Objective To explore the value of Myeloid-derived suppressor cell (MDSC) level in peripheral blood, neutrophil to lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) in guiding clinical prognosis evaluation of patients with colorectal cancer.
Methods 183 patients with colorectal cancer and 50 health examinees admitted to our hospital from May 2013 to May 2018 were enrolled in the patient group and the control group respectively. The levels of MDSC and the ratio of NLR to PLR in peripheral blood of patients before and after treatment were measured. The changes of the above indexes in patients before and after treatment were recorded, and the differences of the above indexes in patients with effective and ineffective treatment before treatment were compared. Chi-square test, t-test and receiver operating characteristic (ROC) were used for statistical analysis.
Results Before treatment, the ratio of MDSC, NLR and PLR in patients group were (4.26±0.99) ﹪, (3.05±0.59) , (146.45±29.71) respectively, which were higher than those in the control group (0.71 ±0.15) ﹪, (1.62 ±0.37) , (90.92 ±13.88) . The difference was statistically significant (t?= 25.238, 16.272, 12.824, P all < 0.05) . The ratio of MDSC, NLR and PLR decreased one month after treatment, and the difference was statistically significant (P < 0.05) . Among 183 patients, 111 cases were included in the effective treatment group and 72 cases were included in the ineffective treatment group. The ratio of MDSC, NLR and PLR in the effective group before treatment were (4.06±0.61) ﹪, (2.73±0.40) , (136.18±26.11) , respectively, which were lower than those in the ineffective group (4.57±0.42) ﹪, (3.54±0.31) , (162.29±18.64) , respectively (t?= 6.202, 14.572, 7.353, P all < 0.05) . ROC curve showed that the area under the curve of MDSC (> = 4.22﹪) , NLR (> = 3.21) , PLR (> = 151.60) before treatment was 0.909 (P < 0.05) .
Conclusion The level of MDSC and the ratio of NLR to PLR of the peripheral blood in patients with colorectal cancer are significantly increased, and the higher MDSC level and the ratio of NLR to PLR imply poor prognosis.
