Progress in mechanism and application of immortalization of neural stem cells

doi:10.3877/cma.j.issn.2095-1221.2025.04.009

Abstract

Abstract:

Neural stem cells (NSCs) play a crucial role in the development, regeneration and repair of the nervous system. In recent years, with the in-depth research on the characteristics of NSCs, the immortalization technology of NSCs has gradually become a research hotspot in the field of neurobiology. This technique is not only able to overcome the problem of limited division capacity of NSCs in vitro culture, but also offers the possibility of their widespread use in basic research and clinical applications. However, there are still many challenges and problems in the mechanism, technical methods and clinical application of immortalized NSCs. This article summarizes the latest research progress of neural stem cell immortalization, and discusses its application potential in the field of neurodegenerative diseases and brain injury repair, hoping to provide a new perspective for the future research direction of stem cells and further promote the clinical application of immortalization technology of NSCs.

Key words: Neural stem cells, Immortalization, Clinical application, Neurodegenerative disease, Stroke

Yifu Ma, Fangling Sun, Tingting Liu, Xin Tian, Wen Wang. Progress in mechanism and application of immortalization of neural stem cells[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2025, 15(04): 251-256.

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