Research progress in clearance of apoptotic cells and maintenance of tissue homeostasis

doi:10.3877/cma.j.issn.2095-1221.2018.04.011

Abstract

Abstract:

When tissues and organs are suffering from damage, the apoptosis of damaged cells along with the clearance of such debris has contributed a lot to tissue regeneration. The underlying mechanism of how apoptotic debris promotes regeneration of damaged tissues and organs has always been a research hotspot. Recent studies have showed that macrophages play an important role in clearing apoptotic cells, maintaining homeostasis, and promoting tissue regeneration. This review summarizes recent studies from three aspects: the apoptotic signaling pathway, the polarization characteristics of macrophages, and the interaction between apoptotic cells and macrophages.

Key words: Apoptosis, Macrophages, Tissue regeneration

Qingyuan Ye, Shiyu Liu, Yan Jin. Research progress in clearance of apoptotic cells and maintenance of tissue homeostasis[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2018, 08(04): 248-251.

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References 44

1	Reed JC. Apoptosis-based therapies[J]. Nat Rev Drug Discov, 2002, 1(2):111-121.
2	Jacobson MD,Weil M,Raff MC. Programmed cell death in animal development[J]. Cell, 1997, 88(3):347-354.
3	Bartneck M,Fech V,Ehling J, et al. Histidine-Rich glycoprotein promotes macrophage activation and inflammation in chronic liver disease[J]. Hepatology, 2016, 63(4):1310-1324.
4	Murray PJ. Macrophage Polarization[J]. Annu Rev Physiol, 2017, 79: 541-566.
5	Wang X. The expanding role of mitochondria in apoptosis[J]. Genes Dev, 2001, 15(22):2922-2933.
6	Hsu YT,Wolter KG,Youle RJ. Cytosol-to-membrane redistribution of Bax and Bcl-X(L)during apoptosis[J]. Proc Natl Acad Sci U S A, 1997, 94(8):3668-3672.
7	Wolter KG,Hsu YT,Smith CL, et al. Movement of Bax from the cytosol to mitochondria during apoptosis[J]. J Cell Biol, 1997, 139(5):1281-1292.
8	Wang C. Youle RJ. The role of mitochondria in apoptosis[J]. Annu Rev Genet, 2009, 43: 95-118.
9	Ashkenazi A,Dixit VM. Death receptors:signaling and modulation[J]. Science, 1998, 281(5381):1305-1308.
10	Oshimi Y,Oda S,Honda Y, et al. Involvement of Fas ligand and Fas-mediated pathway in the cytotoxicity of human natural killer cells[J]. J Immunol, 1996, 157(7):2909-2915.
11	Peter ME,Krammer PH. The CD95(APO-1/Fas)DISC and beyond[J]. Cell Death Differ, 2003, 10(1):26-35.
12	Nagata S. Fas ligand-induced apoptosis[J]. Annu Rev Genet, 1999, 33: 29-55.
13	Li H,Zhu H,Xu CJ, et al. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis[J]. Cell, 1998, 94(4):491-501.
14	Banjerdpongchai R,Kongtawelert P,Khantamat O, et al. Mitochondrial and endoplasmic reticulum stress pathways cooperate in zearalenone-induced apoptosis of human leukemic cells[J]. J Hematol Oncol, 2010, 3:50.
15	Logue SE,Cleary P,Saveljeva S, et al. New directions in ER stress-induced cell death[J]. Apoptosis, 2013, 18(5):537-546.
16	Van Furth R,Cohn ZA,Hirsch JG, et al. The mononuclear phagocyte system:a new classification of macrophages,monocytes,and their precursor cells[J]. Bull World Health Organ, 1972, 46(6):845-852.
17	Ginhoux F,Guilliams M. Tissue-Resident macrophage ontogeny and homeostasis[J]. Immunity, 2016, 44(3):439-449.
18	Goubau D,Deddouche S,Reis e Sousa C. Cytosolic sensing of viruses[J]. Immunity, 2013, 38(5):855-869.
19	Glass CK. Natoli G. Molecular control of activation and priming in macrophages[J]. Nat Immunol, 2016, 17(1):26-33.
20	O'Shea JJ,Murray PJ. Cytokine signaling modules in inflammatory responses[J]. Immunity, 2008, 28(4):477-487.
