Advances in the effects of poly (ADP-ribose) polymerases on adipocyte and energy metabolism

doi:10.3877/cma.j.issn.2095-1221.2022.02.006

Abstract

Abstract:

Poly (ADP-ribose) polymerase (PARPs) , a class of ADP-ribose transferases, play a role in post-translational modification of protein. PARPs process and transfer the ADP-ribose unit of nicotinamide adenine dinucleotide (NAD⁺) to the target protein (ADP-ribosylation) , which can process the ADP-ribose unit of nicotinamide adenine dinucleotide (NAD⁺) and then transferred them to the target protein. Previous studies have found that PARPs are mainly involved in the process of DNA repair. In recent years, it has been found that PARPs are involved in the regulation of chromatin structure, gene expression and RNA processing and other biological processes, and they can also regulate adipocyte differentiation, mitochondrial biosynthesis and glucose transport, thereby they play an important role in regulating obesity and energy metabolism. In this review, we focus on the metabolic properties of PARPs in adipocytes and energy metabolism, aiming to fully understand its important role and significance in adipocyte research. It may provide new ideas for the study of obesity and metabolic diseases.

Key words: Poly (ADP-ribose) polymerases, Adipocyte, Obesity, Energy metabolism

Xuhong Lu, Fan Hu, Ying Yang. Advances in the effects of poly (ADP-ribose) polymerases on adipocyte and energy metabolism[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2022, 12(02): 100-104.

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