Molecular mechanisms and interventional strategies of hematopoietic stem cell aging

doi:10.3877/cma.j.issn.2095-1221.2026.01.005

Abstract

Abstract:

The aging of hematopoietic stem cells (HSCs) is the result of the combined effects of intrinsic cellular senescence programs and changes in the hematopoietic microenvironment, which is characterized by diminished self-renewal capacity, myeloid differentiation bias, homing and colonization defects, and the reduction of clonal diversity, etc. These functional declines significantly increase the risk of malignant blood disorders and various aging-related diseases. The application of technologies such as single-cell RNA sequencing, epigenomic mapping, and gene editing has not only elucidated the core mechanisms of HSCs aging such as gene damage, epigenetic alterations and changes in the hematopoietic microenvironment, but also led to the proposal of multiple strategies for HSCs rejuvenation. This review systematically summarizes recent advances in HSCs aging research, aiming to identify key regulatory nodes and potential intervention targets, providing a solid theoretical foundation and technical prospects for the prevention and treatment of related aging diseases.

Key words: Hematopoietic stem cells, Aging, Molecular mechanisms

Wen Wu, Zhenyu Zhou. Molecular mechanisms and interventional strategies of hematopoietic stem cell aging[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2026, 16(01): 39-44.

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https://zhxbygxbzz.cma-cmc.com.cn/EN/Y2026/V16/I01/39

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