切换至 "中华医学电子期刊资源库"

中华细胞与干细胞杂志(电子版) ›› 2018, Vol. 08 ›› Issue (04) : 248 -251. doi: 10.3877/cma.j.issn.2095-1221.2018.04.011

所属专题: 文献

综述

凋亡细胞的清除及组织稳态维持的研究进展
叶庆元1, 刘世宇2, 金岩2,()   
  1. 1. 710032 西安,军事口腔医学国家重点实验 口腔疾病国家临床医学研究中心 陕西省口腔疾病国际联合研究中心 第四军医大学口腔医院组织病理学教研室;710032 西安,第四军医大学基础医学院六大队
    2. 710032 西安,军事口腔医学国家重点实验 口腔疾病国家临床医学研究中心 陕西省口腔疾病国际联合研究中心 第四军医大学口腔医院组织病理学教研室
  • 收稿日期:2018-04-25 出版日期:2018-08-01
  • 通信作者: 金岩
  • 基金资助:
    国家自然科学基金资助(31670995)

Research progress in clearance of apoptotic cells and maintenance of tissue homeostasis

Qingyuan Ye1, Shiyu Liu2, Yan Jin2,()   

  1. 1. State Key Laboratory of Military Stomatology &National Clinical Research Center for Oral Diseases & Shanxi Key Laboratory of Oral Diseases, Department of Oral Histology and Pathology, School of Stomatology, the Fourth Military Medical University, Xi'an 710032, China; Sixth Student Brigade, College of Basic Medicine, the Fourth Military Medical University, Xi'an 710032, China
    2. State Key Laboratory of Military Stomatology &National Clinical Research Center for Oral Diseases & Shanxi Key Laboratory of Oral Diseases, Department of Oral Histology and Pathology, School of Stomatology, the Fourth Military Medical University, Xi'an 710032, China
  • Received:2018-04-25 Published:2018-08-01
  • Corresponding author: Yan Jin
  • About author:
    Corresponding Author: Jin Yan, Email:
引用本文:

叶庆元, 刘世宇, 金岩. 凋亡细胞的清除及组织稳态维持的研究进展[J/OL]. 中华细胞与干细胞杂志(电子版), 2018, 08(04): 248-251.

Qingyuan Ye, Shiyu Liu, Yan Jin. Research progress in clearance of apoptotic cells and maintenance of tissue homeostasis[J/OL]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2018, 08(04): 248-251.

机体在组织器官受到损伤时,细胞凋亡和机体对凋亡细胞的清除在组织再生中有着密不可分的联系,其背后促进受损组织器官再生的机制一直是研究热点所在。近期研究发现,巨噬细胞在清除凋亡细胞,维持机体稳态以及促进组织器官修复再生中起到了重要作用。本文主要从凋亡的信号通路、巨噬细胞的极化特点以及凋亡细胞与巨噬细胞的相互作用这3个方面对近期研究进行综述。

When tissues and organs are suffering from damage, the apoptosis of damaged cells along with the clearance of such debris has contributed a lot to tissue regeneration. The underlying mechanism of how apoptotic debris promotes regeneration of damaged tissues and organs has always been a research hotspot. Recent studies have showed that macrophages play an important role in clearing apoptotic cells, maintaining homeostasis, and promoting tissue regeneration. This review summarizes recent studies from three aspects: the apoptotic signaling pathway, the polarization characteristics of macrophages, and the interaction between apoptotic cells and macrophages.

