Research progress in the interaction between intestinal flora metabolites and mesenchymal stem cells

doi:10.3877/cma.j.issn.2095-1221.2022.06.007

Abstract

Abstract:

Due to the function of proliferation, differentiation and immune regulation, mesenchymal stem cells (MSCs) have broad application prospects and currently show promising results in treating various autoimmune diseases. Related research shows that the metabolites of intestinal flora affect the function of MSCs, and MSCs also regulate the production of intestinal flora metabolites. Based on previous studies, this article reviews the interaction between some common intestinal flora metabolites (short-chain fatty acids, trimethylamine oxide, bile acids, and tryptophan metabolites) and MSCs. In addition, some feasible strategies for targeted regulation of MSCs based on intestinal flora metabolites are discussed, which can provide new ideas for studying various diseases, including autoimmune diseases.

Key words: Intestinal flora, Tryptophan, Metabolites, Mesenchymal stem cells, Short-chain fatty acids, Trimethylamine oxide, Bile acids

Cong Peng, Xiaoying Luo, Yangqiu Bai, Xiaoke Jiang, Bingyong Zhang. Research progress in the interaction between intestinal flora metabolites and mesenchymal stem cells[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2022, 12(06): 367-371.

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