全胰腺切除联合自体胰岛细胞团移植多中心项目（POST）研究进展

doi:10.3877/cma.j.issn.2095-1221.2025.04.007

全胰腺切除联合自体胰岛细胞团移植（TPIAT）是治疗药物和内镜治疗失败的成人和儿童衰弱性慢性胰腺炎（CP）和复发性急性胰腺炎（RAP）的首选治疗方式。该方式在欧美等国家已开展近50年。2014年Bellin教授发起一项TPIAT多中心前瞻性观察研究（POST），拟对TPIAT患者选择、疼痛持续和风险、糖尿病风险、手术最佳时机、如何进行干预和手术成本效益等问题进行系统研究，并持续发表一系列研究报告。本综述介绍POST项目的相关背景和项目已发表的相关研究成果，并围绕这些研究方向对其他团队研究的结果也进行总结，旨在增进我国医务人员对TPIAT技术和POST研究相关进展的了解，为我国临床TPIAT工作的开展提供参考。

关键词: 全胰腺切除, 自体胰岛移植, 慢性胰腺炎, 复发性急性胰腺炎, 前瞻性研究

Total pancreatectomy with islet autotransplantation (TPIAT) is the preferred treatment for debilitating chronic pancreatitis (CP) and recurrent acute pancreatitis (RAP) in adults and children who have failed pharmacological and endoscopic therapies. This approach has been practiced in Europe and the United States for nearly 50 years. In 2014, Professor Bellin initiated a large-scale multicenter prospective observational study (POST) on TPIAT to systematically investigate the key questions regarding the patient selection, risks of persistent pain and disability, diabetes risk, optimal timing for surgery, intervention strategies, and the economic viability of the procedure, publishing a series of research works. This review outlines the background of the POST and its published research findings, and also reviewed the results of other teams' research surrounding these directions, aiming to enhance healthcare professionals' understanding of TPIAT technology and its advancements, thereby provide reference for the development of clinical TPIAT work in China.

Key words: Total pancreatectomy, Islet autotransplantation, Chronic pancreatitis, Recurrent acute pancreatitis, Prospective study

表1 多中心前瞻性观察研究项目（POST）的研究目的^[9]

序号	研究方案中规定的目的
1	（1a）确定与TPIAT术后良好的疼痛和健康相关的生活质量结局相关的患者情况和疾病特征；（1b）TPIAT干预的最佳时机，以解决疼痛并改善生活质量；（1c）在部分患者中，中枢敏化对缓解疼痛的影响。
2	（2a）确定与IAT术后良好的血糖结果相关的患者情况和疾病特征；（2b）TPIAT手术后能获得胰岛素脱离的最佳手术时机。
3	确定TPIAT的成本效益。

表1 多中心前瞻性观察研究项目（POST）的研究目的^[9]

序号	研究方案中规定的目的
1	（1a）确定与TPIAT术后良好的疼痛和健康相关的生活质量结局相关的患者情况和疾病特征；（1b）TPIAT干预的最佳时机，以解决疼痛并改善生活质量；（1c）在部分患者中，中枢敏化对缓解疼痛的影响。
2	（2a）确定与IAT术后良好的血糖结果相关的患者情况和疾病特征；（2b）TPIAT手术后能获得胰岛素脱离的最佳手术时机。
3	确定TPIAT的成本效益。

