| 1 |
Businello G, Angerilli V, Parente P, et al. Molecular landscapes of gastric pre-neoplastic and pre-invasive lesions[J]. Int J Mol Sci, 2021, 22(18):9950.
|
| 2 |
Singh S, Bhat MY, Sathe G, et al. Proteomic signatures of diffuse and intestinal subtypes of gastric cancer[J]. Cancers (Basel). 2021, 13(23):5930.
|
| 3 |
Hirata A, Utikal J, Yamashita S, et al. Dose-dependent roles for canonical Wnt signalling in de novo crypt formation and cell cycle properties of the colonic epithelium[J]. Development, 2013, 140(1):66-75.
|
| 4 |
Acar A, Hidalgo-Sastre A, Leverentz MK, et al. Inhibition of Wnt signalling by Notch via two distinct mechanisms[J]. Sci Rep, 2021, 11(1):9096.
|
| 5 |
Sundaram MV. The love-hate relationship between Ras and Notch[J]. Genes Dev, 2005, 19(16):1825-1839.
|
| 6 |
Pond KW, Morris JM, Alkhimenok O, et al. Live-cell imaging in human colonic monolayers reveals ERK waves limit the stem cell compartment to maintain epithelial homeostasis[J]. Elife, 2022,11:e78837.
|
| 7 |
Kabiri Z, Greicius G, Zaribafzadeh H, et al. Wnt signaling suppresses MAPK-driven proliferation of intestinal stem cells[J]. J Clin Invest, 2018, 128(9):3806-3812.
|
| 8 |
Kotani T, Ihara N, Okamoto S, et al. Role of Ras in regulation of intestinal epithelial cell homeostasis and crosstalk with Wnt signaling[J]. PLoS One, 2021, 16(8):e0256774.
|
| 9 |
Zhan T, Ambrosi G, Wandmacher AM, et al. MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer[J]. Nat Commun, 2019, 10(1):2197.
|
| 10 |
Qi Z, Li Y, Zhao B, et al. BMP restricts stemness of intestinal Lgr5+ stem cells by directly suppressing their signature genes[J]. Nat Commun, 2017, 8:13824.
|
| 11 |
Hoffmann W. Self-renewal and cancers of the gastric epithelium: an update and the role of the lectin TFF1 as an antral tumor suppressor[J]. Int J Mol Sci, 2022, 23(10):5377.
|
| 12 |
Chang W,Wang H, Kim W, et al. Hormonal suppression of stem cells inhibits symmetric cell division and gastric tumorigenesis[J]. Cell Stem Cell, 2020, 26(5):739-754.
|
| 13 |
Flanagan DJ, Austin CR, Vincan E, et al. Wnt signalling in gastrointestinal epithelial stem cells[J]. Genes (Basel), 2018, 9(4):178.
|
| 14 |
Blassberg R, Patel H, Watson T, et al. Sox2 levels regulate the chromatin occupancy of WNT mediators in epiblast progenitors responsible for vertebrate body formation[J]. Nat Cell Biol, 2022, 24(5):633-644.
|
| 15 |
Ye L, Lou F, Yu F, et al. NUMB maintains bone mass by promoting degradation of PTEN and GLI1 via ubiquitination in osteoblasts[J]. Bone Res, 2018, 10(6):32.
|
| 16 |
Aguirre A, Rubio ME, Gallo V. Notch and EGFR pathway interaction regulates neural stem cell number and self-renewal[J]. Nature, 2010, 467(7313):323-327.
|
| 17 |
Ortega-Campos SM, García-Heredia JM. The multitasker protein: a look at the multiple capabilities of NUMB[J]. Cells, 2023, 12(2):333.
|
| 18 |
Kaur N, Lum MA, Lewis RE, et al. A novel antiproliferative PKCα-Ras-ERK signaling axis in intestinal epithelial cells[J]. J Biol Chem, 2022, 298(7):102121.
|
| 19 |
Duckworth CA. Identifying key regulators of the intestinal stem cell niche[J]. Biochem Soc Trans, 2021, 49(5):2163-2176.
|
| 20 |
Takahashi T, Shiraishi A. Stem cell signaling pathways in the small intestine[J]. Int. J. Mol. Sci, 2020, 21(6):2032.
