Advances of amniotic membrane and its derived epithelial stem cells in corneal regenerative medicine

doi:10.3877/cma.j.issn.2095-1221.2023.05.006

Abstract

Abstract:

Corneal injury is an important category of blinding eye diseases, which seriously impairs patients' visual effect and life quality. Located in the innermost layer of the placenta, the amniotic membrane is a notable source of perinatal stem cells. Amniotic epithelial stem cells (AESCs) possess the characteristics of pluripotency, low immunogenicity, immune regulation, and secretion of multiple growth factors. In preclinical studies, amniotic membrane transplantation can be performed directly, or it can be used as a stem cell carrier, or amniotic membrane extract can be used to promote corneal repair. In addition, transplantation of AESCs after differentiation, culture supernatant and exosomes of AESCs also showed good effects on corneal injury repair. In clinical practice, the amniotic membrane is administrated through direct transplantation or transplantation with stem cells. This article reviews the characteristics of the amniotic membrane and AESCs and their application in corneal regenerative medicine to lay a foundation for future research.

Key words: Amniotic membrane, Epithelial stem cells, Cornea, Regenerative medicine

Jianan Huang, Tuoying Jiang, Ke Yao, Luyang Yu, Jinying Li. Advances of amniotic membrane and its derived epithelial stem cells in corneal regenerative medicine[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2023, 13(05): 299-303.

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URL: https://zhxbygxbzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2095-1221.2023.05.006

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References 58

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