1	Desai CS. Total pancreatectomy with islet cell auto-transplantation for chronic pancreatitis: sustaining long-term glycemic health with or without graft function[J]. Hepatobiliary Surg Nutr, 2024, 13(6):1068-1070.
2	Bashir A, Joseph N, Hammond JS, et al. Evaluating continuous glucose monitoring after total pancreatectomy with or without islet autotransplantation: a scoping systematic review[J]. Pancreas, 2025, 54(3):e268-e277.
3	Barthold L, Smith KD, Chaidarun SS, et al. Quality of life following total pancreatectomy with islet autotransplantation: a patient experience survey[J]. Pancreas, 2024, 53(8):e652-e656.
4	Wei J, Ou Y, Chen J, et al. Mapping global new-onset, worsening, and resolution of diabetes following partial pancreatectomy: a systematic review and meta-analysis[J]. Int J Surg, 2024, 110(3):1770-1780.
5	Yamane K, Anazawa T, Nagai K, et al. Current status of total pancreatectomy with islet autotransplantation for chronic and recurrent acute pancreatitis[J]. Ann Gastroenterol Surg, 2024, 8(3):401-412.
6	Takita M, Lara LF, Naziruddin B, et al. Effect of the duration of chronic pancreatitis on pancreas islet yield and metabolic outcome following islet autotransplantation[J]. J Gastrointest Surg, 2015, 19(7):1236-1246.
7	Zureikat AH, Nguyen T, Boone BA, et al. Robotic total pancreatectomy with or without autologous islet cell transplantation: replication of an open technique through a minimal access approach[J]. Surg Endosc, 2015, 29(1):176-183.
8	Gumbs AA, Daskalaki D, Milone L. Laparoscopic total pancreatectomy for chronic pancreatitis[J]. Surg Laparosc Endosc Percutan Tech, 2018, 28(2):e62. doi: 10.1097/SLE.0000000000000519.
9	Bellin MD, Abu-El-Haija M, Morgan K, et al. A multicenter study of total pancreatectomy with islet autotransplantation (TPIAT): POST (Prospective Observational Study of TPIAT)[J]. Pancreatology, 2018, 18(3):286-290.
10	Kirchner VA, Dunn TB, Beilman GJ, et al. Total pancreatectomy with islet autotransplantation for acute recurrent and chronic pancreatitis[J]. Curr Treat Options Gastroenterol, 2017, 15(4):548-561.
11	Heinzman C, Hornung L, Lin TK, et al. Total pancreatectomy with islet autotransplantation reduces opioid use and improves nutritional support in children with debilitating pancreatitis[J]. PLoS One, 2023, 18(8):e0289620. doi: 10.1371/journal.pone.0289620.
12	Sutherland DE, Radosevich DM, Bellin MD, et al. Total pancreatectomy and islet autotransplantation for chronic pancreatitis[J]. J Am Coll Surg, 2012, 214(4):409-424; discussion 424-426.
13	Chinnakotla S, Beilman GJ, Dunn TB, et al. Factors predicting outcomes after a total pancreatectomy and islet autotransplantation lessons learned from over 500 cases[J]. Ann Surg, 2015, 262(4):610-622.
14	Chinnakotla S, Bellin MD, Schwarzenberg SJ, et al. Total pancreatectomy and islet autotransplantation in children for chronic pancreatitis: indication, surgical techniques, postoperative management, and long-term outcomes[J]. Ann Surg, 2014, 260(1):56-64.
15	Bellin MD, Beilman GJ, Sutherland DE, et al. How durable is total pancreatectomy and intraportal islet cell transplantation for treatment of chronic pancreatitis?[J]. J Am Coll Surg, 2019, 228(4):329-339.
16	LaBarre NT, Morgan KA, Adams DB, et al. The impact of endoscopic retrograde cholangiopancreatography on islet cell yield during total pancreatectomy with islet autotransplantation[J]. Pancreas, 2019, 48(1):77-79.
