The patients with diabetic foot were mostly associated with lower extremity ischemia. It is the most important reason leading to diabetic foot ulcer, which is hard to be cured so as to been amputated. Traditional therapies could not reduce its high level amputation rate, which has been the clinical problem worldwide. Therefore, it is of important social significance to further explore the pathogenesis of diabetic foot, lower extremity vascular disease characteristics and new remedies strategies, and to promote the application. Stem cells has been already widely used in many fields. The functions such as the secretion cytokines can promote the angiogenesis and make the remedies on diabetic foot possible. This paper summarizes the research progress on actuality of stem cell therapy on diabetic foot further.