To investigate the effect of serum TGF-β, GFAP and expression of immune cells on the survival of patients with malignant glioma after simultaneous intensity modulated radiotherapy during the same period.

80 gradeⅢglioma patients who received postoperative simultaneous intensity modulated radiotherapy in Neurosurgery Department in the Affiliated Hospital of Inner Mongolia Medical University between February, 2015 and February, 2017 were retrospectively studied. There were 40 cases of complete removal of the lesion and 40 cases of partial resection. The levels of serum TGF-β, GFAP, IL-6, IL-8, IL-10 and TNF-αin the patients were measured before, after the operation and after simultaneous intensity modulated radiotherapy. The short-term effect and long-term effect of the two groups were compared according to the intracranial lesion changes by enhanced brain CT and 3-year follow-up results. The comparisons of TGF-β, GFAP, IL-6, IL-8, IL-10 and TNF-αlevels were completed byttest, and the comparisons among different periods were completed by analysis of variance.

The total short-term effective rate was 77.50﹪, and there was no significant difference between the complete resection (85﹪) and the partial resection (70﹪) patients (P> 0.05) . With the prolongation of time, the survival rate of the patients decreased gradually. The long-term survival rate of patients underwent radical resection and simultaneous intensity modulated radiotherapy was higher (P₂= 0.0441,P₃= 0.0322) . The more thoroughly resection was, the better short-term effect (u = 2.1993,P= 0.0279) and long-term effect (u =4.6247,P= 0.0042) were. TGF-β [ (51.47±10.88) ng/L, (33.16±13.08) ng/L, (21.92±8.79) ng/L,F= 6.3135,P= 0.0452], GFAP[ (83.59±81.35) ng/L, (57.61±82.33) ng/L, (21.05±35.69) ng/L,F= 8.0315,P= 0.0236], IL-6[ (14.37±4.62) ng/L, (14.05±4.51) ng/L, (12.11±3.42) ng/L,F= 9.9532, P = 0.0152], IL-8[ (44.51±4.97) ng/L, (30.53±4.60) ng/L,F= 5.9128,P= 0.0356], IL-10[ (142.32±26.36) ng/L, (70.02±27.80) ng/L,F= 6.7482,P= 0.0275]and TNF-α[ (43.30±4.01) ng/L, (32.16±3.07) ng/L, F= 6.2143,P= 0.0281]before, after operation and after simultaneous intensity modulated radiotherapy were decreased in partial resection patients. Serum TGF-β, GFAP, IL-6, IL-8, IL-10 and TNF-αlevels in complete resection patients after simultaneous intensity modulated radiotherapy were statistically different from partial resection patients (Pall < 0.05) . The more thoroughly the resection was, the more obvious the decrease was.

The levels of serum TGF-β, GFAP and immune cells in patients with malignant glioma after simultaneous intensity modulated radiotherapy were significantly lower than those in the control group, and the therapeutic effect and survival rate were better. The levels of serum TGF-β, GFAP and the expression of immune cells can effectively indicate the curative effect and prognosis of patients with malignant glioma after simultaneous intensity modulated radiotherapy.