Advances of mesenchymal stem cells and their exosomes in repairing ionizing radiation damage

doi:10.3877/cma.j.issn.2095-1221.2020.05.010

Abstract

Abstract:

Ionizing radiation is widely used in X-ray imaging, radiotherapy and nuclear power, which would cause serious damage to normal tissue. Although some drugs can be used for the treatment of the injury, the effect is not satisfactory. Mesenchymal stem cells (MSC) have the ability to migrate to position of disease to promote the repair of damaged tissues, and have great applicational prospects in the treatment of many different types of ionizing radiation injuries. Mesenchymal stem cell exosomes have similar functions to MSC, such as repairing tissue damage, suppressing inflammatory responses and regulating the immune system. Therefore, they can be used to treat ionizing radiation injury instead of MSC. In this paper, the latest research progress on the biological effects of ionizing radiation, the biological functions and the repair of ionizing radiation damage of MSC and exosomes are reviewed.

Key words: Ionizing radiation, Mesenchymal stem cells, Exosome

Yuanhang Cheng, Jin Chen, Weizhen Wu. Advances of mesenchymal stem cells and their exosomes in repairing ionizing radiation damage[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2020, 10(05): 310-313.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhxbygxbzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2095-1221.2020.05.010

https://zhxbygxbzz.cma-cmc.com.cn/EN/Y2020/V10/I05/310

References 49

1	Puckett Y, Nappe TM. Ionizing Radiation[M/OL]//StatPearls [Internet]. StatPearls Publishing, 2019. URL
2	Kharji SA, Connell T, Bernier M, et al. Ionizing radiation in interventional cardiology and electrophysiology[J]. Can J Cardiol, 2019, 35(4):535-538.
3	Wei X, Yang X, Han ZP, et al. Mesenchymal stem cells: a new trend for cell therapy[J]. ActaPharmacol Sin, 2013, 34(6):747-754.
4	Phinney DG, Pittenger MF. Concise review: MSC-derived exosomes for Cell-Free therapy[J]. Stem Cells, 2017, 35(4):851-858.
5	Christensen DM, Livingston GK, Sugarman SL, et al. Management of ionizing radiation injuries and illnesses, part 3: radiobiology and health effects of ionizing radiation[J]. J Am Osteopath Assoc, 2014, 114(7): 556-565.
6	Abou-Zeid SM, El-Bialy BE, El-Borai NB, et al. Radioprotective effect of Date syrup on radiation-induced damage in Rats[J]. Sci Rep, 2018, 8(1):1-10.
7	Pollycove M, Feinendegen LE. Radiation-induced versus endogenous DNA damage: possible effect of inducible protective responses in mitigating endogenous damage[J]. Hum ExpToxicol, 2003, 22(6):290-306.
8	Santivasi WL, Xia F. Ionizing radiation-induced DNA damage, response, and repair[J]. Antioxid Redox Signal, 2014, 21(2):251-259.
9	Mavragani IV, Nikitaki Z, Kalospyros SA, et al. Ionizing radiation and complex DNA damage: from prediction to detection challenges and biological significance[J]. Cancers (Basel), 2019, 11(11).pii: E1789.
10	Christensen DM, Iddins CJ, Sugarman SL. Ionizing radiation injuries and illnesses[J]. Emerg Med Clin North Am, 2014, 32(1):245-265.
11	Christensen DM, Iddins CJ, Parrillo SJ, et al. Management of ionizing radiation injuries and illnesses, part 4: acute radiation syndrome[J]. J Am Osteopath Assoc, 2014, 114(9):702-711.