17	Trikudanathan G, Elmunzer BJ, Yang Y, et al. Preoperative ERCP has no impact on islet yield following total pancreatectomy and islet autotransplantation (TPIAT): results from the prospective observational study of TPIAT (POST) cohort[J]. Pancreatology, 2021, 21(1):275-281.
18	Berger MG, Majumder K, Hodges JS, et al. Microbial contamination of transplant solutions during pancreatic islet autotransplants is not associated with clinical infection in a pediatric population[J]. Pancreatology, 2016, 16(4):555-562.
19	Abu-El-Haija M, Anazawa T, Beilman GJ, et al. The role of total pancreatectomy with islet autotransplantation in the treatment of chronic pancreatitis: A report from the International Consensus Guidelines in chronic pancreatitis[J]. Pancreatology, 2020, 20(4):762-771.
20	Vasu S, Kumano K, Darden CM, et al. MicroRNA signatures asfuture biomarkers for diagnosis of diabetes states[J]. Cells, 2019, 8(12):1533. doi: 10.3390/cells8121533.
21	Vasu S, Yang JM, Hodges J, et al. Circulating miRNA in patients undergoing total pancreatectomy and islet autotransplantation[J]. Cell Transplant, 2021, (30):1-11.
22	Vasu S, Saracino G, Darden CM, et al. Clinical and biological significance of circulating miRNAs in chronic pancreatitis patients undergoing total pancreatectomy with islet autotransplantation[J]. Clin Transl Med, 2023, 13(10):e1434. doi: 10.1002/ctm2.1434.
23	Bellin MD, Forlenza GP, Majumder K, et al. Total pancreatectomy with islet autotransplantation resolves pain in young children with severe chronic pancreatitis[J]. J Pediatr Gastroenterol Nutr, 2017, 64(3):440-445.
24	Kotagal M, Slusher J, Ahmad S, et al. In-hospital and 90-day outcomes after total pancreatectomy with islet autotransplantation for pediatric chronic and acute recurrent pancreatitis[J]. Am J Transplant, 2019, 19(4):1187-1194.
25	Johnson PR, White SA, Robertson GS, et al. Pancreatic islet autotransplantation combined with total pancreatectomy for the treatment of chronic pancreatitis--the Leicester experience[J]. J Mol Med (Berl), 1999, 77(1):130-132.
26	Grützmann R, Ludwig B, Weitz J, et al. Total pancreatectomy and islet autotransplantation in a child with recurrent pancreatitis[J]. Zentralbl Chir, 2016, 141(1):17-20.
27	Kumar S, Ooi CY, Werlin S, et al. Risk factors associated with pediatric acute recurrent and chronic pancreatitis:lessons from INSPPIRE[J]. JAMA Pediatr, 2016, 170(6):562-569.
28	Schwarzenberg SJ, Bellin M, Husain SZ, et al. Pediatric chronic pancreatitis is associated with genetic risk factors and substantial disease burden[J]. J Pediatr, 2015, 166(4):890-896.e891.
29	Schwarzenberg SJ, Uc A, Zimmerman B, et al. Chronic pancreatitis: pediatric and adult cohorts show similarities in disease progress despite different risk factors[J]. J Pediatr Gastroenterol Nutr, 2019, 68(4):566-573.
30	Loganathan G, Subhashree V, Narayanan S, et al. Improved recovery of human islets from young donor pancreases utilizing increased protease dose to collagenase for digesting peri-islet extracellular matrix[J]. Am J Transplant, 2019, 19(3):831-843.
31	Wilhelm JJ, Balamurugan AN, Bellin MD, et al. Progress in individualizing autologous islet isolation techniques for pediatric islet autotransplantation after total pancreatectomy in children for chronic pancreatitis[J]. Am J Transplant, 2021, 21(2):776-786.
32	Nathan JD, Yang Y, Eaton A, et al. Surgical approach and short-term outcomes in adults and children undergoing total pancreatectomy with islet autotransplantation: a report from the prospective observational study of TPIAT[J]. Pancreatology, 2022, 22(1):1-8.
