Current situation and strategies in the treatment of myocardial infarction by adipose-derived stem cells

doi:10.3877/cma.j.issn.2095-1221.2019.01.008

Abstract

Abstract:

Acute myocardial infarction is one of the most common cardiovascular diseases. Due to the insufficiency of coronary artery blood supply, cardiomyocyte death occurs and microenvironment deteriorates, followed by mechanical-electrophysiological dysfunction in early stage and heart failure in long term. At present, treatment of myocardial infarction can improve cardiac function and reduce ventricular remodeling in a certain extent. However, it is difficult to restore cardiac function completely due to the limited regenerative capacity of cardiomyocytes. In recent years, transplantation of adipose-derived stem cells has attracted extensive attention. However, the cell survival and engraftment rate after transplantation are generally low and the therapeutic effect is not ideal. This article reviews the current situation of adipose-derived stem cells in the treatment of acute myocardial infarction and the ways and methods that may improve its therapeutic effect.

Key words: Myocardial infarction, Adipose-derived stem cell, Growth factor, Drug intervention, Scaffold material

Yan Kong, Yuquan Li, Xiangqun Yang. Current situation and strategies in the treatment of myocardial infarction by adipose-derived stem cells[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2019, 09(01): 40-43.

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