12	Iddins CJ, Christensen DM, Parrillo SJ, et al. Management of ionizing radiation injuries and illnesses, part 5: local radiation injury[J]. J Am Osteopath Assoc, 2014, 114(11):840-848.
13	Brown C, Mckee C, Bakshi S, et al. Mesenchymal stem cells: Cell therapy and regeneration potential[J]. J Tissue EngRegen Med, 2019, 13(9):1738-1755.
14	Matsuse D, Kitada M, Kohama M, et al. Human umbilical Cord-Derived mesenchymal stromal cells differentiate into functional schwann cells that sustain peripheral nerve regeneration[J]. J Neuropathol Exp Neurol, 2010, 69(9):973-985.
15	Bari CD, Roelofs AJ. Stem cell-based therapeutic strategies for cartilage defects and osteoarthritis[J]. Curr Opin Pharmacol, 2018, 40:74-80.
16	Potz BA, Scrimgeour LA, Pavlov VI, et al. Extracellular vesicle injection improves myocardial function and increases angiogenesis in a swine model of chronic ischemia[J]. J Am Heart Assoc, 2018, 7(12).pii: e008344.
17	Harrell CR, Simovic Markovic B, Fellabaum C, et al. Therapeutic potential of mesenchymal stem cell-derived exosomes in the treatment of eye diseases[J]. Adv Exp Med Biol.2018, 1089:47-57.
18	Volkman R, Offen D. Concise review: mesenchymal stem cells in neurodegenerative diseases[J]. Stem Cells, 2017, 35(8):1867-1880.
19	Lai RC, Yeo R WY, Lim SK. Mesenchymal stem cell exosomes[J]. Semin Cell Dev Biol, 2015, 40:82-88.
20	Elahi FM, Farwell DG, Nolta JA, et al. Preclinical translation of exosomes derived from mesenchymal stem/stromal cells[J]. Stem Cells, 2020, 38(1):15-21.
21	Vizoso FJ, Eiro N, Cid S, et al. Mesenchymal stem cell secretome: toward Cell-Free therapeutic strategies in regenerative medicine[J]. Int J Mol Sci, 2017, 18(9). pii: E1852.
22	Nawaz M, Fatima F, Vallabhaneni KC, et al. Extracellular vesicles: Evolving factors in stem cell biology[J]. Stem Cells Int, 2016, 2016:63-79.
23	Lai RC, Tan SS, Teh BJ, et al. Proteolytic potential of the MSC exosome proteome: Implications for an exosome-mediated delivery of therapeutic proteasome[J]. Int J Proteomics, 2012, 2012:1-14.
24	Qiu G, Zheng G, Ge MH, et al. Mesenchymal stem cell-derived extracellular vesicles affect disease outcomes via transfer of microRNAs[J]. Stem Cell Res Ther, 2018, 9(1):320.
25	Chen TS, Lai RC, Lee MM, et al. Mesenchymal stem cell secretes microparticles enriched in pre-microRNAs[J]. Nucleic Acids Res, 2010, 38(1):215-224.
26	Ma S, Xie N, Li W, et al. Immunobiology of mesenchymal stem cells[J]. Cell Death Differ, 2014, 21(2):216-225.
27	Shi Y, Wang Y, Li Q, et al. Immunoregulatory mechanisms of mesenchymal stem and stromal cells in inflammatory diseases[J]. Nat Rev Nephrol, 2018, 14(8):493-507.
28	Zhang Y, Chen Z, Feng L, et al. Ionizing radiation-inducible microRNA-21 induces angiogenesis by directly targeting PTEN[J]. Asian Pacific J Cancer Prev, 2019, 20(5):1587-1593.
29	Baidoo KE, Yong K, Brechbiel MW. Molecular pathways: Targeted α-particle radiation therapy[J]. Clin Cancer Res, 2013, 19(3):530-537.
30	Marta GN, Garicochea B, Carvalho AL, et al. MicroRNAs, cancer and ionizing radiation: Where are we?[J]. Rev Assoc Med Bras (1992), 2015, 61(3):275-281.
31	Chang PY, Qu YQ, Wang J, et al. The potential of mesenchymal stem cells in the management of radiation enteropathy[J]. Cell Death Dis, 2015, 6(8):e1840.
