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中华细胞与干细胞杂志(电子版) ›› 2018, Vol. 08 ›› Issue (04) : 248 -251. doi: 10.3877/cma.j.issn.2095-1221.2018.04.011

所属专题: 文献

综述

凋亡细胞的清除及组织稳态维持的研究进展
叶庆元1, 刘世宇2, 金岩2,()   
  1. 1. 710032 西安,军事口腔医学国家重点实验 口腔疾病国家临床医学研究中心 陕西省口腔疾病国际联合研究中心 第四军医大学口腔医院组织病理学教研室;710032 西安,第四军医大学基础医学院六大队
    2. 710032 西安,军事口腔医学国家重点实验 口腔疾病国家临床医学研究中心 陕西省口腔疾病国际联合研究中心 第四军医大学口腔医院组织病理学教研室
  • 收稿日期:2018-04-25 出版日期:2018-08-01
  • 通信作者: 金岩
  • 基金资助:
    国家自然科学基金资助(31670995)

Research progress in clearance of apoptotic cells and maintenance of tissue homeostasis

Qingyuan Ye1, Shiyu Liu2, Yan Jin2,()   

  1. 1. State Key Laboratory of Military Stomatology &National Clinical Research Center for Oral Diseases & Shanxi Key Laboratory of Oral Diseases, Department of Oral Histology and Pathology, School of Stomatology, the Fourth Military Medical University, Xi'an 710032, China; Sixth Student Brigade, College of Basic Medicine, the Fourth Military Medical University, Xi'an 710032, China
    2. State Key Laboratory of Military Stomatology &National Clinical Research Center for Oral Diseases & Shanxi Key Laboratory of Oral Diseases, Department of Oral Histology and Pathology, School of Stomatology, the Fourth Military Medical University, Xi'an 710032, China
  • Received:2018-04-25 Published:2018-08-01
  • Corresponding author: Yan Jin
  • About author:
    Corresponding Author: Jin Yan, Email:
引用本文:

叶庆元, 刘世宇, 金岩. 凋亡细胞的清除及组织稳态维持的研究进展[J]. 中华细胞与干细胞杂志(电子版), 2018, 08(04): 248-251.

Qingyuan Ye, Shiyu Liu, Yan Jin. Research progress in clearance of apoptotic cells and maintenance of tissue homeostasis[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2018, 08(04): 248-251.

机体在组织器官受到损伤时,细胞凋亡和机体对凋亡细胞的清除在组织再生中有着密不可分的联系,其背后促进受损组织器官再生的机制一直是研究热点所在。近期研究发现,巨噬细胞在清除凋亡细胞,维持机体稳态以及促进组织器官修复再生中起到了重要作用。本文主要从凋亡的信号通路、巨噬细胞的极化特点以及凋亡细胞与巨噬细胞的相互作用这3个方面对近期研究进行综述。

When tissues and organs are suffering from damage, the apoptosis of damaged cells along with the clearance of such debris has contributed a lot to tissue regeneration. The underlying mechanism of how apoptotic debris promotes regeneration of damaged tissues and organs has always been a research hotspot. Recent studies have showed that macrophages play an important role in clearing apoptotic cells, maintaining homeostasis, and promoting tissue regeneration. This review summarizes recent studies from three aspects: the apoptotic signaling pathway, the polarization characteristics of macrophages, and the interaction between apoptotic cells and macrophages.

