Research progress of intravenous infusion of mesenchymal stromal cells in the treatment of ischemic heart disease

doi:10.3877/cma.j.issn.2095-1221.2022.02.007

Abstract

Abstract:

Ischemic heart disease (IHD) is one of the dangerous and severe disease. Recently, mesenchymal stromal cells (MSCs) have been more popular in the treatment of IHD due to their cardioprotective effect and low immunogenicity. The routes of MSCs transplantation for IHD therapy include intramyocardial injection, coronary artery/vein injection, and intravenous injection. Intravenous delivery is the least invasive and can be done multiple times. However, the problem of low homing rate of targeted myocardium may lead to poor myocardial protection. How to improve the targeted cardiac homing of intravenously injected MSCs is the key problem to improve the cardioprotection of MSCs, and it becomes more popular at present. The paper summarizes the status quo of MSCs in IHD treatment, research progress of the myocardial homing of intravenous MSCs, and the clinical application of intravenously injected MSCs for IHD.

Key words: Ischemic heart disease, Mesenchymal stromal cells, Homing, Chemokine, Chemokine receptor

Tingting Qi, Xiaoming Xu, Yunlong Xia, Yongzhen Guo, Miaomiao Fan, Yuan He, Mai Chen, Ling Tao, Wenjun Yan, Yanhong Fan. Research progress of intravenous infusion of mesenchymal stromal cells in the treatment of ischemic heart disease[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2022, 12(02): 105-109.

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URL: https://zhxbygxbzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2095-1221.2022.02.007

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