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中华细胞与干细胞杂志(电子版) ›› 2026, Vol. 16 ›› Issue (03) : 162 -169. doi: 10.3877/cma.j.issn.2095-1221.2026.03.004

综述

LCN2在脓毒症中的作用机制研究进展
刘国臣1,3, 安嘉伟1,3, 朱俊宇1, 代伟宏2, 李芬2,()   
  1. 1400042 重庆,陆军军医大学大坪医院战伤感染与特需药品研究室 创伤与化学中毒全国重点实验室
    2573100 海口,海南医科大学第二附属医院急诊科 海南省急危重症临床医学研究中心
    3400038 重庆,陆军军医大学基础医学院
  • 收稿日期:2025-08-06 出版日期:2026-06-01
  • 通信作者: 李芬
  • 基金资助:
    海南省卫生健康科技创新联合项目(WSJK2025MS141)

Advances in the mechanisms of lipocalin-2 in sepsis

Guochen Liu1,3, Jiawei An1,3, Junyu Zhu1, Weihong Dai2, Fen Li2,()   

  1. 1Department of Wound Infection and Drug, Daping Hospital, Army Medical University, State Key Laboratory of Trauma and Chemical Poisoning, Chongqing 400042, China
    2Emergency Department, the Second Affiliated Hospital of Hainan Medical University, Hainan Provincial Clinical Research Center for Critical Care Medicine, Haikou 573100, China
    3Basic Medical College, Army Medical University, Chongqing 400038, China
  • Received:2025-08-06 Published:2026-06-01
  • Corresponding author: Fen Li
引用本文:

刘国臣, 安嘉伟, 朱俊宇, 代伟宏, 李芬. LCN2在脓毒症中的作用机制研究进展[J/OL]. 中华细胞与干细胞杂志(电子版), 2026, 16(03): 162-169.

Guochen Liu, Jiawei An, Junyu Zhu, Weihong Dai, Fen Li. Advances in the mechanisms of lipocalin-2 in sepsis[J/OL]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2026, 16(03): 162-169.

脂质运载蛋白2 (LCN2)又称中性粒细胞明胶酶相关脂质运载蛋白(NGAL),作为一种重要的先天免疫蛋白,在脓毒症的发病机制中发挥关键作用。近年研究表明,LCN2通过调控铁代谢、炎症反应、氧化应激及抗菌免疫等多重机制影响脓毒症的发生发展,其表达水平与患者病情严重程度及预后密切相关,提示其作为潜在生物标志物及治疗靶点的应用价值。LCN2在脓毒症相关的多脏器损伤中也显示出重要作用,包括急性肾损伤、肠损伤、脑病、肝损伤、心肌损伤和肺损伤。未来研究需进一步探究其具体作用机制及临床应用潜力,以期为脓毒症的早期干预与治疗提供新思路。

Lipocalin 2 (LCN2) , also known as neutrophil gelatinase-associated lipocalin (NGAL) , is an essential innate immune protein that critically contributes to the pathogenesis of sepsis. Recent studies show that LCN2 affects sepsis onset and progression through multiple mechanisms, including the regulation of iron metabolism, inflammatory response, oxidative stress, and antibacterial immune response. The expression level of LCN2 was correlated with disease severity and patient prognosis, indicating its application value as a potential biomarker and therapeutic target. LCN2 also plays a significant role in sepsis-associated multi-organ injury, encompassing acute kidney injury, intestinal damage, encephalopathy, hepatic injury, myocardial damage, and lung injury. Future investigations should further elucidate its precise mechanisms and clinical utility to offer novel strategies for the early intervention and therapy of sepsis.

图1 LCN2的分子结构
图2 LCN2与脓毒症相关的多器官功能障碍注:LCN2为脂质运载蛋白2;LPS/CLP为脂多糖或盲肠结扎穿刺术炎症/脓毒症模型;PTGS2 (COX-2)为环氧化酶- 2基因;GPX4为谷胱甘肽过氧化物酶4;SLC7A11为溶质载体家族7成员11;ROS为活性氧;TLR4-NF-κB为Toll样受体4-核因子κB
图3 LCN2的作用机制注:LCN2为脂质运载蛋白2;Tf为转蛋白铁;SOD/SPSx为超氧化物歧化酶/谷胱甘肽过氧化物酶基因
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