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中华细胞与干细胞杂志(电子版) ›› 2018, Vol. 08 ›› Issue (03) : 152 -155. doi: 10.3877/cma.j.issn.2095-1221.2018.03.005

所属专题: 文献

论著

缺血性脑梗死与颈动脉斑块、嗜酸性粒细胞、血小板CD62p水平的临床相关性研究
郭立斌1, 施宛辰2, 刘英3,()   
  1. 1. 136000 四平市中心人民医院神经内科
    2. 132013 吉林医药学院预防医学系
    3. 吉林省组织工程实验室
  • 收稿日期:2017-11-15 出版日期:2018-06-01
  • 通信作者: 刘英

Clinical correlation between acute ischemic stroke, eosinophil, carotid artery, plaque CD62p level

Libin Guo1, Wanchen Shi2, Ying Liu3,()   

  1. 1. Department of Neurology, the Central Hospital of Siping, Siping 136000, China
    2. Department of Preventive Medicine, Jilin Medical College, Jilin 132013, China
    3. Key Laboratory of Tissue Engineering of Jilin Province, the Central Hospital of Siping, Siping 136000, China
  • Received:2017-11-15 Published:2018-06-01
  • Corresponding author: Ying Liu
  • About author:
    Corresponding author: Liu Ying, Email:
引用本文:

郭立斌, 施宛辰, 刘英. 缺血性脑梗死与颈动脉斑块、嗜酸性粒细胞、血小板CD62p水平的临床相关性研究[J]. 中华细胞与干细胞杂志(电子版), 2018, 08(03): 152-155.

Libin Guo, Wanchen Shi, Ying Liu. Clinical correlation between acute ischemic stroke, eosinophil, carotid artery, plaque CD62p level[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2018, 08(03): 152-155.

目的

探讨急性缺血性脑梗死初发与再发与颈动脉斑块、嗜酸性粒细胞水平与血小板活化水平之间的相关性。

方法

本研究选取50例被诊断为急性缺血性脑梗死的患者,患者均进行颈部血管超声检查,根据有无颈动脉斑块分为2组,均进行嗜酸性粒细胞、血小板活性CD62p水平等指标检测。两组间比较采用t检验。

结果

有颈动脉斑块形成的急性缺血性脑梗死患者,其嗜酸性粒细胞计数低于无颈动脉斑块患者(P < 0.05),而其血浆CD62p水平高于无颈动脉斑块患者(P < 0.05),1年随访中复发率更高(P < 0.05)。

结论

急性缺血性脑梗死患者的初发与复发与颈动脉斑块存在,嗜酸性粒细胞计数及CD62p水平密切相关。

Objective

To investigate the correlation between eosinophil count, carotid plaque CD62p level and the prognosis of acute ischemic stroke.

Methods

50 patients diagnosed as having acute ischemic stroke were include in this study. The patients were divided into 2 groups according to whether there were carotid plaques. All of them were examined by ultrasonography of neck vessels, eosinophil and CD62p level. The t test was used for comparison between the two groups.

Results

There was no significant difference in the baseline characteristics between two groups (P > 0.05). Stroke patients with carotid plaque formation had a significantly lower eosinophil count than did patients without carotid artery plaque(P <0.05), with a higher plasma level of CD62p (P< 0.05) and more recurrence in 1 year follow-up(P < 0.05).

Conclusion

Carotid plaque, the level of eosinophil and CD62p in acute ischemic stroke are closely related to the recurrence of the acute ischemic stroke.