33	Fan CJ, Hirose K, Walsh CM, et al. Laparoscopic total pancreatectomy with islet autotransplantation and intraoperative islet separation as a treatment for patients with chronic pancreatitis[J]. JAMA Surg, 2017, 152(6):550-556.
34	Kinny-Köster B, Walsh CM, Sun Z, et al. Minimally invasive total pancreatectomy with islet autotransplantation for chronic pancreatitis: the robotic approach[J]. Surg Endosc, 2024, 38(7):3948-3956.
35	Balamurugan AN, Elder DA, Abu-El-Haija M, et al. Islet cell transplantation in children[J]. Semin Pediatr Surg, 2020, 29(3):150925. doi: 10.1016/j.sempedsurg.2020.150925.
36	Gurria JP, Mullapudi B, Lowe CMO, et al. Intraoperative pyloric botulinum toxin injection for post total pancreatectomy with islet autotransplantation gastroparesis improvement in children[J]. J Pediatr Surg, 2025, 60(7):162341. doi: 10.1016/j.jpedsurg.2025.162341.
37	Brennan PL, Schutte KK, Moos RH. Pain and use of alcohol to manage pain: prevalence and 3-year outcomes among older problem and non- problem drinkers[J]. Addiction, 2005, 100(6):777-786.
38	Gureje O, Von Korff M, Kola L, et al. The relation between multiple pains and mental disorders: results from the world mental health surveys[J]. Pain, 2008, 135(1-2):82-91.
39	Hales CM, Martin CB, Gu Q. Prevalence of prescription pain medication use among adults: united states, 2015-2018[J]. NCHS Data Brief, 2020, (369):1-8.
40	Zale EL, Maisto SA, Ditre JW. Anxiety and depression in bidirectional relations between pain and smoking: implications for smoking cessation[J]. Behav Modif, 2016, 40(1-2):7-28.
41	Machicado JD, Amann ST, Anderson MA, et al. Quality of life in chronic pancreatitis is determined by constant pain, disability/unemployment, current smoking, and associated co-morbidities[J]. Am J Gastroenterol, 2017, 112(4):633-642.
42	Tjora E, Dimcevski G, Haas SL, et al. Patient reported exposure to smoking and alcohol abuse are associated with pain and other complications in patients with chronic pancreatitis[J]. Pancreatology, 2020, 20(5):844-851.
43	O'Brien T, Christrup LL, Drewes AM, et al. European pain federation position paper on appropriate opioid use in chronic pain management[J]. Eur J Pain, 2017, 21(1):3-19.
44	Drossman D, Szigethy E. The narcotic bowel syndrome: a recent update[J]. Am J Gastroenterol Suppl, 2014, 2(1):22-30.
45	Højsted J, Sjøgren P. Addiction to opioids in chronic pain patients: a literature review[J]. Eur J Pain, 2007, 11(5):490-518.
46	Irving HM, Samokhvalov AV, Rehm J. Alcohol as a risk factor for pancreatitis. A systematic review and meta-analysis[J]. Jop, 2009, 10(4):387-392.
47	Singh VK, Yadav D, Garg PK. Diagnosis and management of chronic pancreatitis: a review[J]. Jama, 2019, 322(24):2422-2434.
48	Ditre JW, Brandon TH, Zale EL, et al. Pain, nicotine, and smoking: research findings and mechanistic considerations[J]. Psychol Bull, 2011, 137(6):1065-1093.
49	Ditre JW, Zale EL, LaRowe LR. A reciprocal model of pain and substance use: transdiagnostic considerations, clinical implications, and future directions[J]. Annu Rev Clin Psychol, 2019, 15:503-528.
50	Fluharty M, Taylor AE, Grabski M, et al. The association of cigarette smoking with depression and anxiety: a systematic review[J]. Nicotine Tob Res, 2017, 19(1):3-13.
51	Hooten MW, Shi Y, Gazelka HM, et al. The effects of depression and smoking on pain severity and opioid use in patients with chronic pain[J]. Pain, 2011, 152(1):223-229.
