淋巴细胞亚群成员研究进展

doi:10.3877/cma.j.issn.2095-1221.2017.03.009

淋巴细胞是人体重要的免疫细胞，占外周血白细胞总数的20﹪~ 45﹪，主要分为T细胞、B细胞和NK细胞三大类。根据细胞表面标志及功能特征，将淋巴细胞亚群分为CD3⁺ CD4⁺辅助性T细胞、CD3⁺CD8⁺的细胞毒性T细胞、CD19⁺ B细胞、CD16⁺ CD56⁺ NK细胞。随着基础免疫学及免疫学技术的不断发展，临床和科研工作者不断地将淋巴细胞亚群细化并发现一些新的亚群，包括γδT细胞、Th1/Th2细胞、Th17细胞、Th9细胞、Tfh细胞、Treg细胞、Breg细胞、NKT细胞和NKB细胞等，淋巴细胞亚群的内容也随之被赋予了新的定义，现将近年来淋巴细胞亚群的研究进展进行综述。

关键词: T淋巴细胞亚群, B淋巴细胞亚群, 杀伤细胞，天然, 淋巴细胞亚群

Lymphocytes are very important immune cells in the body, accounting for 20﹪ ~ 45﹪ of peripheral leukocytes. The three major subpopulation of lymphocytes are T cells, B cells and NK cells. According to different surface markers and functional characteristics, lymphocytes are mainly divided into CD3⁺ CD4⁺ helper T cells, CD3⁺ CD8⁺ cytotoxic T cells, CD19⁺ B cells and CD16⁺ CD56⁺ NK cells. With the development of basic immunology and immunological techniques, new lymphocyte subsets are proposed, including gamma delta T cells, Th1/Th2 cells, Th17 cells, Th9 cells, Tfh cells, Treg cells, Breg cells, NKT cells, NKB cells, etc.The definition of lymphocyte subsets are refined constantly. The present review summarizes recent research progress of lymphocyte subsets.

Key words: T lymphocyte subsets, B lymphocyte subsets, Killer cells, natural, Lymphocyte subsets

表1 淋巴细胞亚群成员

成员	淋巴细胞亚群类别	淋巴细胞亚群的细分	淋巴细胞特殊亚群
T细胞	CD4⁺ T细胞（Th）	γδ T细胞	NKT细胞
	CD8⁺ T细胞（Tc）	αβ T细胞（Th、Tc）
		Th（Th1/Th2/Th17/Tfh/Treg/Th9/Th22）
		Tc（另CD8⁺ Treg、DNT）
B细胞	CD3^- CD19⁺ B细胞	B1、B2、另Breg	NKB细胞
NK细胞	CD3^- CD16⁺ CD56⁺	CD56 dim NK细胞
	NK细胞	CD56 bright NK细胞

表1 淋巴细胞亚群成员

成员	淋巴细胞亚群类别	淋巴细胞亚群的细分	淋巴细胞特殊亚群
T细胞	CD4⁺ T细胞（Th）	γδ T细胞	NKT细胞
	CD8⁺ T细胞（Tc）	αβ T细胞（Th、Tc）
		Th（Th1/Th2/Th17/Tfh/Treg/Th9/Th22）
		Tc（另CD8⁺ Treg、DNT）
B细胞	CD3^- CD19⁺ B细胞	B1、B2、另Breg	NKB细胞
NK细胞	CD3^- CD16⁺ CD56⁺	CD56 dim NK细胞
	NK细胞	CD56 bright NK细胞

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Research progress in members of lymphocyte subsets

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