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中华细胞与干细胞杂志(电子版) ›› 2023, Vol. 13 ›› Issue (01) : 53 -57. doi: 10.3877/cma.j.issn.2095-1221.2023.01.007

综述

作为胰腺癌生物标志物的外泌体内容物研究进展
李新雄1, 张再重1, 赵虎1, 肖春红1, 王烈1,()   
  1. 1. 350025 福州,福建福州厦门大学附属东方医院/联勤保障部队第900医院普通外科
  • 收稿日期:2022-06-25 出版日期:2023-02-01
  • 通信作者: 王烈
  • 基金资助:
    福建省自然科学基金(2021J011262,2022J011095)

Progress of exosome contents as diagnostic markers for pancreatic cancer

Xinxiong Li1, Zaizhong Zhang1, Hu Zhao1, Chunhong Xiao1, Lie Wang1,()   

  1. 1. Department of General Surgery, Dongfang Hospital Affiliated to Xiamen University/900th Hospital of Joint Logistics Support Force, Fuzhou 350025, China
  • Received:2022-06-25 Published:2023-02-01
  • Corresponding author: Lie Wang
引用本文:

李新雄, 张再重, 赵虎, 肖春红, 王烈. 作为胰腺癌生物标志物的外泌体内容物研究进展[J/OL]. 中华细胞与干细胞杂志(电子版), 2023, 13(01): 53-57.

Xinxiong Li, Zaizhong Zhang, Hu Zhao, Chunhong Xiao, Lie Wang. Progress of exosome contents as diagnostic markers for pancreatic cancer[J/OL]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2023, 13(01): 53-57.

胰腺癌作为恶性程度极高且生存期极低的肿瘤,严重威胁患者健康。缺乏敏感、特异的诊断标志物及预后监测指标是影响生存的重要原因之一。作为细胞分泌的重要介质之一,外泌体内容物组成丰富,且具有明显的组织特异性。通过筛选胰腺癌患者外泌体内容物中特异表达的生物标志分子,并在临床队列中评估其诊断价值,对于胰腺癌患者早期诊断和预后评估等方面具有广阔的应用前景。本文主要就近几年作为胰腺癌诊断标志物的外泌体内容物类型研究进展作一综述。

Pancreatic cancer, a tumor with very high malignancy and extremely low survival, seriously threatens patients' health. The lack of sensitive, specific diagnostic markers and prognostic monitoring is one of the important factors affecting survival. As one of the important mediators of cell secretion, exosome contents are rich in composition and have apparent tissue specificity. Screening biomarker molecules expressed explicitly in exosome contents of pancreatic cancer patients and evaluating their diagnostic value in clinical cohorts, has broad application prospects for early diagnosis and prognosis assessment of pancreatic cancer patients. This article mainly reviews the research progress of exosome content types as diagnostic markers for pancreatic cancer in recent years.

表1 开展临床研究的胰腺癌相关外泌体标志物
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