1
Reed JC. Apoptosis-based therapies[J]. Nat Rev Drug Discov, 2002, 1(2):111-121.
2
Jacobson MD,Weil M,Raff MC. Programmed cell death in animal development[J]. Cell, 1997, 88(3):347-354.
3
Bartneck M,Fech V,Ehling J, et al. Histidine-Rich glycoprotein promotes macrophage activation and inflammation in chronic liver disease[J]. Hepatology, 2016, 63(4):1310-1324.
4
Murray PJ. Macrophage Polarization[J]. Annu Rev Physiol, 2017, 79: 541-566.
5
Wang X. The expanding role of mitochondria in apoptosis[J]. Genes Dev, 2001, 15(22):2922-2933.
6
Hsu YT,Wolter KG,Youle RJ. Cytosol-to-membrane redistribution of Bax and Bcl-X(L)during apoptosis[J]. Proc Natl Acad Sci U S A, 1997, 94(8):3668-3672.
7
Wolter KG,Hsu YT,Smith CL, et al. Movement of Bax from the cytosol to mitochondria during apoptosis[J]. J Cell Biol, 1997, 139(5):1281-1292.
8
Wang C. Youle RJ. The role of mitochondria in apoptosis[J]. Annu Rev Genet, 2009, 43: 95-118.
9
Ashkenazi A,Dixit VM. Death receptors:signaling and modulation[J]. Science, 1998, 281(5381):1305-1308.
10
Oshimi Y,Oda S,Honda Y, et al. Involvement of Fas ligand and Fas-mediated pathway in the cytotoxicity of human natural killer cells[J]. J Immunol, 1996, 157(7):2909-2915.
11
Peter ME,Krammer PH. The CD95(APO-1/Fas)DISC and beyond[J]. Cell Death Differ, 2003, 10(1):26-35.
12
Nagata S. Fas ligand-induced apoptosis[J]. Annu Rev Genet, 1999, 33: 29-55.
13
Li H,Zhu H,Xu CJ, et al. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis[J]. Cell, 1998, 94(4):491-501.
14
Banjerdpongchai R,Kongtawelert P,Khantamat O, et al. Mitochondrial and endoplasmic reticulum stress pathways cooperate in zearalenone-induced apoptosis of human leukemic cells[J]. J Hematol Oncol, 2010, 3:50.
15
Logue SE,Cleary P,Saveljeva S, et al. New directions in ER stress-induced cell death[J]. Apoptosis, 2013, 18(5):537-546.
16
Van Furth R,Cohn ZA,Hirsch JG, et al. The mononuclear phagocyte system:a new classification of macrophages,monocytes,and their precursor cells[J]. Bull World Health Organ, 1972, 46(6):845-852.
17
Ginhoux F,Guilliams M. Tissue-Resident macrophage ontogeny and homeostasis[J]. Immunity, 2016, 44(3):439-449.
18
Goubau D,Deddouche S,Reis e Sousa C. Cytosolic sensing of viruses[J]. Immunity, 2013, 38(5):855-869.
19
Glass CK. Natoli G. Molecular control of activation and priming in macrophages[J]. Nat Immunol, 2016, 17(1):26-33.
20
O'Shea JJ,Murray PJ. Cytokine signaling modules in inflammatory responses[J]. Immunity, 2008, 28(4):477-487.
21
Luu K,Greenhill CJ,Majoros A, et al. STAT1 plays a role in TLR signal transduction and inflammatory responses[J]. Immunol Cell Biol, 2014, 92(9):761-769.
22
Gause WC,Wynn T,Allen JE. Type 2 immunity and wound healing:evolutionary refinement of adaptive immunity by helminths[J]. Nat Rev Immunol, 2013, 13(8):607-614.
23
Locksley RM. Asthma and allergic inflammation[J]. Cell, 2010, 140(6):777-783.
24
Gordon S. Martinez FO. Alternative activation of macrophages: mechanism and functions[J]. Immunity, 2010, 32(5):593-604.
25
Vannella KM,Wynn TA. Mechanisms of organ injury and repair by macrophages[J]. Annu Rev Physiol, 2017, 79: 593-617.
26
Stramer BM,Mori R,Martin P. The inflammation-fibrosis Link? A Jekyll and Hyde role for blood cells during wound repair[J]. J Invest Dermatol, 2007, 127(5):1009-1017.
27
Godwin JW,Pinto AR,Rosenthal NA. Macrophages are required for adult salamander limb regeneration[J]. Proc Natl Acad Sci U S A, 2013, 110(23):9415-9420.
28
Garza-Garcia AA,Driscoll PC,Brockes JP. Evidence for the local evolution of mechanisms underlying limb regeneration in salamanders[J]. Integr Comp Biol, 2010, 50(4):528-535.
29
Kumar A,Gates PB,Czarkwiani A, et al. An orphan gene is necessary for preaxial digit formation during salamander limb development[J]. Nat Commun, 2015, 6:8684.
30
