The role and mechanisms of long non-coding RNA in liver cancer cells

doi:10.3877/cma.j.issn.2095-1221.2020.02.007

Abstract

Abstract:

Hepatocellular carcinoma (HCC) is the most common pathological type in liver cancer, with a high mortality rate. Lack of a comprehensive understanding of the mechanisms underlying HCC development lead to poor prognosis. Long-chain non-coding RNA (LncRNA) is an important component in gene regulation, and can regulate the occurrence and development of liver cancer cells through epigenetic, transcriptional and post-transcriptional regulation. In recent years, with the in-depth study of the role of LncRNA in the development of HCC, new methods have been provided for the early diagnosis, disease control and prognosis assessment of HCC. This article reviews the research progress of the role of LncRNA in HCC.

Key words: Long noncoding RNA, Hepatocellular carcinoma, Review

Ni Zheng, Wei Xia. The role and mechanisms of long non-coding RNA in liver cancer cells[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2020, 10(02): 110-114.

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References 56

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LncRNA	表达变化	癌/抑癌基因	功能	参考文献
LncRNA-H19	上调	癌基因	可促进肿瘤细胞的迁移、侵袭	[9,10]
Lnc CRYBG3	上调	癌基因	有助于促进肝癌的发生和发展	[11]
LncRNA Ftx	上调	癌基因	通过促进葡萄糖代谢来促进肝癌细胞增殖与生长	[12]
HCG18	上调	癌基因	有助于促进肝癌的发生和发展	[13]
HOXA11-AS	上调	癌基因	有助于促进肝癌的发生和发展	[14]
HOST2	上调	癌基因	促进肝癌细胞增殖	[15]
Lnc-EGFR	下调	抑癌基因	抑制人肝癌细胞增殖和侵袭	[16]
LncRNA-H19	下调	抑癌基因	抑制人肝癌细胞增殖和侵袭，抑制效果呈时间依赖性	[9]
LncFOXO1	下调	抑癌基因	抑制人肝癌细胞增殖和侵袭	[17]
LncEHHADH-AS1	下调	抑癌基因	抑制肿瘤细胞增殖	[18]
LncRNA-GAS5	下调	抑癌基因	可诱导癌细胞凋亡	[19,20]
LncRNA-MEG3	下调	抑癌基因	抑制肝癌细胞增殖，同时也能够抑制自噬	[21]

LncRNA	表达变化	癌/抑癌基因	功能	参考文献
LncRNA-H19	上调	癌基因	可促进肿瘤细胞的迁移、侵袭	[9,10]
Lnc CRYBG3	上调	癌基因	有助于促进肝癌的发生和发展	[11]
LncRNA Ftx	上调	癌基因	通过促进葡萄糖代谢来促进肝癌细胞增殖与生长	[12]
HCG18	上调	癌基因	有助于促进肝癌的发生和发展	[13]
HOXA11-AS	上调	癌基因	有助于促进肝癌的发生和发展	[14]
HOST2	上调	癌基因	促进肝癌细胞增殖	[15]
Lnc-EGFR	下调	抑癌基因	抑制人肝癌细胞增殖和侵袭	[16]
LncRNA-H19	下调	抑癌基因	抑制人肝癌细胞增殖和侵袭，抑制效果呈时间依赖性	[9]
LncFOXO1	下调	抑癌基因	抑制人肝癌细胞增殖和侵袭	[17]
LncEHHADH-AS1	下调	抑癌基因	抑制肿瘤细胞增殖	[18]
LncRNA-GAS5	下调	抑癌基因	可诱导癌细胞凋亡	[19,20]
LncRNA-MEG3	下调	抑癌基因	抑制肝癌细胞增殖，同时也能够抑制自噬	[21]

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