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Chinese Journal of Cell and Stem Cell(Electronic Edition) ›› 2022, Vol. 12 ›› Issue (04): 250-256. doi: 10.3877/cma.j.issn.2095-1221.2022.04.009

• Review • Previous Articles    

Strategies for target selection in TCR-T therapy

Suxin Wu1, Yunbin Ye1,()   

  1. 1. the School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350014, China; Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Tumor Immunology Laboratory, Fuzhou 350014, China; Fujian Provincial Key Laboratory of Translational Cancer Medicine, Fuzhou 350014, China
  • Received:2022-04-29 Online:2022-08-01 Published:2022-10-14
  • Contact: Yunbin Ye

Abstract:

T cell receptor-engineered T cell (TCR-T) therapy is one of the hot spots in the field of adoptive cell immunotherapies for cancer. In recent years, TCR-T therapy has made breakthrough progress and is playing an increasingly important role in the cancer therapy. Here, we analyze the role of different kinds of tumor antigens on the effectivity of TCR-T therapy by reviewing the current progress of TCR-T in basic researches and clinical trials, so as to provide new ideas for cellular immunotherapy to cancer.

Key words: Tumor antigen, TCR-T, Adoptive cellular immunotherapy

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