Role of TWEAK/Fn14 signals in the regulation of proliferation and differentiation of stem cells

doi:10.3877/cma.j.issn.2095-1221.2020.01.011

Abstract

Abstract:

Tumor necrosisfactor (TNF) -like weak inducer of apoptosis (TWEAK) is a member of TNF superfamily, which plays an important role in the regulation of cell proliferation, differentiation and migration via its sole receptor, fibroblast growth factor inducible 14 (Fn14) . Recent studies have indicated that TWEAK/Fn14 signals act on a wide variety of stem cells such as hepatic stem cells, neural stem cells and mesenchymal stem cells, which intervene tissue repair and regeneration by affecting the proliferation and differentiation of stem cells. Here we review recent advances in studies, which would conduce to revealing the role of TWEAK/Fn14 signals in regulating stem cells' proliferation and differentiation as well as the mechanisms, and proposing new directions for stem cells in basic researches such as the pathogenesis of some diseases, and clinical researches such as cell therapies and tissue engineering.

Key words: TWEAK, Fn14, Signal pathway, Stem cell, Proliferation, Differentiation

Zhu Yan, Yumin Xia. Role of TWEAK/Fn14 signals in the regulation of proliferation and differentiation of stem cells[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2020, 10(01): 57-62.

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干细胞	涉及信号机制	生物学作用	参考文献
肝干细胞	NF-κB通路	促进增殖	[17,18,19]
神经干细胞	NF-κB通路	促进分化为神经元	[26]
成肌细胞	经典NF-κB途径	促进增殖、抑制分化	[34,35,36]
	非经典NF-κB途径	促进融合形成肌纤维	[34,37]
骨髓间充质干细胞	NF-κB通路	促进增殖	[40,41]
脂肪间充质干细胞	未知	抑制分化为脂肪细胞	[43]

干细胞	涉及信号机制	生物学作用	参考文献
肝干细胞	NF-κB通路	促进增殖	[17,18,19]
神经干细胞	NF-κB通路	促进分化为神经元	[26]
成肌细胞	经典NF-κB途径	促进增殖、抑制分化	[34,35,36]
	非经典NF-κB途径	促进融合形成肌纤维	[34,37]
骨髓间充质干细胞	NF-κB通路	促进增殖	[40,41]
脂肪间充质干细胞	未知	抑制分化为脂肪细胞	[43]

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