切换至 "中华医学电子期刊资源库"

中华细胞与干细胞杂志(电子版) ›› 2020, Vol. 10 ›› Issue (01) : 49 -51. doi: 10.3877/cma.j.issn.2095-1221.2020.01.009

所属专题: 文献

综述

尿源干细胞在泌尿生殖系统再生领域的研究进展
夏漫城1, 双卫兵2,()   
  1. 1. 030001 太原,山西医科大学第一临床医学院
    2. 030001 太原,山西医科大学第一医院泌尿外科
  • 收稿日期:2019-10-01 出版日期:2020-02-01
  • 通信作者: 双卫兵
  • 基金资助:
    山西省重点研发计划项目(201803D31103)

Recent advances of urine-derived stem cells in the regeneration of genitourinary system

Mancheng Xia1, Weibing Shuang2,()   

  1. 1. Department of First Clinical Medical College, Shanxi Medical University, Taiyuan 030001, China
    2. Department of Urology, the First Hospital of Shanxi Medical University, Taiyuan 030001, China
  • Received:2019-10-01 Published:2020-02-01
  • Corresponding author: Weibing Shuang
  • About author:
    Corresponding author: Shuang Weibing, Email:
引用本文:

夏漫城, 双卫兵. 尿源干细胞在泌尿生殖系统再生领域的研究进展[J]. 中华细胞与干细胞杂志(电子版), 2020, 10(01): 49-51.

Mancheng Xia, Weibing Shuang. Recent advances of urine-derived stem cells in the regeneration of genitourinary system[J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2020, 10(01): 49-51.

近年来,随着尿源干细胞成功从尿液中提取,人们一直在探究其在人体各系统再生领域中的应用,尤其在泌尿生殖系统再生领域的研究较多。目前文献报道可见,尿源干细胞在肾脏、输尿管、膀胱、尿道和男性生殖器官等泌尿生殖系统的再生领域展现出一定的组织重建及修复能力,其应用前景广阔,本文就尿源干细胞在泌尿生殖系统再生领域的研究进展作一述评。

In recent years, with the successful extraction of urine-derived stem cells from urine, people have been exploring its application in the regeneration field of various human systems, especially in the regeneration field of genitourinary system. Current literature reports showed that urine-derived stem cells have shown certain ability of tissue reconstruction and repair in the regeneration of genitourinary system such as kidney, ureter, bladder, urethra and male reproductive organs, and its application prospect is broad. This paper reviews the research progress of the effect of urine-derived stem cells in the regeneration of genitourinary system.

