The effects of fibrosis on tumor-infiltrating immune cells——the formation of &amp;quot;armored &amp;amp; cold tumors&amp;quot;

doi:10.3877/cma.j.issn.2095-1221.2024.05.001

Abstract

Abstract:

Solid tumors have the unique extracellular matrix that can largely regulate the malignant behavior of tumor cells， including immune escape. The majority of solid tumors can form tumor fibrosis， which is mainly conferred by collagen in the extracellular matrix. Collagen is one of the most abundant proteins in the human body and mainly produced by tumor-associated fibroblasts in tumor tissues， which plays a critical role in tumor immune escape by inhibiting a variety of tumorinfiltrating immune cells. Collagen can be used both as a biomarker for prognosis in cancer patients and as an effective target for cancer therapy. This review summarized the roles of tumor fibrosis in tumors， especially the effect on tumor-infiltrating immune cells， and focused on the research methods of tumor fibrosis and treatment-related research progress. In addition， this review introduces the interpretation of "immuno-collagenic subtypes" based on collagen deposition and immune activity and the concept of "armored & cold tumors" proposed by our research group.

Key words: Fibrosis, Collagen, Tumor-infiltrating immune cells, Armored &amp, cold tumor

Jie Mei, Rui Xu, Yun Cai, Yichao Zhu. The effects of fibrosis on tumor-infiltrating immune cells——the formation of "armored & cold tumors"[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2024, 14(05): 257-263.

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References 64

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