21	Luu K,Greenhill CJ,Majoros A, et al. STAT1 plays a role in TLR signal transduction and inflammatory responses[J]. Immunol Cell Biol, 2014, 92(9):761-769.
22	Gause WC,Wynn T,Allen JE. Type 2 immunity and wound healing:evolutionary refinement of adaptive immunity by helminths[J]. Nat Rev Immunol, 2013, 13(8):607-614.
23	Locksley RM. Asthma and allergic inflammation[J]. Cell, 2010, 140(6):777-783.
24	Gordon S. Martinez FO. Alternative activation of macrophages: mechanism and functions[J]. Immunity, 2010, 32(5):593-604.
25	Vannella KM,Wynn TA. Mechanisms of organ injury and repair by macrophages[J]. Annu Rev Physiol, 2017, 79: 593-617.
26	Stramer BM,Mori R,Martin P. The inflammation-fibrosis Link? A Jekyll and Hyde role for blood cells during wound repair[J]. J Invest Dermatol, 2007, 127(5):1009-1017.
27	Godwin JW,Pinto AR,Rosenthal NA. Macrophages are required for adult salamander limb regeneration[J]. Proc Natl Acad Sci U S A, 2013, 110(23):9415-9420.
28	Garza-Garcia AA,Driscoll PC,Brockes JP. Evidence for the local evolution of mechanisms underlying limb regeneration in salamanders[J]. Integr Comp Biol, 2010, 50(4):528-535.
29	Kumar A,Gates PB,Czarkwiani A, et al. An orphan gene is necessary for preaxial digit formation during salamander limb development[J]. Nat Commun, 2015, 6:8684.
30	Mounier R,Theret M,Arnold L, et al. AMPK alpha 1 Regulates Macrophage Skewing at the Time of Resolution of Inflammation during Skeletal Muscle Regeneration[J]. Cell Metab, 2013, 18(2):251-264.
31	Henson PM. Cell Removal: Efferocytosis[J]. Annu Rev Cell Dev Biol, 2017, 33:127-144.
32	Nagata S. Apoptosis and Clearance of Apoptotic Cells[J]. Annu Rev Immunol, 2018, 36: 489-517.
33	Nakaya M,Tanaka M,Okabe Y, et al. Opposite effects of rho family GTPases on engulfment of apoptotic cells by macrophages[J]. J Biol Chem, 2006, 281(13):8836-8842.
34	Henson PM,Bratton DL. Antiinflammatory effects of apoptotic cells[J]. J Clin Invest, 2013, 123(7):2773-2774.
35	Petrie TA,Strand NS,Yang CT, et al. Macrophages modulate adult zebrafish tail fin regeneration[J]. Development, 2014, 141(13):2581-2591.
36	Bosurgi L, Cao YG, Cabeza-Cabrerizo M, et al. Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells[J]. Science, 2017, 356(6342):1072-1076.
37	Feng MY,Marjon KD,Zhu FA, et al. Programmed cell removal by calreticulin in tissue homeostasis and cancer[J]. Nat Commun, 2018, 9(1):3194.
38	Heredia JE,Mukundan L,Chen FM, et al. Type 2 innate signals stimulate fibro/adipogenic progenitors to facilitate muscle regeneration[J]. Cell, 2013, 153(2):376-388.
39	Brenner D,Blaser H,Mak TW. Regulation of tumour necrosis factor signalling:live or let die[J]. Nat Rev Immunol, 2015, 15(6):362-374.
40	Hochreiter-Hufford A. Ravichandran KS. Clearing the dead:apoptotic cell sensing,recognition,engulfment,and digestion[J]. Cold Spring Harb Perspect Biol, 2013, 5(1):a008748.
41	Smith TD,Nagalla RR,Chen EY, et al. Harnessing macrophage plasticity for tissue regeneration[J]. Adv Drug Deliv Rev, 2017, 114:193-205.
42	Horckmans M,Ring L,Duchene J, et al. Neutrophils orchestrate post-myocardial infarction healing by polarizing macrophages towards a reparative phenotype[J]. Eur Heart J, 2017, 38(3):187-197.
43	Coakley RJ,Taggart C,Mcelvaney NG, et al. Cytosolic pH and the inflammatory microenvironment modulate cell death in human neutrophils after phagocytosis[J]. Blood, 2002, 100(9):3383-3391.
44	Serhan CN,Savill J. Resolution of inflammation: the beginning programs the end[J]. Nat Immunol, 2005, 6(12):1191-1197.

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