Research advances in the regulatory impact of DETC on inflammatory stage in wound healing and mechanism thereof

doi:10.3877/cma.j.issn.2095-1221.2020.06.011

Abstract

Abstract:

Inflammatory response can not only promote but also inhibit wound healing. Moderate inflammatory response is beneficial to the initiation of an immune response and the production of various growth factors. However, excessive inflammatory response will lead to hyperplastic scars and tissue injury in the body. Dendritic epidermal T lymphocytes (DETCs) , which specifically express the Vγ3δ1TCR, are originated from the thymus of mice and then colonized on the epidermis. In the process of wound healing, DETCs can not only exacerbate the inflammatory response by releasing various chemokines and pro-inflammatory factors, but also alleviate the excessive inflammatory response of the body through anti-inflammatory mediators to promote wound healing.

Key words: DETC, Wound healing, Inflammatory reaction, Cytokine

Cheng Chen, Xiaohong Hu, Guangping Liang, Weifeng He. Research advances in the regulatory impact of DETC on inflammatory stage in wound healing and mechanism thereof[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2020, 10(06): 378-382.

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References 54

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