32	Kudo K, Liu Y, Takahashi K, et al. Transplantation of mesenchymal stem cells to prevent radiation-induced intestinal injury in mice[J]. J Radiat Res, 2010, 51(1): 73-79.
33	Semont A, Mouiseddine M, Francois A, et al. Mesenchymal stem cells improve small intestinal integrity through regulation of endogenous epithelial cell homeostasis[J]. Cell Death Dis, 2010, 17(6): 952-961.
34	Gong W, Guo M, Han Z, et al. Mesenchymal stem cells stimulate intestinal stem cells to repair radiation-induced intestinal injury[J]. Cell Death Dis, 2016, 7(9):e2387.
35	Kim K, Lee J, Jang H, et al. Photobiomodulation enhances the angiogenic effect of mesenchymal stem cells to mitigate Radiation-Induced enteropathy[J]. Int J Mol Sci, 2019, 20(5):1131.
36	Lou G, Chen Z, Zheng M, et al. Mesenchymal stem cell-derived exosomes as a new therapeutic strategy for liver diseases[J]. Exp Mol Med, 2017, 49(6):e346.
37	Chen YX, Zeng ZC, Sun J, et al. Mesenchymal stem cell-conditioned medium prevents radiation-induced liver injury by inhibiting inflammation and protecting sinusoidal endothelial cells[J]. J Radiat Res, 2015, 56(4):700-708.
38	Radwan RR, Mohamed HA. Nigella sativa oil modulates the therapeutic efficacy of mesenchymal stem cells against liver injury in irradiated rats[J]. J Photochem Photobiol B, 2018, 178:447-456.
39	Francois S, Mouiseddine M, Allenet-Lepage B, et al. Human Mesenchymal Stem Cells Provide Protection against Radiation-Induced Liver Injury by Antioxidative Process, Vasculature Protection, Hepatocyte Differentiation, and Trophic Effects[J]. Biomed Res Int, 2013, 2013:1-14.
40	柳安雄，王伟，钟自彪, 等. 间充质干细胞免疫调节作用在终末期肝病治疗中的研究进展[J]. 中华移植杂志(电子版), 2020, 14(1):49-53.
41	Zheng K, Wu W, Yang S, et al. Bone marrow mesenchymal stem cell implantation for the treatment of radioactivity induced acute skin damage in rats[J]. Mol Med Rep, 2015, 12(5): 7065-7071.
42	Sun J, Zhang Y, Song X, et al. The healing effects of conditioned medium derived from mesenchymal stem cells on Radiation-Induced skin wounds in rats[J]. Cell Transplant, 2019, 28(1):105-115.
43	Kim A, Shim S, Min-Jung K, et al. Mesenchymal stem cell-mediated Notch2 activation overcomes radiation-induced injury of the hematopoietic system[J]. Sci Rep, 2018, 8(1):1-12.
44	Wen S, Dooner M, Cheng Y, et al. Mesenchymal stromal cell-derived extracellular vesicles rescue radiation damage to murine marrow hematopoietic cells[J]. Leukemia, 2016, 30(11):2221-2231.
45	Zanoni M, Cortesi M, Zamagni A, et al. The role of mesenchymal stem cells in radiation-induced lung fibrosis[J]. Int J Mol Sci, 2019, 20(16):3876.
46	Yao Y, Zheng Z, Song Q. Mesenchymal stem cells: A double-edged sword in radiation-induced lung injury[J]. Thoracic Cancer, 2018, 9(2):208-217.
47	Wang R, Zhu CZ, Qiao P, et al. Experimental treatment of radiation pneumonitis with human umbilical cord mesenchymal stem cells[J]. Asian Pac J Trop Med, 2014, 7(4):262-266.
48	Xu S, Cong C, Ji HL. Concise review: therapeutic potential of the mesenchymal stem cell derived secretome and extracellular vesicles for Radiation-Induced lung injury: progress and hypotheses[J]. Stem Cells Transl Med, 2019, 8(4):344-354.
49	Xu T, Zhang Y, Chang P, et al. Mesenchymal stem cell-based therapy for radiation-induced lung injury[J]. Stem Cell Res Ther, 2018, 9(1):18.