|
| 21 |
Demitrack ES, Gifford GB, Keeley TM, et al. Notch signaling regulates gastric antral LGR5 stem cell function[J]. EMBO J, 2015, 34(20):2522-2536.
|
| 22 |
Syu LJ, Zhao X, Zhang Y, et al. Invasive mouse gastric adenocarcinomas arising from Lgr5+ stem cells are dependent on crosstalk between the Hedgehog/GLI2 and mTOR pathways[J]. Oncotarget, 2016,7(9):10255-10270.
|
| 23 |
刘先勇,王建宁. Hedgehog与胃腺体分化及Correa级联学说关系的研究进展[J].中国细胞生物学学报, 2015, 37(11):1572-1580.
|
| 24 |
McCarthy N, Manieri E, Storm EE, et al. Distinct mesenchymal cell populations generate the essential intestinal BMP signaling gradient[J]. Cell Stem Cell, 2020, 26(3):391-402.
|
| 25 |
Zinke J, Schneider FT, Harter PN, et al. β-Catenin-Gli1 interaction regulates proliferation and tumor growth in medulloblastoma[J]. Mol Cancer, 2015,14(1):17.
|
| 26 |
Li Y, Hibbs MA, Gard AL, et al. Genome-wide analysis of N1ICD/RBPJ targets in vivo reveals direct transcriptional regulation of Wnt, SHH, and hippo pathway effectors by Notch1[J]. Stem Cells, 2012, 30(4):741-752.
|
| 27 |
Xia R, Xu M, Yang J, et al. The role of Hedgehog and Notch signaling pathway in cancer. Mol Biomed, 2022, 3(1):44.
|
| 28 |
Yabut O, Pleasure S J,Yoon K. A Notch above Sonic Hedgehog[J]. Developmental Cell, 2015, 33(4):371-372.
|
| 29 |
Zhang J, Fan J, Zeng X, et al. Hedgehog signaling in gastrointestinal carcinogenesis and the gastrointestinal tumor microenvironment[J].Acta Pharm Sin B, 2021, 11(3):609-620.
|
| 30 |
Wall DS , Mears AJ , Mcneill B , et al. Progenitor cell proliferation in the retina is dependent on notch-independent sonic Hedgehog/Hes1 activity[J]. J Cell Biol, 2009, 184(1):101-112.
|
| 31 |
Das HK, Hontiveros SS. Inhibition of p-mTOR represses transcription of PS1 and Notch 1-signaling[J]. Front Biosci (Landmark Ed), 2020, 25(6):1172-1183.
|
| 32 |
Hibdon ES, Razumilava N, Keeley TM, et al. Notch and mTOR signaling pathways promote human gastric cancer cell proliferation[J]. Neoplasia, 2019, 21(7):702-712.
|
| 33 |
Vivien Koh, Jayati Chakrabarti, Meaghan Torvund, et al. Hedgehog transcriptional effector GLI mediates mTOR-Induced PD-L1 expression in gastric cancer organoids[J]. Cancer Lett, 2021, 518: 59-71.
|
| 34 |
Larsen LJ, Møller LB. Crosstalk of Hedgehog and mTORC1 pathways[J]. Cells, 2020, 9(10):2316.
|
| 35 |
Li K, Wu H, Wang A, et al. mTOR signaling regulates gastric epithelial progenitor homeostasis and gastric tumorigenesis via MEK1-ERKs and BMP-Smad1 pathways[J]. Cell reports, 2021, 35(5):109069.
|
| 36 |
Pantazi E, Gemenetzidis E, Teh MT, et al. GLI2 is a regulator of β-catenin and is associated with loss of E-Cadherin, cell invasiveness, and long-term epidermal regeneration[J]. J Invest Dermatol, 2017, 137(8):1719-1730.
|
| 37 |
Pelullo M, Zema S, Nardozza F, et al. Wnt, notch, and TGF-β pathways impinge on hedgehog signaling complexity: an open window on cancer[J]. Front Genet, 2019, 10:711.
|
| 38 |
Carballo GB, Honorato JR, de Lopes GPF, et al. A highlight on Sonic hedgehog pathway[J]. Cell Commun Signal, 2018, 16(1):11.
|
| 39 |
Suchors C, Kim J. Canonical Hedgehog pathway and noncanonical GLI transcription factor activation in cancer[J]. Cells, 2022, 11(16):2523.
