Mechanism and application prospect of exosomes derived from mesenchymal stem cells in the treatment of inflammatory bowel disease

doi:10.3877/cma.j.issn.2095-1221.2020.06.009

Abstract

Abstract:

Inflammatory bowel disease (IBD) is a non-specific intestinal disease with unknown causes. Its incidence is increasing in recent years, and its medications' efficacy is limited at present. Mesenchymal stem cells (MSCs) have immunomodulatory and anti-inflammatory effects, which is expected to become an emerging treatment for IBD. However, many studies suggest that MSCs may treat diseases through paracrine manner due to their limited homing ability. Exosomes secreted by MSCs (MSCs-Exo) have most of the functions of MSCs and no potential for malignant differentiation, and exist stably in vivo, which make them high in research value in the field of stem cell therapy. Nevertheless, the mechanism of MSCs-Exo in the treatment of IBD is still unclear. The paper reviews the mechanism and application prospect of MSCs-Exo in the treatment of IBD.

Key words: Mesenchymal stem cells, Exosomes, Inflammatory bowel disease, Treatment, Mechanism

Shaopeng Yang. Mechanism and application prospect of exosomes derived from mesenchymal stem cells in the treatment of inflammatory bowel disease[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2020, 10(06): 368-372.

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URL: https://zhxbygxbzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2095-1221.2020.06.009

https://zhxbygxbzz.cma-cmc.com.cn/EN/Y2020/V10/I06/368

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