞在皮肤创伤修复中的促进作用[J]. 中华细胞与干细胞杂志(电子版), 2017, 07(06): 364-368.

Zhuo Pei, Cong Zhou, Yiming Zhang, Yuhong Li. Promoting effect of hair follicle stem cells in the wound healing of skin[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2017, 07(06): 364-368.

毛囊干细胞介导毛囊再生,近年研究发现毛囊干细胞在皮肤创伤修复中也发挥重要作用。文章通过对以毛囊干细胞为基础所进行的各种实验总结,揭示了毛囊干细胞可以促进毛囊再生,参与血管形成,皮肤浅表神经修复再生,皮肤附属器官重建以及皮肤表皮重建等过程,阐明了毛囊干细胞在皮肤损伤修复过程中的重要作用,同时阐明目前毛囊干细胞对皮肤创伤修复这一方向所面临的局限以及未来的发展前景。

Hair follicle stem cells function in hair follicle regeneration. Recent researches reveal that hair follicle stem cells also function in wound healing of skin. Various experiments of the hair follicle stem cells reveals that hair follicle stem cells may participate in the regeneration of hair follicle regeneration, the formation of blood vessels, skin superficial nerve repair and regeneration, skin appendages reconstruction and epidermis reconstruction process. The results prove that the hair follicle stem cells play an important role in the repair of skin injury and clarify the limitations and future prospects of hair follicle stem cells in skin wound repair.

