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中华细胞与干细胞杂志(电子版) ›› 2020, Vol. 10 ›› Issue (02) : 110 -114. doi: 10.3877/cma.j.issn.2095-1221.2020.02.007

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综述

长链非编码RNA在肝细胞肝癌发病中的作用及其机制研究进展
郑妮1, 夏伟1,()   
  1. 1. 200137 上海中医药大学附属第七人民医院核医学科
  • 收稿日期:2019-07-24 出版日期:2020-04-01
  • 通信作者: 夏伟
  • 基金资助:
    国家自然科学基金(81873178); 上海市浦东新区卫生和计划生育委员会重点学科主攻课题(PWZxk2017-06); 上海市高级中西医结合人才培养项目(ZY (2018-2020)-RCPY-2012); 浦东新区科技发展基金(PKJ2017-Y14)

The role and mechanisms of long non-coding RNA in liver cancer cells

Ni Zheng1, Wei Xia1,()   

  1. 1. Department of Nuclear Medicine, the Seventh People's Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200137, China
  • Received:2019-07-24 Published:2020-04-01
  • Corresponding author: Wei Xia
  • About author:
    Corresponding author: Xia Wei, Email:
引用本文:

郑妮, 夏伟. 长链非编码RNA在肝细胞肝癌发病中的作用及其机制研究进展[J/OL]. 中华细胞与干细胞杂志(电子版), 2020, 10(02): 110-114.

Ni Zheng, Wei Xia. The role and mechanisms of long non-coding RNA in liver cancer cells[J/OL]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2020, 10(02): 110-114.

肝细胞肝癌(HCC)是肝癌中最常见的病理类型,患者病死率高。对HCC发生发展机制的认知局限是其不良预后的重要原因。长链非编码RNA (LncRNA)是基因调控的重要组成部分,可通过表观遗传、转录调节和转录后调节等方式调控肝癌细胞的发生发展。近年来,LncRNA在肝癌发生发展中作用的研究逐渐深入,这为HCC早期诊断、病情控制和预后评估提供了新的方法和思路。本文就LncRNA在HCC中的研究进展作一综述。

Hepatocellular carcinoma (HCC) is the most common pathological type in liver cancer, with a high mortality rate. Lack of a comprehensive understanding of the mechanisms underlying HCC development lead to poor prognosis. Long-chain non-coding RNA (LncRNA) is an important component in gene regulation, and can regulate the occurrence and development of liver cancer cells through epigenetic, transcriptional and post-transcriptional regulation. In recent years, with the in-depth study of the role of LncRNA in the development of HCC, new methods have been provided for the early diagnosis, disease control and prognosis assessment of HCC. This article reviews the research progress of the role of LncRNA in HCC.

表1 LncRNA对肝癌细胞的调节功能
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