Progress of total pancreatectomy with islet autotransplantation: a multicenter prospective observational study (POST)

doi:10.3877/cma.j.issn.2095-1221.2025.04.007

Abstract

Abstract:

Total pancreatectomy with islet autotransplantation (TPIAT) is the preferred treatment for debilitating chronic pancreatitis (CP) and recurrent acute pancreatitis (RAP) in adults and children who have failed pharmacological and endoscopic therapies. This approach has been practiced in Europe and the United States for nearly 50 years. In 2014, Professor Bellin initiated a large-scale multicenter prospective observational study (POST) on TPIAT to systematically investigate the key questions regarding the patient selection, risks of persistent pain and disability, diabetes risk, optimal timing for surgery, intervention strategies, and the economic viability of the procedure, publishing a series of research works. This review outlines the background of the POST and its published research findings, and also reviewed the results of other teams' research surrounding these directions, aiming to enhance healthcare professionals' understanding of TPIAT technology and its advancements, thereby provide reference for the development of clinical TPIAT work in China.

Key words: Total pancreatectomy, Islet autotransplantation, Chronic pancreatitis, Recurrent acute pancreatitis, Prospective study

Hongxing Fu, Honghua Wang, Guilin Xie, Sheng Yan. Progress of total pancreatectomy with islet autotransplantation: a multicenter prospective observational study (POST)[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2025, 15(04): 238-244.

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URL: https://zhxbygxbzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2095-1221.2025.04.007

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References 87

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序号	研究方案中规定的目的
1	（1a）确定与TPIAT术后良好的疼痛和健康相关的生活质量结局相关的患者情况和疾病特征；（1b）TPIAT干预的最佳时机，以解决疼痛并改善生活质量；（1c）在部分患者中，中枢敏化对缓解疼痛的影响。
2	（2a）确定与IAT术后良好的血糖结果相关的患者情况和疾病特征；（2b）TPIAT手术后能获得胰岛素脱离的最佳手术时机。
3	确定TPIAT的成本效益。

序号	研究方案中规定的目的
1	（1a）确定与TPIAT术后良好的疼痛和健康相关的生活质量结局相关的患者情况和疾病特征；（1b）TPIAT干预的最佳时机，以解决疼痛并改善生活质量；（1c）在部分患者中，中枢敏化对缓解疼痛的影响。
2	（2a）确定与IAT术后良好的血糖结果相关的患者情况和疾病特征；（2b）TPIAT手术后能获得胰岛素脱离的最佳手术时机。
3	确定TPIAT的成本效益。

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