Research progress in human mesenchymal stem cells as treatment for systemic sclerosis

doi:10.3877/cma.j.issn.2095-1221.2021.06.009

Abstract

Abstract:

Systemic sclerosis (SSc) is a rare autoimmune disease that affects multiple organs throughout the body. Due to a poor understanding of the etiology and pathogenesis of SSc, at present, symptomatic treatment is commonly used. With the continuous exploration of stem-cell research, the value of stem cell therapy in the medical field is increasingly highlighted. There is increasing evidence to suggest that stem cells as an effective means with strong differentiation and regenerative potential gradually show good results in the treatment of SSc patients. In this review, in order to provide a more solid basis, we compared and looked forward to the research progress in three common sources of human mesenchymal stem cells (hMSCs) including bone marrow hMSCs, adipose-derived hMSCs and umbilical cord-derived hMSCs in the treatment of patients with SSc.

Key words: Systemic sclerosis, Human mesenchymal stem cells, Treatment

Jiehan Cui, Jun Ma, Yongzhou Song, Aijing Liu. Research progress in human mesenchymal stem cells as treatment for systemic sclerosis[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2021, 11(06): 378-382.

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