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中华细胞与干细胞杂志(电子版) ›› 2018, Vol. 08 ›› Issue (04) : 252 -256. doi: 10.3877/cma.j.issn.2095-1221.2018.04.012

所属专题: 文献

综述

抑癌基因PTEN及其假基因PTENP1在子宫内膜癌中的研究进展
丁智颖1   
  1. 1. 110000 沈阳市,中国医科大学研究生院
    2. 110000 沈阳市,北部战区总医院和平分院病理科
  • 收稿日期:2018-03-28 出版日期:2018-08-01
  • 基金资助:
    辽宁省自然科学基金(20170540908)

Research progress of tumor suppressor gene PTEN and its pseudogene PTENP1 in endometrial carcinoma

Zhiying Ding1   

  1. 1. China Medical University, Shenyang 110000, China
    2. Department of Pathology, General Hospital of Nothern Theator Command, shenyang 110000, China
  • Received:2018-03-28 Published:2018-08-01
  • About author:
    Corresponding author:Ming Jian, Email:
引用本文:

丁智颖. 抑癌基因PTEN及其假基因PTENP1在子宫内膜癌中的研究进展[J/OL]. 中华细胞与干细胞杂志(电子版), 2018, 08(04): 252-256.

Zhiying Ding. Research progress of tumor suppressor gene PTEN and its pseudogene PTENP1 in endometrial carcinoma[J/OL]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2018, 08(04): 252-256.

子宫内膜癌的发病率在逐年上升,引起了人们的广泛关注,但其发病的分子遗传学机制仍不十分清楚。近年来基因改变致癌的研究成为热点。国内外研究报道发现:PTEN(与张力蛋白同源第10染色体丢失的磷酸酶基因)是目前已知的子宫内膜癌中突变率最高的基因,常发生在子宫内膜癌的早期,对其突变的检测有助于子宫内膜癌的早期诊断、治疗及预后评价,并为子宫内膜癌的基因治疗提供了新的靶点。另外,研究发现,PTENP1(PTEN的假基因)转录调控PTEN的表达,被认为与一些肿瘤的发生有关。本文就PTEN基因的结构、功能及在子宫内膜癌中的突变情况、临床意义及PTENP1的研究现状进行综述。

The incidence of endometrial cancer is increasing year by year, which has attracted widespread attention. However, the molecular and genetic mechanismd of endometrial cancer are still unclear. PTEN (phosphatase gene lost on chromosome 10 homologous to tensin) is the gene with the highest mutation rate in endometrial cancer known at present. Detection of its mutation is helpful to early diagnosis, treatment and prognosis evaluation of endometrial cancer and provides a new target for gene therapy of endometrial cancer. In addition, the study found that the transcription of PTENP1 (PTEN's pseudogene) regulates the expression of PTEN, which is believed to be related to the occurrence of some tumors. This article reviews the structure and function of PTEN gene, its mutation in endometrial cancer, its clinical significance and the research status of PTENP1.

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