1
Reed JC. Apoptosis-based therapies[J]. Nat Rev Drug Discov, 2002, 1(2):111-121.
2
Jacobson MD,Weil M,Raff MC. Programmed cell death in animal development[J]. Cell, 1997, 88(3):347-354.
3
Bartneck M,Fech V,Ehling J, et al. Histidine-Rich glycoprotein promotes macrophage activation and inflammation in chronic liver disease[J]. Hepatology, 2016, 63(4):1310-1324.
4
Murray PJ. Macrophage Polarization[J]. Annu Rev Physiol, 2017, 79: 541-566.
5
Wang X. The expanding role of mitochondria in apoptosis[J]. Genes Dev, 2001, 15(22):2922-2933.
6
Hsu YT,Wolter KG,Youle RJ. Cytosol-to-membrane redistribution of Bax and Bcl-X(L)during apoptosis[J]. Proc Natl Acad Sci U S A, 1997, 94(8):3668-3672.
7
Wolter KG,Hsu YT,Smith CL, et al. Movement of Bax from the cytosol to mitochondria during apoptosis[J]. J Cell Biol, 1997, 139(5):1281-1292.
8
Wang C. Youle RJ. The role of mitochondria in apoptosis[J]. Annu Rev Genet, 2009, 43: 95-118.
9
Ashkenazi A,Dixit VM. Death receptors:signaling and modulation[J]. Science, 1998, 281(5381):1305-1308.
10
Oshimi Y,Oda S,Honda Y, et al. Involvement of Fas ligand and Fas-mediated pathway in the cytotoxicity of human natural killer cells[J]. J Immunol, 1996, 157(7):2909-2915.
11
Peter ME,Krammer PH. The CD95(APO-1/Fas)DISC and beyond[J]. Cell Death Differ, 2003, 10(1):26-35.
12
Nagata S. Fas ligand-induced apoptosis[J]. Annu Rev Genet, 1999, 33: 29-55.
13
Li H,Zhu H,Xu CJ, et al. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis[J]. Cell, 1998, 94(4):491-501.
14
Banjerdpongchai R,Kongtawelert P,Khantamat O, et al. Mitochondrial and endoplasmic reticulum stress pathways cooperate in zearalenone-induced apoptosis of human leukemic cells[J]. J Hematol Oncol, 2010, 3:50.
15
Logue SE,Cleary P,Saveljeva S, et al. New directions in ER stress-induced cell death[J]. Apoptosis, 2013, 18(5):537-546.
16
Van Furth R,Cohn ZA,Hirsch JG, et al. The mononuclear phagocyte system:a new classification of macrophages,monocytes,and their precursor cells[J]. Bull World Health Organ, 1972, 46(6):845-852.
17
Ginhoux F,Guilliams M. Tissue-Resident macrophage ontogeny and homeostasis[J]. Immunity, 2016, 44(3):439-449.
18
Goubau D,Deddouche S,Reis e Sousa C. Cytosolic sensing of viruses[J]. Immunity, 2013, 38(5):855-869.
19
Glass CK. Natoli G. Molecular control of activation and priming in macrophages[J]. Nat Immunol, 2016, 17(1):26-33.
20
O'Shea JJ,Murray PJ. Cytokine signaling modules in inflammatory responses[J]. Immunity, 2008, 28(4):477-487.
21
Luu K,Greenhill CJ,Majoros A, et al. STAT1 plays a role in TLR signal transduction and inflammatory responses[J]. Immunol Cell Biol, 2014, 92(9):761-769.
22
Gause WC,Wynn T,Allen JE. Type 2 immunity and wound healing:evolutionary refinement of adaptive immunity by helminths[J]. Nat Rev Immunol, 2013, 13(8):607-614.
23
Locksley RM. Asthma and allergic inflammation[J]. Cell, 2010, 140(6):777-783.
24
Gordon S. Martinez FO. Alternative activation of macrophages: mechanism and functions[J]. Immunity, 2010, 32(5):593-604.
25
Vannella KM,Wynn TA. Mechanisms of organ injury and repair by macrophages[J]. Annu Rev Physiol, 2017, 79: 593-617.
26
Stramer BM,Mori R,Martin P. The inflammation-fibrosis Link? A Jekyll and Hyde role for blood cells during wound repair[J]. J Invest Dermatol, 2007, 127(5):1009-1017.
27
Godwin JW,Pinto AR,Rosenthal NA. Macrophages are required for adult salamander limb regeneration[J]. Proc Natl Acad Sci U S A, 2013, 110(23):9415-9420.
28
Garza-Garcia AA,Driscoll PC,Brockes JP. Evidence for the local evolution of mechanisms underlying limb regeneration in salamanders[J]. Integr Comp Biol, 2010, 50(4):528-535.
29
Kumar A,Gates PB,Czarkwiani A, et al. An orphan gene is necessary for preaxial digit formation during salamander limb development[J]. Nat Commun, 2015, 6:8684.
30
Mounier R,Theret M,Arnold L, et al. AMPK alpha 1 Regulates Macrophage Skewing at the Time of Resolution of Inflammation during Skeletal Muscle Regeneration[J]. Cell Metab, 2013, 18(2):251-264.
31
Henson PM. Cell Removal: Efferocytosis[J]. Annu Rev Cell Dev Biol, 2017, 33:127-144.
32
Nagata S. Apoptosis and Clearance of Apoptotic Cells[J]. Annu Rev Immunol, 2018, 36: 489-517.
33
Nakaya M,Tanaka M,Okabe Y, et al. Opposite effects of rho family GTPases on engulfment of apoptotic cells by macrophages[J]. J Biol Chem, 2006, 281(13):8836-8842.
34
Henson PM,Bratton DL. Antiinflammatory effects of apoptotic cells[J]. J Clin Invest, 2013, 123(7):2773-2774.
35
Petrie TA,Strand NS,Yang CT, et al. Macrophages modulate adult zebrafish tail fin regeneration[J]. Development, 2014, 141(13):2581-2591.
36
Bosurgi L, Cao YG, Cabeza-Cabrerizo M, et al. Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells[J]. Science, 2017, 356(6342):1072-1076.
37
Feng MY,Marjon KD,Zhu FA, et al. Programmed cell removal by calreticulin in tissue homeostasis and cancer[J]. Nat Commun, 2018, 9(1):3194.
38
Heredia JE,Mukundan L,Chen FM, et al. Type 2 innate signals stimulate fibro/adipogenic progenitors to facilitate muscle regeneration[J]. Cell, 2013, 153(2):376-388.
39
Brenner D,Blaser H,Mak TW. Regulation of tumour necrosis factor signalling:live or let die[J]. Nat Rev Immunol, 2015, 15(6):362-374.
40
Hochreiter-Hufford A. Ravichandran KS. Clearing the dead:apoptotic cell sensing,recognition,engulfment,and digestion[J]. Cold Spring Harb Perspect Biol, 2013, 5(1):a008748.
41
Smith TD,Nagalla RR,Chen EY, et al. Harnessing macrophage plasticity for tissue regeneration[J]. Adv Drug Deliv Rev, 2017, 114:193-205.
42
Horckmans M,Ring L,Duchene J, et al. Neutrophils orchestrate post-myocardial infarction healing by polarizing macrophages towards a reparative phenotype[J]. Eur Heart J, 2017, 38(3):187-197.
43
Coakley RJ,Taggart C,Mcelvaney NG, et al. Cytosolic pH and the inflammatory microenvironment modulate cell death in human neutrophils after phagocytosis[J]. Blood, 2002, 100(9):3383-3391.
44
Serhan CN,Savill J. Resolution of inflammation: the beginning programs the end[J]. Nat Immunol, 2005, 6(12):1191-1197.
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