表1 两组患者一般资料比较
表2 两组患者血脂水平比较(±s,mmol/L)
表3 两组患者嗜酸性粒细胞与CD62p的变化(±s
表4 两组患者随访再发比较(n = 25)
1
Jiang B, Wang WZ, Chen H, et al. Incidence and trends of stroke and its subtypes in China:results from three large cities[J]. Stroke, 2006, 37(1):63-68.
2
Zhang LF, Yang J, Hong Z, et al. Proportion of different subtypes of stroke in China[J]. Stroke, 2003, 34(9):2091-2096.
3
卫生部疾病控制司 中华医学会神经病分会. 中国脑血管病防治指南(节选)[J]. 2007, 7(1):17.
4
吴兆苏,姚崇华,赵冬, 等. 我国多省市心血管病趋势及决定因素的人群监测(中国MONICA方案)[J]. 中华心血管病杂志, 1997, 25(1):6-11.
5
中华医学会神经病分会脑血管病学组.《中国脑血管病防治指南》节选[J].中国慢性病预防与控制, 2006, 14(2):143-145.
6
Audebert HJ, Pellkofer TS, Wimmer ML, et al. Progression in lacunar stroke is related to elevated acute phase parameters[J]. Eur Neurol, 2004, 51(3):125-131.
7
王振义, 李家增, 阮长耿, 等. 血栓与止血基础理论与临床[M]. 3版. 上海:上海科学技术出版社, 2004: 54-80.
8
Michelson AD. Evaluation of platelet function by flow cytometry[J]. Pathophysiol Haemost Thromb, 2006, 35(1-2):67-82.
9
Sakai T, Inoue S, Matsuyama TA, et al. Eosinophils may be involved in thrombus growth in acute coronary syndrome[J]. Int Heart J, 2009, 50(3):267-277.
10
Jiang P, Wang DZ, Ren YL, et al. Significance of eosinophil accumulation in the thrombus and decrease in peripheral blood in patients with acute coronary syndrome[J]. Coron Artery Dis, 2015, 26(2):101-106.
11
Wang Q, Zhao W, Bai S. Association between plasma soluble P-selectin elements and progressive ischemic stroke[J]. Exp Ther Med, 2013, 5(5):1427-1433.
12
Guo LB, Liu S, Zhang F, et al. The role of eosinophils in stroke:a pilot study[J]. Eur Rev Med Pharmacol Sci, 2015, 19(19):3643-3648.
13
Sun L, Kuroiwa T, Ishibashi S, et al. Time profile of eosinophilic neurons in the cortical layers and cortical atrophy[J]. Acta Neurochir Suppl, 2006, 96:272-275.
14
Arikanoglu A, Yucel Y, Acar A, et al. The relationship of the mean platelet vol-ume and C-reactive protein levels with mortality in ischemic stroke patients[J]. Eur Rev Med Pharmacol Sci, 2013, 17(13):1774-1777.
15
Narantuya D, Nagai A, Sheikh AM, et al. Human microglia transplanted in rat focal ischemia brain induce neuroprotection and behavioral improvement[J]. PLoS One, 2010,5(7): e11746.
16
Bustamante A, Sobrino T, Giralt D, et al. Prognostic value of blood interleukin-6 in the prediction of functional outcome after stroke: a systematic review and meta-analysis[J]. J Neuroimmunol, 2014, 274(1-2): 215-224.
17
Marousi S, Ellul J, Antonacopoulou A, et al. Functional polymorphisms of interleukin 4 and interleukin 10 may predict evolution and functional outcome of an ischaemic stroke[J]. Eur J Neurol, 2011, 18(4): 637-643.
18
André P, Hartwell D, Hrachovinová I, et al. Pro-coagulant state resulting from high levels of soluble P-selectin in blood[J]. Proc Natl Acad Sci USA, 2000, 97(25):13835-13840.
19
Sakai T, Inoue S, Matsuyama TA, et al. Eosinophils may be involved in thrombus growth in acute coronary syndrome[J]. Int Heart J, 2009, 50(3):267-277.
20
Jiang P, Wang DZ, Ren YL, et al. Significance of eosinophil accumulation in the thrombus and decrease in peripheral blood in patients with acute coronary syndrome[J]. Coron Artery Dis, 2015, 26(2):101-106.
21
Essani NA, McGuire GM, Manning AM, et al. Differential induction of mRNA for ICAM-1 and selectins in hepatocytes, Kupffer cells and endothelial cell during endotoxemia[J]. Biochem Biophys Res Commun, 1995, 211(1):74-82.
22
Wang HB, Wang JT, Zhang L, et al. P-selectin primes leukocyte integrin activation during inflammation[J]. Nat Immunol, 2007, 8(8):882-892.
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