|
| 40 |
Nguyen NM, Cho J. Hedgehog Pathway inhibitors as targeted cancer therapy and strategies to overcome drug resistance[J]. Int J Mol Sci, 2022, 23(3):1733.
|
| 41 |
Pietrobono S, Gagliardi S, Stecca B. Non-canonical Hedgehog signaling pathway in cancer: activation of GLI transcription factors beyond smoothened[J]. Front Genet, 2019, 10:556.
|
| 42 |
Yang J, Wang J, Zhang Y, et al. c-Jun phosphorylated by JNK is required for protecting Gli2 from proteasomal-ubiquitin degradation by PGE2-JNK signaling axis[J]. Biochim Biophys Acta Mol Cell Res, 2023, 1870(3):119418.
|
| 43 |
Stecca B, Mas C, Clement V, et al. Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways[J]. Proc Natl Acad Sci U S A, 2007, 104(14): 5895-5900.
|
| 44 |
Tang Y, Yang G, Zhang J, et al. E-cadherin is required for the homeostasis of Lgr5+ gastric antral stem cells[J]. Int J Biol Sci, 2019, 15(1):34-43.
|
| 45 |
Li XB, Yang G, Zhu L, et al. Gastric Lgr5(+) stem cells are the cellular origin of invasive intestinal-type gastric cancer in mice[J].Cell Res, 2016, 26(7):838-849.
|
| 46 |
García-Heredia JM, Carnero A. NUMB and NUMBL differences in gene regulation[J]. Oncotarget, 2018, 9(10):9219-9234.
|
| 47 |
Beck SE, Carethers JM. BMP suppresses PTEN expression via RAS/ERK signaling[J]. Cancer Biol Ther, 2007, 6(8):1313-1317.
|
| 48 |
Chow JY, Quach KT, Cabrera BL, et al. RAS/ERK modulates TGFbeta-regulated PTEN expression in human pancreatic adenocarcinoma cells[J]. Carcinogenesis, 2007, 28(11):2321-2327.
|
| 49 |
Fedorova O, Parfenyev S, Daks A, et al. The Role of PTEN in epithelial-mesenchymal transition[J]. Cancers (Basel), 2022, 14(15):3786.
|
| 50 |
Koveitypour Z, Panahi F, Vakilian M, et al. Signaling pathways involved in colorectal cancer progression[J]. Cell Biosci, 2019, 9:97.
|
| 51 |
Han J, Lin K, Zhang X, et al. PTEN-mediated AKT/β-catenin signaling enhances the proliferation and expansion of Lgr5+ hepatocytes[J]. Int J Biol Sci, 2021, 17(3):861-868.
|
| 52 |
Eritja N, Felip I, Dosil MA, et al. A Smad3-PTEN regulatory loop controls proliferation and apoptotic responses to TGF-β in mouse endometrium[J]. Cell Death Differ, 2017, 24(8):1443-1458.
|
| 53 |
Lee MS, Jeong MH, Lee HW, et al. Author Correction: PI3K/AKT activation induces PTEN ubiquitination and destabilization accelerating tumourigenesis[J]. Nat Commun, 2020, 11(1):6236.
|
| 54 |
Vidotto T, Melo CM, Lautert-Dutra W, et al. Pan-cancer genomic analysis shows hemizygous PTEN loss tumors are associated with immune evasion and poor outcome[J]. Sci Rep, 2023, 13(1):5049.
|
| 55 |
Song L, Li ZY , Liu WP , et al. Crosstalk between Wnt/β-catenin and Hedgehog/Gli signaling pathways in colon cancer and implications for therapy[J]. Cancer Biol Ther, 2015, 16(1):1-7.
|
| 56 |
Sabol M, Trnski D, Musani V, et al. Role of GLI transcription factors in pathogenesis and their potential as new therapeutic targets[J]. Int J Mol Sci, 2018, 19(9):2562.
|
| 57 |
Fan L, Jin P, Qian Y, et al. Case report: prenatal diagnosis of postaxial polydactyly with bi-allelic variants in smoothened (SMO)[J]. Front Genet, 2022, 13:887082.
|
| 58 |
Maiti S, Mondal S, Satyavarapu EM, et al. mTORC2 regulates hedgehog pathway activity by promoting stability to Gli2 protein and its nuclear translocation[J]. Cell Death Dis, 2017, 8(7):e2926.