52	Lara LF, Wastvedt S, Hodges JS, et al. The association of smoking and alcohol abuse on anxiety and depression in patients with recurrent acute or chronic pancreatitis undergoing total pancreatectomy and islet autotransplantation: a report from the prospective observational study of TPIAT cohort[J]. Pancreas, 2021, 50(6):852-858.
53	Wang TW, Asman K, Gentzke AS, et al. Tobacco product use among adults-united states, 2017[J]. MMWR Morb Mortal Wkly Rep, 2018, 67(44):1225-1232.
54	Center for disease control and prevention. smoking and tobacco use[EB/OL]. (2024-09-17)[2025-08-04]. URL
55	Center for disease control and prevention. alcohol use and your health[EB/OL]. (2025-01-14)[2025-08-04]. URL
56	Taylor G, McNeill A, Girling A, et al. Change in mental health after smoking cessation: systematic review and meta-analysis[J]. Bmj, 2014, 348:g1151. doi: 10.1136/bmj.g1151.
57	Han S, Kheder J, Bocelli L, et al. Smoking cessation in a chronic pancreatitis population[J]. Pancreas, 2016, 45(9):1303-1308.
58	Walsh RM, Saavedra JR, Lentz G, et al. Improved quality of life following total pancreatectomy and auto-islet transplantation for chronic pancreatitis[J]. J Gastrointest Surg, 2012, 16(8):1469-1477.
59	Morgan KA, Lancaster WP, Owczarski SM, et al. Patient selection for total pancreatectomy with islet autotransplantation in the surgical management of chronic pancreatitis[J]. J Am Coll Surg, 2018, 226(4):446-451.
60	McEachron KR, Downs EM, Schwarzenberg SJ, et al. Fat-soluble vitamin deficiency is common in children with chronic pancreatitis undergoing total pancreatectomy with islet autotransplantation[J]. J Pediatr Gastroenterol Nutr, 2021, 72(1):123-126.
61	Duggan SN, Smyth ND, O'Sullivan M, et al. The prevalence of malnutrition and fat-soluble vitamin deficiencies in chronic pancreatitis[J]. Nutr Clin Pract, 2014, 29(3):348-354.
62	Forrest KY, Stuhldreher WL. Prevalence and correlates of vitamin D deficiency in US adults[J]. Nutr Res, 2011, 31(1):48-54.
63	Dutta SK, Bustin MP, Russell RM, et al. Deficiency of fat-soluble vitamins in treated patients with pancreatic insufficiency[J]. Ann Intern Med, 1982, 97(4):549-552.
64	Sikkens EC, Cahen DL, Koch AD, et al. The prevalence of fat-soluble vitamin deficiencies and a decreased bone mass in patients with chronic pancreatitis[J]. Pancreatology, 2013, 13(3):238-242.
65	Zarshenas N, Tapsell LC, Batterham M, et al. Investigating the prevalence of nutritional abnormalities in patients prior to and following bariatric surgery[J]. Nutr Diet, 2022, 79(5):590-601.
66	Araújo MM, Mendes MM, Lanham-New SA, et al. Frequency of vitamin D deficiency and associated factors in long-term bariatric surgery patients: a cross-sectional study[J]. Obes Surg, 2022, 32(7):2386-2396.
67	Downs EM, Eaton A, Witkowski P, et al. Nutritional risks in patients undergoing total pancreatectomy islet auto transplantation in the POST consortium[J]. J Gastrointest Surg, 2023, 27(9):1893-1902.
68	Radigan AE. Post-Gastrectomy: managing the nutrition fall-out[J]. Pract Gastroenterol, 2004, 28(6):63-75.
69	Hasse JM, Meng S, Silpe S, et al. Nutrition challenges following total pancreatectomy with islet autotransplantation[J]. Nutr Clin Pract, 2024, 39(1):86-99.
70	Bellin MD, Ramanathan K, Chinnakotla S. Total pancreatectomy with islet auto-transplantation: surgical procedure, outcomes, and quality of life[J]. Adv Surg, 2023, 57(1):15-30.
