Research progress of extracellular vesicles derived from mesenchymal stem cells in the treatment of traumatic brain injury

doi:10.3877/cma.j.issn.2095-1221.2021.04.009

Abstract

Abstract:

Traumatic brain injury (TBI) is one of the leading causes of death and disability. With the development of stem cell therapy and regenerative medicine, it is possible for mesenchymal stem cells (MSCs) transplantation to treat TBI and improve craniocerebral neurological dysfunction. Current studies have shown that one of the neuroprotective effects of MSCs is based on the secretion of a variety of bioactive substances, in which extracellular vesicles (EVs) play a certain therapeutic role. The mechanism of MSC-EVs may be related to neuroprotection, regulating immune response, promoting angiogenesis, increasing neurogenesis and protecting the blood-brain barrier. This article mainly introduces the research progress of MSC-EVs in the treatment of TBI.

Key words: Mesenchymal stem cells, Traumatic brain injury, Extracellular vesicles, Nerve repair

Zhihong Zhou, Lihui Peng. Research progress of extracellular vesicles derived from mesenchymal stem cells in the treatment of traumatic brain injury[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2021, 11(04): 251-255.

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References 41

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microRNA	分子机制	作用细胞	效应	引文
miR-124	抑制TLR4 / NF-κB通路和激活PI3K / AKT信号通路	小胶质细胞	促进M2细胞生成，抑制炎症反应	[15]
miR-212-5p	抑制Ptgs2表达	神经元细胞	保护神经细胞，改善神经功能	[16]
miR-17-92	下调PTEN表达并激活PI3K / Akt / mTOR信号通路	神经元细胞	促进神经发生、少突胶质生成和神经可塑性	[17]
miR-126	激活PI3K / Akt / eNOS途径	内皮细胞	促进血管生成和保护血脑屏障	[18]
miR-132-3p	激活PI3K/Akt/eNOS信号通路	内皮细胞	促进血管生成和保护血脑屏障	[19]
miR-532-5p	抑制Ang-1 / Tie-2信号通路	周细胞	促进血管生成和保护血脑屏障	[20]
miR-21	抑制STAT3和NF-κB表达	神经元细胞	抑制炎症反应，增强神经可塑性	[21]

microRNA	分子机制	作用细胞	效应	引文
miR-124	抑制TLR4 / NF-κB通路和激活PI3K / AKT信号通路	小胶质细胞	促进M2细胞生成，抑制炎症反应	[15]
miR-212-5p	抑制Ptgs2表达	神经元细胞	保护神经细胞，改善神经功能	[16]
miR-17-92	下调PTEN表达并激活PI3K / Akt / mTOR信号通路	神经元细胞	促进神经发生、少突胶质生成和神经可塑性	[17]
miR-126	激活PI3K / Akt / eNOS途径	内皮细胞	促进血管生成和保护血脑屏障	[18]
miR-132-3p	激活PI3K/Akt/eNOS信号通路	内皮细胞	促进血管生成和保护血脑屏障	[19]
miR-532-5p	抑制Ang-1 / Tie-2信号通路	周细胞	促进血管生成和保护血脑屏障	[20]
miR-21	抑制STAT3和NF-κB表达	神经元细胞	抑制炎症反应，增强神经可塑性	[21]

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