Induced pluripotent stem cells (iPSCs) , with their unlimited proliferative capacity and multi-lineage differentiation potential, hold great promise in vascular research. This study aimed to systematically analyze the global trends, research hotspots, and future directions of iPSC-related vascular research using bibliometric methods.

Publications on iPSCs and vascular research were retrieved from the Web of Science Core Collection. Bibliometric and visualization analyses were conducted using Bibliometrix, VOSviewer, and CiteSpace, focusing on annual publication trends, country and institutional collaboration networks, keyword clustering and burst detection, as well as co-citation analysis.

The number of publications on iPSCs in vascular research has steadily increased. The United States and China lead this field and have established extensive international collaboration networks. Research hotspots have shifted from basic differentiation mechanisms to vascular regeneration, disease modeling, and translational applications. Keyword burst analysis highlighted endothelial differentiation, vascular regenerative medicine, and personalized therapy as emerging focal points.

Research on iPSCs in the vascular field is rapidly expanding, characterized by strong international collaboration and interdisciplinary integration. Future studies should emphasize clinical translation by integrating multi-omics and intelligent analytical approaches, thereby advancing the application of iPSCs in vascular graft development and novel therapeutic strategies.