71	McEachron KR, Bellin MD. Total pancreatectomy and islet autotransplantion for chronic and recurrent acute pancreatitis[J]. Curr Opin Gastroenterol, 2018, 34(5):367-373.
72	Kobayashi T, Manivel JC, Bellin MD, et al. Correlation of pancreatic histopathologic findings and islet yield in children with chronic pancreatitis undergoing total pancreatectomy and islet autotransplantation[J]. Pancreas, 2010, 39(1):57-63.
73	Verma N, Rajab A, Buss J, et al. Immediate postoperative insulin requirements may predict metabolic outcome after total pancreatectomy and islet autotransplantation[J]. J Diabetes Res, 2020, 2020:9282310. doi: 10.1155/2020/9282310.
74	Mattke J, Eaton A, Wijkstrom M, et al. Islet isolation outcomes in patients undergoing total pancreatectomy with islet autotransplantation in the POST consortium[J]. Transplantation, 2025, 109(1):207-216.
75	Ricordi C. Quantitative and qualitative standards for islet isolation assessment in humans and large mammals[J]. Pancreas, 1991, 6(2):242-244.
76	Wilhelm JJ, Bellin MD, Dunn TB, et al. Proposed thresholds for pancreatic tissue volume for safe intraportal islet autotransplantation after total pancreatectomy[J]. Am J Transplant, 2013, 13(12):3183-3191.
77	Suszynski TM, Wilhelm JJ, Radosevich DM, et al. Islet size index as a predictor of outcomes in clinical islet autotransplantation[J]. Transplantation, 2014, 97(12):1286-1291.
78	Darden CM, Mohammed ARH, Kirkland J, et al. Total pancreatectomy with islet autotransplantation outcomes in patients with pancreatitis of genetic etiology: a single-center experience with a large cohort of patients[J]. J Gastrointest Surg, 2024, 28(8):1309-1318.
79	Trinh KV, Smith KD, Gardner TB. Patient and procedural factors associated with increased islet cell yield in total pancreatectomy with islet autotransplantation[J]. Pancreas, 2018, 47(8):985-989.
80	Young MC, Theis JR, Hodges JS, et al. Preoperative computerized tomography and magnetic resonance imaging of the pancreas predicts pancreatic mass and functional outcomes after total pancreatectomy and islet autotransplant[J]. Pancreas, 2016, 45(7):961-966.
81	Darden C, Kumano K, Liu Y, et al. Diffuse calcification of pancreas impairs endocrine function and predicts poor outcome in total pancreatectomy with islet autotransplantation[J]. Am J Transplant, 2023, 23(11):1781-1792.
82	Trout AT, Nolan HR, Abu-El-Haija M, et al. Imaging prediction of islet yield and post-operative insulin requirement in children undergoing total pancreatectomy with islet autotransplantation[J]. Pancreatology, 2021, 21(1):269-274.
83	Lad SU, Ali KF, Johnston PC, et al. Follow-up of patients after total pancreatectomy and islet cell autotransplantation at off-site islet isolation facility[J]. J Clin Endocrinol Metab, 2023, 108(6):1425-1431.
84	Kizilgul M, Wilhelm JJ, Beilman GJ, et al. Effect of intrapancreatic fat on diabetes outcomes after total pancreatectomy with islet autotransplantation[J]. J Diabetes, 2018, 10(4):286-295.
85	姚豫桐，罗兰云，薛华, 等. 我国首例胰腺次全切除联合自体胰岛细胞移植治疗慢性胰腺炎临床分析[J]. 中国普外基础与临床杂志, 2013, 20(10):1155-1158.
86	胡晨璐，裴香茹，王芳, 等. 1例胰腺癌行全胰切除联合自体胰岛移植患者的护理[J]. 中华护理杂志, 2025, 60(7):880-883.
87	李兆申. 慢性胰腺炎临床研究的挑战与展望[J]. 中国实用内科杂志, 2024, 44(7):529-531.

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Progress of total pancreatectomy with islet autotransplantation: a multicenter prospective observational study (POST)

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Progress of total pancreatectomy with islet autotransplantation: a multicenter prospective observational study (POST)