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中华细胞与干细胞杂志(电子版)

中华细胞与干细胞杂志(电子版) ›› 2020, Vol. 10 ›› Issue (06) : 359 -363. doi: 10.3877/cma.j.issn.2095-1221.2020.06.007

所属专题： 文献；

综述

毛囊干细胞的应用领域
伍婧玥1, 李敏2, 王刚2, 刁波2,†()   
  1. 1. 430065　武汉，武汉科技大学医学院
    2. 430070　武汉，中部战区总医院基础医学实验室；430070　武汉，中枢神经系统肿瘤发生与干预湖北省重点实验室
  • 收稿日期:2020-01-05 出版日期:2020-12-01
  • 通信作者: 刁波
  • 基金资助:
    湖北省卫生健康委员会面上项目(WJ2019M263)

Applications of hair follicle stem cells

Jingyue Wu1, Min Li2, Gang Wang2, Bo Diao2,†()   

  1. 1. Medical College of Wuhan University of Science and Technology, 430065 Wuhan, China
    2. Basic Medical Laboratory, General Hospital of Central Theater Command, 430070 Wuhan, China; Hubei Key Laboratory of Central Nervous System Tumor and Intervention, 430070 Wuhan, China
  • Received:2020-01-05 Published:2020-12-01
  • Corresponding author: Bo Diao
  • About author:
    Corresponding author:Diao Bo, Email:
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引用本文：

伍婧玥, 李敏, 王刚, 刁波. 毛囊干细胞的应用领域[J]. 中华细胞与干细胞杂志(电子版), 2020, 10(06): 359-363.

Jingyue Wu, Min Li, Gang Wang, Bo Diao. Applications of hair follicle stem cells[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2020, 10(06): 359-363.

毛囊干细胞是存在于毛囊外根鞘隆突部的一种成体干细胞，来源丰富且易于获取。与毛囊内的其他成体干细胞一样，毛囊干细胞具有许多的优点，如自我更新能力强、高增殖能力和多分化潜能等，这使得毛囊干细胞成为非常好的分离干细胞来源以及组织工程和再生医学应用的组织来源。毛囊干细胞在表皮和皮肤组织工程中的研究作为一个迅速发展的全新领域，目前已在基础和临床研究方面都取得了巨大进展。本文主要就毛囊干细胞的应用前景展开综述，包括干细胞诱导毛发新生，促进创面愈合，促进神经、脊髓修复，心肌细胞样细胞分化等。

关键词: 毛囊干细胞, 神经修复, 创面愈合, 脊髓损伤, 心肌样细胞

Hair follicle stem cells are a kind of adult stem cells which exist in the protuberance of root sheath outside hair follicles, which characterize in rich sources and easy access. Like other adult stem cells in hair follicles, hair follicle stem cells have many advantages, such as self-renewal, high proliferation ability and multi-differentiation potential, etc., resulting in that hair follicle stem cells become a very good source of isolated stem cells and a tissue source for tissue engineering and regenerative medicine applications. The researches on hair follicle stem cells in epidermis and skin tissue engineering are booming, calling for a comprehensive review. This paper mainly reviews the advances in the application of hair follicle stem cells, including the induction of hair regeneration by stem cells, the repair of damaged skin, the promotion of nerve and spinal cord repair and the differentiation of cardiac-like cells.

Key words: Hair follicle stem cells, Nerve repair, Wound healing, Spinal cord injury, Cardiac-like cells
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