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中华细胞与干细胞杂志(电子版)

中华细胞与干细胞杂志(电子版) ›› 2021, Vol. 11 ›› Issue (01) : 51 -56. doi: 10.3877/cma.j.issn.2095-1221.2021.01.008

所属专题： 文献；

综述

膝关节内干细胞/祖细胞在软骨再生中作用研究进展
杨振1, 李浩1, 付力伟1, 高仓健1, 赵天元1, 陈威1, 廖志垚1, 李品学1, 李旭2, 王福鑫2, 田广招1, 孙志强1, 查康康1, 曹福洋3, 周建2, 眭翔2, 刘舒云2, 郭全义1,†()   
  1. 1. 100853　北京，中国人民解放军总医院第一医学中心骨科研究所　骨科再生医学北京市重点实验室　全军骨科战创伤重点实验室；300071　天津，南开大学医学院
    2. 100853　北京，中国人民解放军总医院第一医学中心骨科研究所　骨科再生医学北京市重点实验室　全军骨科战创伤重点实验室
    3. 100853　北京，中国人民解放军总医院第一医学中心骨科研究所　骨科再生医学北京市重点实验室　全军骨科战创伤重点实验室；450052　郑州大学第一附属医院骨科
  • 收稿日期:2020-06-23 出版日期:2021-02-01
  • 通信作者: 郭全义
  • 基金资助:
    国家重点研发计划课题(2019YFA0110600); 国家自然科学基金(81772319)

Progress of native joint-resident stem cells/progenitor cells in cartilage regeneration

Zhen Yang1, Hao Li1, Liwei Fu1, Cangjian Gao1, Tianyuan Zhao1, Wei Chen1, Zhiyao Liao1, Pinxue Li1, Xu Li2, Fuxin Wang2, Guangzhao Tian1, Zhiqiang Sun1, Kangkang Zha1, Fuyang Cao3, Jian Zhou2, Xiang Sui2, Shuyun Liu2, Quanyi Guo1,†()   

  1. 1. Institute of Orthopedics, the First Medical Centre, Chinese PLA General Hospital; Beijing Key Lab of Regenerative Medicine in Orthopedics; Key Laboratory of Musculoskeletal Trauma & War Injuries PLA, Beijing 100853, China; School of Medicine, Nankai University, Tianjin 300071, China
    2. Institute of Orthopedics, the First Medical Centre, Chinese PLA General Hospital; Beijing Key Lab of Regenerative Medicine in Orthopedics; Key Laboratory of Musculoskeletal Trauma & War Injuries PLA, Beijing 100853, China
    3. Institute of Orthopedics, the First Medical Centre, Chinese PLA General Hospital; Beijing Key Lab of Regenerative Medicine in Orthopedics; Key Laboratory of Musculoskeletal Trauma & War Injuries PLA, Beijing 100853, China; Department of Orthopaedics, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
  • Received:2020-06-23 Published:2021-02-01
  • Corresponding author: Quanyi Guo
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杨振, 李浩, 付力伟, 高仓健, 赵天元, 陈威, 廖志垚, 李品学, 李旭, 王福鑫, 田广招, 孙志强, 查康康, 曹福洋, 周建, 眭翔, 刘舒云, 郭全义. 膝关节内干细胞/祖细胞在软骨再生中作用研究进展[J]. 中华细胞与干细胞杂志(电子版), 2021, 11(01): 51-56.

Zhen Yang, Hao Li, Liwei Fu, Cangjian Gao, Tianyuan Zhao, Wei Chen, Zhiyao Liao, Pinxue Li, Xu Li, Fuxin Wang, Guangzhao Tian, Zhiqiang Sun, Kangkang Zha, Fuyang Cao, Jian Zhou, Xiang Sui, Shuyun Liu, Quanyi Guo. Progress of native joint-resident stem cells/progenitor cells in cartilage regeneration[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2021, 11(01): 51-56.

关节软骨（AC）由于缺乏血管、神经和淋巴，一旦损伤无法自我修复。虽然以外源性细胞为基础的治疗策略在一定程度上能够再生关节软骨，但仍然存在手术间隔长、供体有限、细胞体外培养易去分化和病原体传播等风险。成人膝关节存在许多类型干细胞/祖细胞（SCPCs），当软骨损伤时，就会被动员，迁移到损伤部位，参与再生修复。因此，基于趋化内源性SCPCs到损伤部位的AC原位再生修复策略，充分利用机体自我修复潜力，同时避免了外源性细胞策略的缺点，已经成为研究的热点。本综述主要介绍膝关节内SCPCs类型、迁移路径以及其在软骨损伤修复中的作用。重点介绍内源性AC再生修复策略的研究现状，以期吸引更多的研究人员参与这一有前景的研究领域。

关键词: 膝关节, 软骨损伤, 干细胞, 祖细胞, 再生

Articular cartilage (AC) cannot repair itself due to the lack of blood vessels, nerves and lymph, To some extent, exogenous cell-based treatment strategies can regenerate articular cartilage, however, there were some risks such as long surgical interval, limited donor availability, easy cell dedifferentiation in vitro and pathogen transmission. When cartilage is damaged, many kinds of stem cells/progenitor cells (SCPCs) in adult knee joints will be mobilized and migrated to damaged area and participate in regeneration repair. Therefore, based on recruitment endogenous SCPCs, the in-situ AC regeneration strategy has become a research hotspot, which fully utilizes the body's self-repair potential and avoids the disadvantages of exogenous cell strategy. The characteristics and migration pathway of different SCPCs in the knee joint and its role in the repair of cartilage injury were introduced. At the same time, progress of endogenous AC regeneration and repair strategies were mainly focused, in order to attract more researchers to participate in this promising research field.

Key words: Knee joint, Cartilage injury, Stem cells, Progenitor cells, Regeneration
图1 干细胞/祖细胞潜在迁移路径
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