[1]	Yan Wang, Jianxiong Ma, Shuang Lang, Benchao Dong, Aixian Tian, Yan Li, Lei Sun, Hongzhen Jin, Bin Lu, Ying Wang, Haohao Bai, Xinlong Ma. Research progress in application of exosomes in diagnosis and treatment of osteoporosis [J]. Chinese Journal of Joint Surgery(Electronic Edition), 2023, 17(05): 673-678.
[2]	Yangwenxiang Wei, Haoran Huang, Yuhao Liu, Zhenqiu Chen, Haibin Wang, Chi Zhou. Outlooks and challenges in cell therapy of osteonecrosis of femoral head [J]. Chinese Journal of Joint Surgery(Electronic Edition), 2023, 17(05): 694-700.
[3]	Jinglong He, Wei Sun, Minghong Gao, Wei Xie, Luogong Jiang, Qifei He, Jiaji Yue. Research progress of exosomal non-coding RNA in pathogenesis of osteoarthritis [J]. Chinese Journal of Joint Surgery(Electronic Edition), 2023, 17(04): 520-527.
[4]	Wenrong Dai, Lijuan Zhao, Zhihui Li. Research progress of influence of extracellular vesicles on embryo implantation [J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2023, 19(05): 616-620.
[5]	Lei Gao, Fang Li, Bayaliga, Quan Li, Te Ba. Progress of immune role of stem cell-derived exosomes in wound repair [J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2023, 18(04): 364-367.
[6]	Yingjun Tang, Huajuan Li, Saini Wang, Wang Xu, Feng Liu, Xi Li, Xinbao Hao, Huaping Huang. Effect and mechanism of human umbilical cord mesenchymal stem cells (HU-MSCs) transplantation on emphysema mice [J]. Chinese Journal of Lung Diseases(Electronic Edition), 2023, 16(04): 476-480.
[7]	Ye Li, Jie He, Jinxiu Hu, Jinxiang Wang, Chuan Tian, Hang Pan, Mengdie Chen, Xiaojuan Zhao, Li Ye, Min Zhang, Xinghua Pan. Highly active mesenchymal stem cells interfere with ovarian aging in macaques [J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2023, 13(04): 210-219.
[8]	Huiling Long, Mi Lin, Ting Shao. Research progress and application of three-dimensional spherical mesenchymal stem cell culture technology [J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2023, 13(04): 229-234.
[9]	Wenhui Liu, Tao Wu, Xi Zhang. Advances in mesenchymal stem cells combined with thrombopoietin receptor agonists in platelet recovery after allogeneic hematopoietic stem cell transplantation [J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2023, 13(04): 242-246.
[10]	Hongmin Wang, Yunbo Xie, Yanhu Wang, Fusheng Wang. The advance of clinical research in mesenchymal stem cell treatment for COVID-19 [J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2023, 13(04): 247-256.
[11]	Fuhao Qin, Zheng Zheng, Bin Jiang. Research progress of mesenchymal stem cells in the treatment of perianal fifistulizing Crohn's disease [J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2023, 13(03): 172-177.
[12]	Jiuli Yuan, Dan Liu, Linli Li, Jinyu Liu. Basic research and clinical application of hair follicle-derived mesenchymal stem cells [J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2023, 13(03): 189-192.
[13]	Chufeng Wang, An Jiang. Molecular diagnosis of primary liver cancer [J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2023, 12(05): 499-503.
[14]	Yunzhao Yang, Cheng Zhou, Meihan Shi, Jing Zhao, Xueyuan Bai. Therapeutic effect of human amniotic fluid-derived mesenchymal stem cells on membranous nephropathy in rats [J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2023, 12(04): 181-186.
[15]	Yanqi Song, Xuejing Ren, Wenjuan Wang, Qiuxia Han, Yue Xu, Kaiting Zhuang, Tuo Xiao, Guangyan Cai. Effect of mesenchymal stem cells on ferroptosis in cisplatin-induced acute kidney injury of mice [J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2023, 12(04): 187-193.

Please choose a citation manager

Content to export