1
Yu H, Kumar SM, Kossenkov AV, et al. Stem cells with neural crest characteristics derived from the Bulge region of cultured human hair follicles[J].J Invest Dermatol, 2010, 130(5):1227-1236.
2
El Seady R, Huisman MA, Löwik CW, et al. Uncomplicated differentiation of stem cells into bipolar neurons and myelinating glia [J].Biochem Biophys Res Commun, 2008, 376(2):358-362.
3
方少霞,郭芬.损伤皮肤修复和伤口愈合过程中的干细胞:问题与前景[J].中国组织工程研究, 2016, 20(23):3491-3496.
4
杜伟斌,全仁夫,郑宣,等.毛囊干细胞在皮肤伤口修复中的促进作用[J].中国组织工程研究, 2015, 19(14):2278-2282.
5
王瑶.毛囊干细胞的多分化潜能及其向汗腺细胞分化的实验研究[D].天津:南开大学, 2013: 53-58.
6
陈瑞琦,廖联明.毛囊:微环境与干细胞相互作用的理想模型[J/CD].中华细胞与干细胞杂志(电子版), 2015, 5(3):61-64.
7
Zhang H, Zhao H, Qiao J, et al. Expansion of hair follicle stem cells sticking to isolated sebaceous glands to generatein vivoepidermal structures[J]. Cell Transplant, 2016, 25(11):2071-2082.
8
周洪军.构建组织工程化毛囊的初步研究[D].广州:南方医科大学, 2008.
9
Soteriou D, Kostic L, Sedov E, et al. Isolating hair follicle stem cells and epidermal keratinocytes from dorsal mouse skin[J]. J Vis Exp, 2016 (110):1-6.
10
王媛,魏红.毛囊干细胞在毛发生长发育中的作用[J].中国科技信息, 2011, 7(7):220-222.
11
Sribenja S, Wongkham S, Wongkham C, et al. Roles and mechanisms ofβ-thymosins in cell migration and cancer metastasis:an update[J]. Cancer Invest, 2013, 31(2):103-110.
12
Hsu YC, Pasolli HA, Fuchs E. Dynamics between stem cells, niche, and progeny in the hair follicle[J]. Cell, 2011, 144(1):92-105.
13
Rompolas P, Mesa KR, Greco V. Spatial organization within a niche as a determinant of stem-cell fate[J]. Nature, 2013, 502(7472):513-518.
14
Qiu W, Lei M, Zhou L, et al. Hair follicle stem cell proliferation, Akt and Wnt signaling activation in TPA-induced hair regeneration[J].Histochem Cell Biol, 2017, 147(6):749-758.
15
谭挺,胡志奇.毛囊细胞移植法诱导毛囊的初步研究[J].南方医科大学学报, 2009, 29(10):1987-1989.
16
许志成,李宏,张群.毛囊干细胞体外诱导分化为血管内皮细胞的实验研究[J].组织工程与重建外科杂志, 2012, 8(5):241-244.
17
Wang TW, Sun JS, Wu HC, et al. Evaluation and biological characterization of bilayer gelatin/chondroitin-6-sulphate/hyaluronic acid membrane[J]. J Biomed Mater Res B Appl Biomater, 2007, 82(2):390-399.
18
Quan R, Zheng X, Xu S, et al. Gelatin-chondroitin-6-sulfate-hyaluronic acid scaffold seeded with vascular endothelial growth factor 165 modified hair follicle stem cells as a three-dimensional skin substitute[J]. Stem Cell Res Ther, 2014, 5(5):118.
19
杜伟斌,全仁夫,郑宣,等.毛囊干细胞体外诱导成血管内皮细胞的实验研究[J/CD].中华细胞与干细胞杂志(电子版), 2016, 6(5):284-291.
20
Quan R, Du W, Zheng X, et al. VEGF165 induces differentiation of hair follicle stem cells into endothelial cells and plays a role inin vivoangiogenesis [J]. J Cell Mol Med, 2017, 21(8):1593-1604.
21
许志成,李宏,张群.体外诱导毛囊干细胞成血管平滑肌细胞的实验研究[J].组织工程与重建外科, 2012, 8(4):181-184.
22
Liu JY, Peng HF, Andreadis ST. Contractile smooth muscle cells derived from hair-follicle stem cells[J]. Cardiovasc Res, 2008, 79(1):24-33.
23
Xu ZC, Zhang Q, Li H. Human hair follicle stem cell differentiation into contractile smooth muscle cells is induced by transforming growth factor-β1 and platelet-derived growth factor BB[J]. Mol Med Rep, 2013, 8(6):1715-1721.
24
Xu ZC, Zhang Q, Li H. Differentiation of human hair follicle stem cells into endothelial cells induced by vascular endothelial and basic fibroblast growth factors[J]. Mol Med Rep, 2014, 9(1):204-210.
25
Rodero MP, Khosrotehrani K. Skin wound healing modulation by macrophages[J]. Int J Clin Exp Pathol, 2010, 3(7):643-653.
26
董智勇.以毛囊干细胞作为种子细胞构建组织工程表皮的研究[D].长春:吉林大学, 2010 .
27
林森,周红利,聂政.毛囊干细胞合成β-NGF及其受体p75NTR对皮肤创伤的早期修复作用[J].成都医学院学报, 2010, 5(4):301-305.
28
Blazejewska EA, Schlötzer-Schrehardt U, Zenkel M, et al. Corneal limbal microenvironment can induce transdifferentiation of hair follicle stem cells into corneal epithelial-like cells[J]. Stem Cells, 2009, 27(3):642-652.
29
Wang Y, Liu ZY, Zhao Q, et al. Future application of hair follicle stem cells: capable in differentiation into sweat gland cells[J]. Chin Med J (Engl), 2013, 126(18):3545-3552.
30
Panteleyev AA, Rosenbach T, Paus R, et al. The Bulge is the source of cellular renewal in the sebaceous gland of mouse skin[J]. Arch Dermatol Res, 2000, 292(11):573-576.
31
Sieber-Blum M, Grim M, Hu YF, et al. Pluripotent neural crest stem cells in the adult hair follicle[J]. Dev Dyn, 2004, 231(2):258-269.
32
Amoh Y, Li L, Campillo R, et al. Implanted hair follicle stem cells form Schwann cells that support repair of severed peripheral nerves[J]. Proc Natl Acad Sci U S A, 2005, 102(49):17734-17738.
33
Amoh Y, Li L, Katsuoka K, et al. Multipotent nestin-positive, keratin-negative hair-follicle Bulge stem cells can form neurons[J].Proc Natl Acad Sci U S A, 2005, 102(15):5530-5534.
34
Ghoroghi FM, Hejazian LB, Esmaielzade B, et al. Evaluation of the effect of NT-3 and biodegradable Poly-L-lactic acid nanofiber scaffolds on differentiation of rat hair follicle stem cells into neural cellsin vitro[J].J Mol Neurosci, 2013, 51(2):318-327.
35
谭晓华.人多潜能毛囊干细胞的分离培养及其向神经元样细胞诱导分化的研究[D].长春:吉林大学, 2010 .
36
Najafzadeh N, Nobakht M, Pourheydar B, et al. Rat hair follicle stem cells differentiate and promote recovery following spinal cord injury[J]. Neural Regen Res, 2013, 8(36):3365-3372.
37
Esmaeilzade B, Nobakht M, Joghataei MT, et al. Delivery of epidermal neural crest stem cells (EPI-NCSC) to hippocamp in Alzheimer's disease rat model [J]. Iran Biomed J, 2012, 16(1):1-9.
38
Kumar A, Mohanty S, Nandy SB, et al. Hair & skin derived progenitor cells: In search of a candidate cell for regenerative medicine[J]. Indian J Med Res, 2016, 143(2):175-183.
39
Jahoda CA, Reynolds AJ. Hair follicle dermal sheath cells: unsung participants in wound healing [J]. Lancet, 2001, 358(9291):1445-1448.
40
Heidari F, Yari A, Rasoolijazi H, et al. Bulge hair follicle stem cells accelerate cutaneous wound healing in rats[J].Wounds, 2016, 28(4):132-141.
41
史明艳.山羊毛囊干细胞及组织工程皮肤构建研究[D].杨凌:西北农林科技大学, 2006 .
42
房瑞,许零,陈欣,等.组织工程皮肤支架材料和种子细胞的研究进展[J].中国组织工程研究与临床康复, 2009, 13(47):9329-9333.
43
Nakrieko KA, Rudkouskaya A, Irvine TS, et al. Targeted inactivation of integrin-linked kinase in hair follicle stem cells reveals an important modulatory role in skin repair after injury[J]. Mol Biol Cell, 2011, 22(14):2532-2540.
44
Sun P, Watanabe K, Fallahi M, et al. Pygo2 regulatesβ-catenin-induced activation of hair follicle stem/progenitor cells and skin hyperplasia[J]. Proc Natl Acad Sci U S A, 2014, 111(28):10215-10220.
45
Tausche AK, Skaria M, Böhlen L, et al. An autologous epidermal equivalent tissue-engineered from follicular outer root sheath keratinocytes is as effective as split-thickness skin autograft in recalcitrant vascular leg ulcers[J].Wound Repair Regen, 2003, 11(4):248-252.
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