|
| 59 |
Angius A, Scanu AM, Arru C, et al. Portrait of cancer stem cells on colorectal cancer: molecular biomarkers, signaling pathways and miRNAome[J]. Int J Mol Sci, 2021, 22(4):1603.
|
| 60 |
Loh HY, Norman BP, Lai KS, et al. Post-transcriptional regulatory crosstalk between micrornas and canonical TGF-β/BMP signalling cascades on osteoblast lineage: a comprehensive review[J]. Int J Mol Sci, 2023, 24(7):6423.
|
| 61 |
Yao Y, Zhang Z, Kong F, et al. Smad4 induces cell death in HO-8910 and SKOV3 ovarian carcinoma cell lines via PI3K-mTOR involvement[J]. Exp Biol Med (Maywood), 2020, 245(9):777-784.
|
| 62 |
Puri P, Grimmett G, Faraj R, et al. Elevated protein kinase a activity in stomach mesenchyme disrupts mesenchymal-epithelial crosstalk and induces preneoplasia[J]. Cell Mol Gastroenterol Hepatol, 2022, 14(3):643-668.
|
| 63 |
Luo K. Signaling Cross Talk between TGF-β/Smad and other signaling pathways[J]. Cold Spring Harb Perspect Biol, 2017, 9(1):a022137.
|
| 64 |
Perumal E, So Youn K, Sun S, et al. PTEN inactivation induces epithelial-mesenchymal transition and metastasis by intranuclear translocation of β-catenin and snail/slug in non-small cell lung carcinoma cells[J]. Lung Cancer, 2019, 130:25-34.
|
| 65 |
Kostouros A, Koliarakis I, Natsis K, et al. Large intestine embryogenesis: molecular pathways and related disorders (Review) [J]. Int J Mol Med, 2020, 46(1):27-57.
|
| 66 |
Chhabra S, Liu L, Goh R, et al. Dissecting the dynamics of signaling events in the BMP, WNT, and NODAL cascade during self-organized fate patterning in human gastruloids[J]. PLoS Biol, 2019, 17(10):e3000498.
|
| 67 |
Perekatt AO, Shah PP, Cheung S, et al. SMAD4 suppresses WNT-driven dedifferentiation and oncogenesis in the differentiated gut epithelium[J]. Cancer Res, 2018, 78(17):4878-4890.
|
| 68 |
Wizenty J, Tacke F, Sigal M. Responses of gastric epithelial stem cells and their niche to Helicobacter pylori infection[J]. Ann Transl Med, 2020, 8(8):568.
|
| 69 |
Ye W, Takabayashi H, Yang Y, et al. Regulation of gastric Lgr5+ve cell homeostasis by bone morphogenetic protein (BMP) signaling and inflammatory stimuli[J]. Cell Mol Gastroenterol Hepatol, 2018, 5(4):523-538.
|
| 70 |
Hayakawa Y, Ariyama H, Stancikova J, et al. Mist1 expressing gastric stem cells maintain the normal and neoplastic gastric epithelium and are supported by a perivascular stem cell niche[J]. Cancer Cell, 2015, 28(6):800-814.
|
| 71 |
Wizenty J, Müllerke S, Kolesnichenko M, et al.Gastric stem cells promote inflammation and gland remodeling in response to Helicobacter pylori via Rspo3-Lgr4 axis[J]. EMBO J, 2022, 41(13):e109996.
|
| 72 |
Chung WC, Zhou Y, Atfi A, et al. Downregulation of notch signaling in kras-induced gastric metaplasia[J]. Neoplasia, 2019, 21(8):810-821.
|
| 73 |
De Vas MG, Kopp JL, Heliot C, et al. Hnf1b controls pancreas morphogenesis and the generation of Ngn3+ endocrine progenitors[J]. Development, 2015, 142(5):871-882
|
| 74 |
Gere-Becker MB, Pommerenke C, Lingner T, et al. Retinoic acid-induced expression of Hnf1b and Fzd4 is required for pancreas development in Xenopus laevis[J]. Development. 2018, 145(12): dev161372.
|
| 75 |
Jiang M, Azevedo-Pouly AC, Deering TG, et al. MIST1 and PTF1 collaborate in feed-forward regulatory loops that maintain the pancreatic acinar phenotype in adult mice[J]. Mol Cell Biol, 2016, 36(23):2945-2955.
