Progress of exosome contents as diagnostic markers for pancreatic cancer

doi:10.3877/cma.j.issn.2095-1221.2023.01.007

Abstract

Abstract:

Pancreatic cancer, a tumor with very high malignancy and extremely low survival, seriously threatens patients' health. The lack of sensitive, specific diagnostic markers and prognostic monitoring is one of the important factors affecting survival. As one of the important mediators of cell secretion, exosome contents are rich in composition and have apparent tissue specificity. Screening biomarker molecules expressed explicitly in exosome contents of pancreatic cancer patients and evaluating their diagnostic value in clinical cohorts, has broad application prospects for early diagnosis and prognosis assessment of pancreatic cancer patients. This article mainly reviews the research progress of exosome content types as diagnostic markers for pancreatic cancer in recent years.

Key words: Exosomes, Pancreatic cancer, Tumor markers, Diagnosis

Xinxiong Li, Zaizhong Zhang, Hu Zhao, Chunhong Xiao, Lie Wang. Progress of exosome contents as diagnostic markers for pancreatic cancer[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2023, 13(01): 53-57.

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References 59

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种类	诊断标志物	表达	对照类型	样本来源
蛋白质	ZIP4^[12]	上调	PDAC、BP、HC	血清
	ALIX^[13]	上调	胰腺癌、OPT、HC	血浆
	CD44v6/ C1QBP^[15]	上调	肝转移、未转移；肿瘤、癌旁	血清；组织
	MIF^[16]	上调	肝转移、HC	血浆
	CKAP4^[44]	上调	PDAC、结肠息肉	血浆
	EphA2^[45]	上调	胰腺癌、HC	血清
	CD63^[46]	上调	胰腺癌、HC；术前、术后	血清
	CD133^[47]	上调	胰腺癌、良性疾病腹水	腹水
miRNA	miR-19b^[23]	上调	胰腺癌、OPT、CP、HC	血清
	miR-27a^[20]	上调	胰腺癌、胰腺炎、HC	组织
	miR-30b-5p^[48]	上调	PDAC、HC	血浆
	miR-1226-3p^[49]	上调	PDAC、BP、HC	血清
	miR-10b 、miR-30c、miR-106b等^[22]	上调	PDAC、CP、HC	血浆
	miR-4525、miR-451a 、miR-21等^[50]	上调	门静脉、外周；肿瘤、癌旁	血浆；组织
lncRNA	HULC^[25]	上调	PDAC、IPMN、HC	血清
	UCA1^[51]	上调	胰腺癌、HC	血清
	CCAT1^[52]	上调	胰腺癌、HC	血清
	linc-ROR^[53]	上调	胰腺癌、HC	血清
	LINC01133^[54]	上调	肿瘤、癌旁	组织
	LINC00623^[55]	上调	PDAC、HC；肿瘤、癌旁	血清；组织
tsRNA	tRF-Pro-AGG-004、tRF-Leu-CAG-002^[34]	上调	胰腺癌、HC	血清
	tsRNA-ValTAC-41、tsRNA-MetCAT-37^[35]	上调	PDAC、HC；肿瘤、癌旁	血清；组织
脂质	PE^[40]	上调	外周、癌旁、HC	血清

种类	诊断标志物	表达	对照类型	样本来源
蛋白质	ZIP4^[12]	上调	PDAC、BP、HC	血清
	ALIX^[13]	上调	胰腺癌、OPT、HC	血浆
	CD44v6/ C1QBP^[15]	上调	肝转移、未转移；肿瘤、癌旁	血清；组织
	MIF^[16]	上调	肝转移、HC	血浆
	CKAP4^[44]	上调	PDAC、结肠息肉	血浆
	EphA2^[45]	上调	胰腺癌、HC	血清
	CD63^[46]	上调	胰腺癌、HC；术前、术后	血清
	CD133^[47]	上调	胰腺癌、良性疾病腹水	腹水
miRNA	miR-19b^[23]	上调	胰腺癌、OPT、CP、HC	血清
	miR-27a^[20]	上调	胰腺癌、胰腺炎、HC	组织
	miR-30b-5p^[48]	上调	PDAC、HC	血浆
	miR-1226-3p^[49]	上调	PDAC、BP、HC	血清
	miR-10b 、miR-30c、miR-106b等^[22]	上调	PDAC、CP、HC	血浆
	miR-4525、miR-451a 、miR-21等^[50]	上调	门静脉、外周；肿瘤、癌旁	血浆；组织
lncRNA	HULC^[25]	上调	PDAC、IPMN、HC	血清
	UCA1^[51]	上调	胰腺癌、HC	血清
	CCAT1^[52]	上调	胰腺癌、HC	血清
	linc-ROR^[53]	上调	胰腺癌、HC	血清
	LINC01133^[54]	上调	肿瘤、癌旁	组织
	LINC00623^[55]	上调	PDAC、HC；肿瘤、癌旁	血清；组织
tsRNA	tRF-Pro-AGG-004、tRF-Leu-CAG-002^[34]	上调	胰腺癌、HC	血清
	tsRNA-ValTAC-41、tsRNA-MetCAT-37^[35]	上调	PDAC、HC；肿瘤、癌旁	血清；组织
脂质	PE^[40]	上调	外周、癌旁、HC	血清

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