Mounier R,Theret M,Arnold L, et al. AMPK alpha 1 Regulates Macrophage Skewing at the Time of Resolution of Inflammation during Skeletal Muscle Regeneration[J]. Cell Metab, 2013, 18(2):251-264.
31
Henson PM. Cell Removal: Efferocytosis[J]. Annu Rev Cell Dev Biol, 2017, 33:127-144.
32
Nagata S. Apoptosis and Clearance of Apoptotic Cells[J]. Annu Rev Immunol, 2018, 36: 489-517.
33
Nakaya M,Tanaka M,Okabe Y, et al. Opposite effects of rho family GTPases on engulfment of apoptotic cells by macrophages[J]. J Biol Chem, 2006, 281(13):8836-8842.
34
Henson PM,Bratton DL. Antiinflammatory effects of apoptotic cells[J]. J Clin Invest, 2013, 123(7):2773-2774.
35
Petrie TA,Strand NS,Yang CT, et al. Macrophages modulate adult zebrafish tail fin regeneration[J]. Development, 2014, 141(13):2581-2591.
36
Bosurgi L, Cao YG, Cabeza-Cabrerizo M, et al. Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells[J]. Science, 2017, 356(6342):1072-1076.
37
Feng MY,Marjon KD,Zhu FA, et al. Programmed cell removal by calreticulin in tissue homeostasis and cancer[J]. Nat Commun, 2018, 9(1):3194.
38
Heredia JE,Mukundan L,Chen FM, et al. Type 2 innate signals stimulate fibro/adipogenic progenitors to facilitate muscle regeneration[J]. Cell, 2013, 153(2):376-388.
39
Brenner D,Blaser H,Mak TW. Regulation of tumour necrosis factor signalling:live or let die[J]. Nat Rev Immunol, 2015, 15(6):362-374.
40
Hochreiter-Hufford A. Ravichandran KS. Clearing the dead:apoptotic cell sensing,recognition,engulfment,and digestion[J]. Cold Spring Harb Perspect Biol, 2013, 5(1):a008748.
41
Smith TD,Nagalla RR,Chen EY, et al. Harnessing macrophage plasticity for tissue regeneration[J]. Adv Drug Deliv Rev, 2017, 114:193-205.
42
Horckmans M,Ring L,Duchene J, et al. Neutrophils orchestrate post-myocardial infarction healing by polarizing macrophages towards a reparative phenotype[J]. Eur Heart J, 2017, 38(3):187-197.
43
Coakley RJ,Taggart C,Mcelvaney NG, et al. Cytosolic pH and the inflammatory microenvironment modulate cell death in human neutrophils after phagocytosis[J]. Blood, 2002, 100(9):3383-3391.
44
Serhan CN,Savill J. Resolution of inflammation: the beginning programs the end[J]. Nat Immunol, 2005, 6(12):1191-1197.
[1] 张凯, 乔永杰, 林志强, 刘健, 邓泽群, 谭飞, 曾健康, 李嘉欢, 李培杰, 周胜虎. 假体周围骨溶解中巨噬细胞极化的机制研究进展[J/OL]. 中华关节外科杂志(电子版), 2024, 18(05): 618-625.
[2] 杨瑾, 刘雪克, 张媛媛, 金钧, 韦瑶. 肠道微生物来源石胆酸对脓毒症相关肝损伤的保护作用[J/OL]. 中华危重症医学杂志(电子版), 2024, 17(04): 265-274.
[3] 钟雅雯, 王煜, 王海臻, 黄莉萍. 肌苷通过抑制线粒体通透性转换孔开放缓解缺氧/复氧诱导的人绒毛膜滋养层细胞凋亡[J/OL]. 中华妇幼临床医学杂志(电子版), 2024, 20(05): 525-533.
[4] 孙鸿坤, 艾虹, 陈正. 内质网应激介导的牙周炎骨改建失衡的研究进展[J/OL]. 中华口腔医学研究杂志(电子版), 2024, 18(04): 211-218.
[5] 唐亦骁, 陈峻, 连正星, 胡海涛, 鲁迪, 徐骁, 卫强. 白果内酯对小鼠肝缺血再灌注损伤保护作用研究[J/OL]. 中华移植杂志(电子版), 2024, 18(05): 278-282.
[6] 胡思平, 熊性宇, 徐航, 杨璐. 衰老相关分泌表型因子在前列腺癌发生发展中的作用机制[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(05): 425-434.
[7] 郑俊, 吴杰英, 谭海波, 郑安全, 李腾成. EGFR-MEK-TZ三联合分子的构建及其对去势抵抗性前列腺癌细胞增殖与凋亡的影响[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(05): 503-508.
[8] 李勇, 彭天明, 王倩倩, 陈育纯, 蒲小勇, 刘久敏. 基于失巢凋亡相关基因的膀胱癌预后模型构建及分析[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(04): 331-339.
[9] 黄程鑫, 陈莉, 刘伊楚, 王水良, 赖晓凤. OPA1 在乳腺癌组织的表达特征及在ER阳性乳腺癌细胞中的生物学功能研究[J/OL]. 中华细胞与干细胞杂志(电子版), 2024, 14(05): 275-284.
[10] 季加翠, 孙春斌, 罗恩丽. 姜黄素通过调节NF-κB/NLRP3通路减轻LPS诱导小胶质细胞神经炎症损伤[J/OL]. 中华细胞与干细胞杂志(电子版), 2024, 14(04): 193-203.
[11] 朱军, 宋家伟, 乔一桓, 郭雅婕, 刘帅, 姜玉, 李纪鹏. M2型巨噬细胞特征基因与结肠癌免疫微环境研究[J/OL]. 中华结直肠疾病电子杂志, 2024, 13(04): 303-311.
[12] 杜霞, 马梦青, 曹长春. 造影剂诱导的急性肾损伤的发病机制及干预靶点研究进展[J/OL]. 中华肾病研究电子杂志, 2024, 13(05): 279-282.
[13] 王国强, 张纲, 唐建坡, 张玉国, 杨永江. LINC00839 调节miR-17-5p/WEE1 轴对结直肠癌细胞增殖、凋亡和迁移的影响[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(06): 491-499.
[14] 靳英, 付小霞, 陈美茹, 袁璐, 郝力瑶. CD147调控MAPK信号通路对结肠癌细胞增殖和凋亡的影响及机制研究[J/OL]. 中华临床医师杂志(电子版), 2024, 18(05): 474-480.
[15] 刘霖, 张文欢, 宋雅茹, 姜云璐. Apelin-13 在阿尔茨海默病中的神经保护作用机制研究进展[J/OL]. 中华诊断学电子杂志, 2024, 12(04): 276-280.
阅读次数
全文


摘要


AI


AI小编
你好!我是《中华医学电子期刊资源库》AI小编,有什么可以帮您的吗?