|
| 76 |
Duque M, Amorim JP, Bessa J. Ptf1a function and transcriptional cis-regulation, a cornerstone in vertebrate pancreas development[J]. FEBS J, 2022, 289(17):5121-5136.
|
| 77 |
Xie X, Zhou Z, Song Y, et al. Mist1 inhibits epithelial-mesenchymal transition in gastric adenocarcinoma via downregulating the Wnt/β-catenin Pathway[J]. J Cance, 2021, 12(15):4574-4584.
|
| 78 |
Trejo-Solis C, Escamilla-Ramirez A, Jimenez-Farfan D, et al. Crosstalk of the Wnt/β-catenin signaling pathway in the induction of apoptosis on cancer cells[J]. Pharmaceuticals (Basel), 2021,14(9):871.
|
| 79 |
Ghazvini M, Sonneveld P, Kremer A, et al. Cancer stemness in Apc- vs. Apc/KRAS-driven intestinal tumorigenesis[J]. PLoS One, 2013, 8(9):e73872.
|
| 80 |
SuJ, Morgani SM, David CJ, et al. TGF-β orchestrates fibrogenic and developmental EMTs via the RAS effector RREB1[J]. Nature, 2020, 577(7791):566-571.
|
| 81 |
Pak KH, Kim DH, Kim H, et al. Differences in TGF-β1 signaling and clinicopathologic characteristics of histologic subtypes of gastric cancer[J]. BMC Cancer, 2016,16:60.
|
| 82 |
Xu P, Lin X, Feng XH. Posttranslational regulation of smads[J]. Cold Spring Harb Perspect Biol, 2016, 8(12):a022087.
|
| 83 |
Tago K, Ohta S, Funakoshi-Tago M, et al. STAT3 and ERK pathways are involved in cell growth stimulation of the ST2/IL1RL1 promoter[J]. FEBS Open Bio, 2017,7(2):293-302.
|
| 84 |
Hu X, Li J, Fu M, et al. The JAK/STAT signaling pathway: from bench to clinic[J]. Signal Transduct Target Ther, 2021,6(1):402.
|
| 85 |
Jeong WJ , Ro EJ , Choi KY. Interaction between Wnt/β-catenin and RAS-ERK pathways and an anti-cancer strategy via degradations of β-catenin and RAS by targeting the Wnt/β-catenin pathway[J]. NPJ Precis Oncol, 2018, 2(1):5.
|
| 86 |
Ternet C, Kiel C. Signaling pathways in intestinal homeostasis and colorectal cancer: KRAS at centre stage[J]. Cell Commun Signal, 2021, 19(1):31.
|
| 87 |
Zhan T, Ambrosi G, Wandmacher AM, et al. MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer[J]. Nat Commun, 2019, 10(1):2197.
|
| 88 |
Sheng W, Malagola E, Nienhüser H, et al. Hypergastrinemia expands gastric ECL cells through CCK2R+ progenitor cells via ERK activation[J]. Cell Mol Gastroenterol Hepatol, 2020, 10(2):434-449.
|
| 89 |
Li Z, Zhang YY, Zhang H, et al. Asymmetric cell division and tumor heterogeneity[J]. Front Cell Dev Biol, 2022,10:938685.
|
| 90 |
Wuputra K, Ku CC, Pan JB,et al. Stem cell biomarkers and tumorigenesis in gastric cancer[J]. J Pers Med, 2022, 12(6):929.
|
| 91 |
Ghatak D, Das Ghosh D, Roychoudhury S. Cancer stemness: p53 at the wheel[J]. Front Oncol, 2021, 10:604124.
|
| 92 |
Xiao Q, Werner J, Venkatachalam N, et al. Cross-Talk between p53 and Wnt signaling in cancer[J]. Biomolecules, 2022,12(3):453.
|
| 93 |
Li YH, Li YX, Li M, et al. The Ras-ERK1/2 signaling pathway regulates H3K9ac through PCAF to promote the development of pancreatic cancer[J]. Life Sci, 2020, 256:117936.
|
| 94 |
Kung CP, Weber JD. It's Getting complicated-a fresh look at p53-MDM2-ARF triangle in tumorigenesis and cancer therapy[J]. Front Cell Dev Biol, 2022, 10:818744.
|