Involvement of epithelial stem cells in malignant transformation and mechanisms

doi:10.3877/cma.j.issn.2095-1221.2017.02.009

Abstract

Abstract:

Epithelial stem cells, which have the ability of self-renewal and multiple differentiation, play a crucial role in maintaining epithelial tissue homeostasis. Recently, many studies have showed that epithelial stem cells may be the tumour-initiating cells. The transformation of epithelial stem cell is not only affected by the microenvironment, but also promoted by dysregulation of signal pathways and gene mutations. However, the mechanism how epithelial stem cells transform and become tumor cells remains unclear. Here we review the relationships between epithelial stem cells and cancer stem cells and the mechanism of transformation of epithelial stem cells.

Key words: Epithelial cells, Neoplastic stem cells, Mechanisms

Shihui Zhang, Qiong Hu, Fuan Xie, Xiaoqian Hong, Kuancan Liu. Involvement of epithelial stem cells in malignant transformation and mechanisms[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2017, 07(02): 112-116.

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References 63

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组织器官	上皮干细胞标志物	肿瘤干细胞标志物	文献来源
肠	Lgr5⁺/ EPHB2⁺/CD44s⁺/CD44v6⁺	CD133⁺/ACDH1⁺	[12,13]
乳腺	ALDH1/ Lin-CD29hiCD24⁺	CD44⁺/CD24^- /CD133⁺/ALDH1⁺	[2,14,15,16]
肺	Lgr6⁺	Lgr6⁺/ CD133⁺	[17,18]
前列腺	CD45^-/CD31^-/Ter119^-/Sca-1⁺/CD49f⁺	ALDH1A1/CD44⁺/α2β1hi/CD133⁺	[3,19,20]
胃	Lgr5⁺/Mist1⁺	CD133⁺/CD44⁺/Nanog⁺/PSCA⁺	[21,22,23,24]
皮肤	Lgr6⁺/Gli⁺/K15⁺/SOX9⁺/CD34⁺/Lgr5⁺	CD34⁺/Lgr5⁺/CD133⁺/Nestin⁺	[11,25,26,27,28]
食管	Lgr5⁺	Lgr5⁺/CD133⁺	[29,30]

组织器官	上皮干细胞标志物	肿瘤干细胞标志物	文献来源
肠	Lgr5⁺/ EPHB2⁺/CD44s⁺/CD44v6⁺	CD133⁺/ACDH1⁺	[12,13]
乳腺	ALDH1/ Lin-CD29hiCD24⁺	CD44⁺/CD24^- /CD133⁺/ALDH1⁺	[2,14,15,16]
肺	Lgr6⁺	Lgr6⁺/ CD133⁺	[17,18]
前列腺	CD45^-/CD31^-/Ter119^-/Sca-1⁺/CD49f⁺	ALDH1A1/CD44⁺/α2β1hi/CD133⁺	[3,19,20]
胃	Lgr5⁺/Mist1⁺	CD133⁺/CD44⁺/Nanog⁺/PSCA⁺	[21,22,23,24]
皮肤	Lgr6⁺/Gli⁺/K15⁺/SOX9⁺/CD34⁺/Lgr5⁺	CD34⁺/Lgr5⁺/CD133⁺/Nestin⁺	[11,25,26,27,28]
食管	Lgr5⁺	Lgr5⁺/CD133⁺	[29,30]

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