Effects of gender differences on biological characteristics of mesenchymal stem cells

doi:10.3877/cma.j.issn.2095-1221.2021.05.010

Abstract

Abstract:

Mesenchymal stem cells (MSCs) is a hot topic in regenerative medicine and clinical treatment field due to their regeneration properties and immunomodulatory functions. MSCs have different biological characteristics by different tissues and gender sources. We summarized and discussed the differences in MSCs biological characteristics from different gender sources, such as surface antigens, proliferation, differentiation, immunosuppression and immune regulation function, and the significant differences showed in MSCs treatments from different gender in recent studies. Furthermore, we summarized the intrinsic factors caused by the MSCs functions, and the correlation in gene expression level from different genders of MSCs. And all of above information may support in the MSCs clinical application.

Key words: Mesenchymal stem cells, Gender differences, Cell function, Transplantation, Cell therapy

Xuyan Sun, Xuejuan Zhang, Jiangning Zhao, Yuxia Wang, Zongsheng Gao, Xiaobo Li. Effects of gender differences on biological characteristics of mesenchymal stem cells[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2021, 11(05): 317-320.

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References 28

1	Anna A, Barbara L, Miroslaw J. Concise review: mesenchymal stem cells: from roots to boost[J]. Stem Cells, 2019, 37(7):855-864.
2	Bridget MD, Aiping Lu, Jessica C, et al. A role for cell sex in stem cell-mediated skeletal muscle regeneration: female cells have higher muscle regeneration efficiency[J]. J Cell Biol, 2007, 177(1):73-86.
3	Laurenti E, Göttgens B. From haematopoietic stem cells to complex differentiation landscapes[J]. Nature, 2018, 553(7689):418-426.
4	Caroline L, Mélanie G, Hélène A, et al. Mesenchymal stem/stromal cell production compliant with good manufacturing practice: comparison between bone marrow, the gold standard adult source, and Wharton's Jelly, an extraembryonic source[J]. J Clin Med, 2019, 8(12):2207.
5	Ma YY, Ma J, Zhao YY, et al. Comparison of phenotypic markers and neural differentiation potential of human bone marrow stromal cells from the cranial bone and iliac crest[J]. J Cell Physiol, 2019, 234(9):15235-15242.
6	Di Trapani M, Bassi G, Ricciardi M, et al. Comparative study of immune regulatory properties of stem cells derived from different tissues[J]. Stem Cells Dev, 2013, 22(22):2990-3002.
7	Zhang YY, Lv PJ, Li YL, et al. Comparison of the biological characteristics of umbilical cord mesenchymal stem cells derived from the human heterosexual twins[J]. Differentiation, 2020, 114:1-12.
8	Siegel G, Kluba T, Hermanutz KU, et al. Phenotype, donor age and gender affect function of human bone marrow-derived mesenchymal stromal cells[J]. BMC Med, 2013, 11:146.
9	Bourin P, Bunnell BA, Casteilla L, et al. Stromal cells from the adipose tissue-derived stromal vascular fraction and culture expanded adipose tissue-derived stromal/stem cells: a joint statement of the International Federation for Adipose Therapeutics and Science (IFATS) and the International Society for Cellular Therapy (ISCT)[J]. Cytotherapy, 2013, 15(6):641-648.
10	Joerger MMS, Marx C, Oppliger B, et al. Mesenchymal stem cells from Wharton's Jelly and amniotic fluid[J]. Best Pract Res Clin Obstet Gynaecol, 2016, 31:30-44.
11	Rossetti R, Rós FA, Souza LEB, et al. Hypoxia-cultured mouse mesenchymal stromal cells from bone marrow and compact bone display different phenotypic traits[J]. Exp Cell Res, 2021, 399(1):112434.
12	Singh SP, Tripathy NK, Nityanand S. Comparison of phenotypic markers and neural differentiation potential of multipotent adult progenitor cells and mesenchymal stem cells[J]. World J Stem Cells, 2013, 5(2):53-60.
13	Ardakani AHG, Khan WS. The influence of ageing and gender in musculoskeletal stem cell[J]. Curr Stem Cell Res Ther, 2018, 13(6):432-437.
14	Li XY, Bai J, Ji X, et al. Comprehensive characterization of four different populations of human mesenchymal stem cells as regards their immune properties, proliferation and differentiation[J]. Int J Mol Med, 2014, 34(3):695-704.
15	Deasy BM, Lu A, Tebbets JC, et al. A role for cell sex in stem cell-mediated skeletal muscle regeneration: female cells have higher muscle regeneration efficiency[J]. J Cell Biol, 2007, 177(1):73-86.
16	von Roth P, Duda GN, Radojewski P, et al. Mesenchymal stem cell therapy following muscle trauma leads to improved muscular regeneration in both male and female rats[J]. Gend Med, 2012, 9(2):129-136.
17	Fossett E, Khan WS, Longo UG, et al. Effect of age and gender on cell proliferation and cell surface characterization of synovial fat pad derived mesenchymal stem cells[J]. J Orthop Res, 2012, 30(7):1013-1018.
18	Hong L, Sultana H, Paulius K, et al. Steroid regulation of proliferation and osteogenic differentiation of bone marrow stromal cells: a gender difference[J]. J Steroid Biochem Mol Biol, 2009, 114(3-5):180-185.
19	Pottmeier P, Doszyn O, Peuckert C, et al. Increased expression of Y-Encoded demethylases during differentiation of human male neural stem cells[J]. Stem Cells Dev, 2020, 29(23):1497-1509.
20	Lauren NR, Bao XP, Michael O, et al. Sex-dependent VEGF expression underlies variations in human pluripotent stem cell to endothelial progenitor differentiation[J]. Sci Rep, 2019, 9(1):16696.
21	Nathan K, Laura LY, Lin T, et al. Precise immunomodulation of the M1 to M2 macrophage transition enhances mesenchymal stem cell osteogenesis and differs by sex[J]. Bone Joint Res, 2019, 8(10):481-488.
22	Hass R, Kasper C, Böhm S, et al. Different populations and sources of human mesenchymal stem cells (MSC): a comparison of adult and neonatal tissue-derived MSC[J]. Cell Commun Signal, 2011, 9:12.
23	Von RP, Duda GN, Radojewski P, et al. Mesenchymal stem cell therapy following muscle trauma leads to improved muscular regeneration in both male and female rats[J]. Gend Med, 2012, 9(2):129-136.
24	Yuan J, Yu JX. Gender difference in the neuroprotective effect of rat bone marrow mesenchymal cells against hypoxiainduced apoptosis of retinal ganglion cells[J]. Neural Regen Res, 2016, 11(5):846-853.
25	Rinki R, Nathan M, Novotny PR, et al. Sex steroids and stem cell function[J]. Mol Med, 2008, 14(7-8):493-501.
26	Balzano F, Bellu E, Basoli V, et al. Lessons from human umbilical cord: gender differences in stem cells from Wharton's jelly[J]. Eur J Obstet Gynecol Reprod Biol, 2019, 234:143-148.
27	Patel S, Bonora G, Sahakyan A, et al. Human embryonic stem cells do not change their X inactivation status during differentiation[J]. Cell Reports, 2017, 18(1):54-67.
28	Chen S, Zhang W, Wang JM, et al. Differentiation of isolated human umbilical cord mesenchymal stem cells into neural stem cells[J]. Int J Ophthalmol, 2016, 9(1):41-47.

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