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中华细胞与干细胞杂志(电子版) ›› 2026, Vol. 16 ›› Issue (03) : 150 -161. doi: 10.3877/cma.j.issn.2095-1221.2026.03.003

论著

诱导多能干细胞在血管再生领域的全球研究趋势可视化分析
王辉, 张含宇, 胡乐凡, 孟文卓, 王飞, 郭建明, 郭连瑞, 谷涌泉()   
  1. 100053 北京,首都医科大学宣武医院血管外科
  • 收稿日期:2025-08-19 出版日期:2026-06-01
  • 通信作者: 谷涌泉
  • 基金资助:
    国家重点研发项目(2021YFC2500500); 首都医科大学2025年教育教学改革研究课题(2025JYY101)

Visualized analysis of global research trends on induced pluripotent stem cells in vascular regeneration

Hui Wang, Hanyu Zhang, Lefan Hu, Wenzhuo Meng, Fei Wang, Jianming Guo, Lianrui Guo, Yongquan Gu()   

  1. Department of Vascular Surgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
  • Received:2025-08-19 Published:2026-06-01
  • Corresponding author: Yongquan Gu
引用本文:

王辉, 张含宇, 胡乐凡, 孟文卓, 王飞, 郭建明, 郭连瑞, 谷涌泉. 诱导多能干细胞在血管再生领域的全球研究趋势可视化分析[J/OL]. 中华细胞与干细胞杂志(电子版), 2026, 16(03): 150-161.

Hui Wang, Hanyu Zhang, Lefan Hu, Wenzhuo Meng, Fei Wang, Jianming Guo, Lianrui Guo, Yongquan Gu. Visualized analysis of global research trends on induced pluripotent stem cells in vascular regeneration[J/OL]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2026, 16(03): 150-161.

目的

诱导多能干细胞(iPSCs)因具备无限增殖与多向分化潜能,在血管研究中具有广阔的应用前景。本文旨在通过文献计量学方法系统分析iPSCs在血管研究领域的全球发展趋势、研究热点及未来方向。

方法

基于Web of Science核心合集数据库,检索并收集iPSCs与血管相关的研究文献。采用Bibliometrix、VOSviewer和CiteSpace等工具,对年度发文量、国家与机构合作网络、关键词聚类与突现分析、文献共被引网络等进行可视化与定量分析。

结果

iPSCs在血管研究中的发文量持续增长,美国和中国在该领域处于领先地位,并形成跨国合作网络。研究热点逐渐从基础分化与机制探索转向血管再生、疾病建模及转化医学应用。关键词突现分析揭示,血管内皮细胞分化、血管再生医学及个体化治疗是当前和未来的研究重点。

结论

iPSCs血管研究领域正快速发展,体现出显著的国际合作与多学科交叉特征。未来研究应更多关注临床转化,结合多组学技术和智能分析方法,以推动iPSCs在血管替代与新型治疗策略中的应用。

Objective

Induced pluripotent stem cells (iPSCs) , with their unlimited proliferative capacity and multi-lineage differentiation potential, hold great promise in vascular research. This study aimed to systematically analyze the global trends, research hotspots, and future directions of iPSC-related vascular research using bibliometric methods.

Methods

Publications on iPSCs and vascular research were retrieved from the Web of Science Core Collection. Bibliometric and visualization analyses were conducted using Bibliometrix, VOSviewer, and CiteSpace, focusing on annual publication trends, country and institutional collaboration networks, keyword clustering and burst detection, as well as co-citation analysis.

Results

The number of publications on iPSCs in vascular research has steadily increased. The United States and China lead this field and have established extensive international collaboration networks. Research hotspots have shifted from basic differentiation mechanisms to vascular regeneration, disease modeling, and translational applications. Keyword burst analysis highlighted endothelial differentiation, vascular regenerative medicine, and personalized therapy as emerging focal points.

Conclusion

Research on iPSCs in the vascular field is rapidly expanding, characterized by strong international collaboration and interdisciplinary integration. Future studies should emphasize clinical translation by integrating multi-omics and intelligent analytical approaches, thereby advancing the application of iPSCs in vascular graft development and novel therapeutic strategies.

图1 诱导多能干细胞血管研究相关文献筛选与计量学分析流程
图2 iPSCs在血管研究领域的全球发表趋势与研究贡献
图3 iPSCs血管研究中的期刊分布、影响力及来源分析
图4 iPSCs血管研究领域核心作者学术影响力、发文量及引用特征分析注:Articles:文章数量;TC:总被引次数;TCpY:年均被引次数
图5 iPSCs血管研究领域合作网络与机构—国家分布特征注:SCP%:单国合作比例;MCP%:多国合作比例
表1 WoSCC中高频关键词及其中心性
表2 WoSCC中关键词聚类分析明细
聚类编号 数量 轮廓系数 年份 高频术语(对数似然比,显著性水平)
0 119 0.669 2019 blood-brain barrier (228.53, 1.0E-4); alzheimers disease (49.03, 1.0E-4); brain microvascular endothelial cells (48.69, 1.0E-4); in vitro model (41.54, 1.0E-4); permeability (36.2, 1.0E-4)
1 110 0.667 2013 endothelial progenitor cell (66.64, 1.0E-4); cell therapy (58.05, 1.0E-4); mesenchymal stem cells (52.22, 1.0E-4); regenerative medicine (47.44, 1.0E-4); stem cells (43.93, 1.0E-4)
2 87 0.647 2016 extracellular vesicles (41.49, 1.0E-4); angiogenesis (31.19, 1.0E-4); therapy (19.82, 1.0E-4); exosomes (19.69, 1.0E-4); growth (17.55, 1.0E-4)
3 83 0.683 2014 induced pluripotent stem cells (54.05, 1.0E-4); gene (33.64, 1.0E-4); mice (25.72, 1.0E-4); cell (25.62, 1.0E-4); disease (24.02, 1.0E-4)
4 75 0.708 2016 tissue engineering (69.17, 1.0E-4); 3d bioprinting (28.49, 1.0E-4); cardiomyocyte (27.07, 1.0E-4); cardiac tissue engineering (25.89, 1.0E-4); engineered heart tissue (25.89, 1.0E-4)
5 72 0.742 2011 differentiation (50.52, 1.0E-4); endothelial cell (45.85, 1.0E-4); induction (36.68, 1.0E-4); pluripotent stem cell (33.9, 1.0E-4); generation (32.72, 1.0E-4)
6 59 0.708 2014 hemogenic endothelium (30.27, 1.0E-4); human embryonic stem cells (26.67, 1.0E-4); hematopoietic stem cells (26.67, 1.0E-4); aortic endothelium (22.84, 1.0E-4); developmental biology (22.84, 1.0E-4)
7 48 0.795 2016 age-related macular degeneration (15.66, 1.0E-4); hydrogel (13.93, 0.001); blood-brain barrier (12.38, 0.001); induced pluripotent stem cells (12.13, 0.001); integration (11.56, 0.001)
表3 前25个引用突增强度最高的关键词
图6 iPSCs血管研究中的高被引文献、本地参考文献及期刊双图叠加
图7 iPSCs血管研究的全球合作模式
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