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中华细胞与干细胞杂志(电子版) ›› 2020, Vol. 10 ›› Issue (05) : 297 -302. doi: 10.3877/cma.j.issn.2095-1221.2020.05.008

所属专题: 文献

综述

干细胞治疗心脏病的研究进展
邓海燕1, 刘馨2, 缪着1, 马波1,()   
  1. 1. 650500 昆明医科大学药学院暨云南省天然药物药理重点实验室;653100 玉溪,云南时光肌生物技术有限公司
    2. 653100 玉溪,云南时光肌生物技术有限公司;650033 昆明,云南省细胞工程中心有限公司
  • 收稿日期:2020-04-07 出版日期:2020-10-01
  • 通信作者: 马波

Research progress of stem cells in the treatment of heart diseases

Haiyan Deng1, Xin Liu2, Zhuo Miao1, Bo Ma1,()   

  1. 1. Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, China; Yunnan Reborn Biotech Co. LTD, Yuxi 653100, China
    2. Yunnan Reborn Biotech Co. LTD, Yuxi 653100, China; Yunnan Cell Engineering Center Co.Ltd, Kunming 650033, China
  • Received:2020-04-07 Published:2020-10-01
  • Corresponding author: Bo Ma
  • About author:
    Corresponding author: Ma Bo, Email:
引用本文:

邓海燕, 刘馨, 缪着, 马波. 干细胞治疗心脏病的研究进展[J]. 中华细胞与干细胞杂志(电子版), 2020, 10(05): 297-302.

Haiyan Deng, Xin Liu, Zhuo Miao, Bo Ma. Research progress of stem cells in the treatment of heart diseases[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2020, 10(05): 297-302.

心脏病患者的心脏组织发生病变,会对心脏功能造成不同程度的影响,成人的心肌细胞(CMs)再生能力差,无法进行自我修复,目前心脏病的治疗方法不能恢复已经损伤的心功能。经过长期的观察和研究,多种干细胞与外泌体均具有治疗作用。多种干细胞可以分化为心脏祖细胞(CPCs)或心肌样细胞,也可以分泌生物活性因子修复坏死心肌组织,改善受损的心功能。近年来,干细胞移植策略和治疗方案的改进提升了其在心脏病中的治疗效果。本文比较了不同类型干细胞在治疗心脏病上的应用,并介绍了干细胞移植的改进方法。

Heart tissue in patients with heart disease is diseased and has different degrees of impact on cardiac function. Adults have poor cardiomyocyte regeneration and therefore are unable to self-repair, nor can current heart disease treatments restore impaired cardiac function. After long-term observation and research, a variety of stem cells and exosomes have been proved to be effective in treating heart diseases. Various stem cells can differentiate into cardiac progenitor cells or cardiomyoid cells, and can also secrete bioactive factors to repair necrotic myocardial tissue and improve impaired cardiac function. Recently, improvements in stem cell transplantation strategies and treatment have improved therapeutic efficacy in heart disease. This paper compares the application of different stem cells in the treatment and introduces improved methods of stem cell transplantation.

表1 干细胞移植策略的比较
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