Immunomodulatory properties of mesenchymal stem cell-derived exosomes and its application in autoimmune inflammatory diseases treatment

doi:10.3877/cma.j.issn.2095-1221.2020.04.009

Abstract

Abstract:

Exosomes derived from mesenchymal stem cells (MSCs) carry bioactive substances of parental cells, which have similar biological functions to MSCs. The recent studies show that MSC-derived exosomes play an important role in immune regulation by influencing immune cells in nonspecific and acquired immunity, and have a promising future in treatment of different autoimmune inflammatory diseases. In this paper, the immunomodulatory properties of MSCs-derived exosomes and their application in autoimmune diseases are reviewed, providing novel insights for the treatment of autoimmune inflammatory diseases.

Key words: Mesenchymal stem cells, Exosome, Immunoregulation

Xufeng Peng. Immunomodulatory properties of mesenchymal stem cell-derived exosomes and its application in autoimmune inflammatory diseases treatment[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2020, 10(04): 246-250.

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References 38

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外泌体来源	疾病（模型）	应用方式	外泌体用量	作用机理	参考文献
人胚胎干诱导来源的MSCs	颞下颌关节炎（SD大鼠）	局部注射	100 μg	AKT，ERK，AMPK信号通路激活	[34]
鼠脂肪来源MSCs	肥胖患者脂肪慢性炎症（C57BL/6小鼠）	腹腔注射	30 μg	诱导巨噬细胞向M2转化	[19]
人骨髓来源MSCs	慢性移植物抗宿主疾病（Balb/c小鼠）	尾静脉注射	100 μg	诱导调节性T细胞产生抑制辅助性T细胞17，减少CD4⁺ T细胞渗透	[35]
人骨髓来源MSCs	1型糖尿病，葡萄膜视网膜炎（C57BL/6J小鼠）	尾静脉注射	30 μg	抑制抗原提呈细胞、辅助T细胞17激活	[36]
人骨髓来源MSCs	哮踹患者外周血单核细胞	培养基	-	上调TGF-β1和IL-10，促进调节性T细胞增殖和免疫抑制功能	[37]
人胚胎干诱导来源的MSCs	同种异体皮肤移植（C57BL/6J和BALB/cJ小鼠）	皮下注射	0.3 μg	增加调节性T细胞数量	[38]
人脐带来源MSCs	烧伤导致的过度炎症反应（SD大鼠）	尾静脉注射	800 μg	miRNA-181c抑制TLR4信号通路	[17]

外泌体来源	疾病（模型）	应用方式	外泌体用量	作用机理	参考文献
人胚胎干诱导来源的MSCs	颞下颌关节炎（SD大鼠）	局部注射	100 μg	AKT，ERK，AMPK信号通路激活	[34]
鼠脂肪来源MSCs	肥胖患者脂肪慢性炎症（C57BL/6小鼠）	腹腔注射	30 μg	诱导巨噬细胞向M2转化	[19]
人骨髓来源MSCs	慢性移植物抗宿主疾病（Balb/c小鼠）	尾静脉注射	100 μg	诱导调节性T细胞产生抑制辅助性T细胞17，减少CD4⁺ T细胞渗透	[35]
人骨髓来源MSCs	1型糖尿病，葡萄膜视网膜炎（C57BL/6J小鼠）	尾静脉注射	30 μg	抑制抗原提呈细胞、辅助T细胞17激活	[36]
人骨髓来源MSCs	哮踹患者外周血单核细胞	培养基	-	上调TGF-β1和IL-10，促进调节性T细胞增殖和免疫抑制功能	[37]
人胚胎干诱导来源的MSCs	同种异体皮肤移植（C57BL/6J和BALB/cJ小鼠）	皮下注射	0.3 μg	增加调节性T细胞数量	[38]
人脐带来源MSCs	烧伤导致的过度炎症反应（SD大鼠）	尾静脉注射	800 μg	miRNA-181c抑制TLR4信号通路	[17]

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