1
Choi JY, Chun SY, Ha YS, et al. Potency of human Urine-Derived stem cells for renal lineage differentiation[J]. Tissue Eng Regen Med, 2017, 14(6):775-785.
2
Qin D, Long T, Deng J, et al. Urine-derived stem cells for potential use in bladder repair[J]. Stem Cell Res Ther, 2014, 5(3):69.
3
Bharadwaj S, Liu G, Shi Y, et al. Characterization of urine-derived stem cells obtained from upper urinary tract for use in cell-based urological tissue engineering[J]. Tissue Eng Part A, 2011, 17(15/16):2123-2132.
4
Wu S, Liu Y, Bharadwaj S, et al. Human urine-derived stem cells seeded in a modified 3D porous small intestinal submucosa scaffold for urethral tissue engineering[J]. Biomaterials, 2011, 32(5):1317-1326.
5
黄英姿, 张克勤. 尿源性干细胞移植在糖尿病肾病治疗中的研究进展[J]. 重庆医学, 2017, 46(4):548-551.
6
Zhang Y, Mcneill E, Tian H, et al. Urine derived cells are a potential source for urological tissue Reconstruction[J]. J Urol, 2008, 180(5): 2226-2233.
7
Tian SF, Jiang ZZ, Liu YM, et al. Human urine-derived stem cells contribute to the repair of ischemic acute kidney injury in rats[J]. Mol Med Rep, 2017, 16(4):5541-5548.
8
赵雅培, 刘翠景, 杨翠英, 等. 人尿源干细胞移植治疗慢性肾病大鼠[J]. 中国组织工程研究, 2016, 20(32):4838-4844.
9
Dong X, Zhang T, Liu Q, et al. Beneficial effects of urine-derived stem cells on fibrosis and apoptosis of myocardial, glomerular and bladder cells[J]. Mol Cell Endocrinol, 2016, 427:21-32.
10
陶立. 低氧预处理尿源性干细胞在糖尿病肾病肾组织修复中的作用[D]. 重庆: 重庆医科大学, 2018.
11
石冬梅, 李昊, 张原元, 等. 儿童原发性肾病综合征患者尿源干细胞分离培养技术研究[J]. 中国细胞生物学学报, 2016, 38(11):1351-1357.
12
李昊, 石冬梅, 张元原, 等. 儿童原发性肾病综合征尿源干细胞生物学特征研究[J]. 重庆医科大学学报, 2018, 43(3):442-447.
13
Jiang ZZ, Liu YM, Niu X, et al. Exosomes secreted by human urine-derived stem cells could prevent kidney complications from type I diabetes in rats[J]. Stem Cell Res Ther, 2016, 7:24.
14
Zhao Z, Liu D, Chen Y, et al. Ureter tissue engineering with vessel extracellular matrix and differentiated urine-derived stem cells[J]. Acta Biomater, 2019, 88(1):266-279.
15
Li L, Jiang C, Song B, et al. Altered expression of calcium-activated K and Cl channels in detrusor overactivity of rats with partial bladder outlet obstruction[J]. BJU Int, 2008, 101(12):1588-1594.
16
Hristov KL, Afeli SA, Parajuli SP, et al. Neurogenic detrusor overactivity is associated with decreased expression and function of the large conductance voltage- and Ca(2+)-activated K(+) channels[J]. PLoS One, 2013, 8(7):e68052.
17
Wang Q, Zhao J, Wu C, et al. Large conductance voltage and Ca2+-activated K+ channels affect the physiological characteristics of human urine-derived stem cells[J]. Am J Transl Res, 2017, 9(4):1876-1885.
18
Lee JN, Chun SY, Lee HJ, et al. Human urine-derived stem cells seeded surface modified composite scaffold grafts for bladder Reconstruction in a rat model[J]. J Korean Med Sci, 2015, 30(12):1754-1763.
19
Li J, Luo H, Dong X, et al. Therapeutic effect of urine-derived stem cells for protamine/lipopolysaccharide-induced interstitial cystitis in a rat model[J]. Stem Cell Res Ther, 2017, 8(1):107.
20
Aicher WK, Hart ML, Stallkamp J, et al. Towards a treatment of stress urinary incontinence: application of mesenchymal stromal cells for regeneration of the sphincter muscle[J]. J Clin Med, 2014, 3(1):197-215.
21
Wu R, Huang C, Wu Q, et al. Exosomes secreted by urine-derived stem cells improve stress urinary incontinence by promoting repair of pubococcygeus muscle injury in rats[J]. Stem Cell Res Ther, 2019, 10(1):80.
22
张腾, 董兴有, 刘骞, 等. 尿源干细胞促进脊髓损伤后神经源性膀胱恢复[J]. 第三军医大学学报, 2016, 38(10):1073-1077.
23
Versteegden LRM, de Jonge PKJD, IntHout J, et al. Tissue engineering of the urethra: a systematic review and meta-analysis of preclinical and clinical studies[J]. Eur Urol, 2017, 72(4):594-606.
24
Ramsay S, Ringuette-Goulet C, Langlois A, et al. Clinical challenges in tissue-engineered urethral Reconstruction[J]. Transl Androl Urol, 2016, 5(2):267-270.
25
Liu Y, Ma W, Liu B, et al. Urethral Reconstruction with autologous urine-derived stem cells seeded in three-dimensional porous small intestinal submucosa in a rabbit model[J]. Stem Cell Res Ther, 2017, 8(1):63.
26
吴少峰, 张胜利, 谢华, 等. 人尿源性干细胞3-D复合生物性基质材料用于尿道下裂的组织工程重建[C]. 中华医学会第八次全国小儿外科学术会论文集, 贵阳, 2010.
27
Ouyang B, Xie Y, Zhang C, et al. Extracellular vesicles from human Urine-Derived stem cells ameliorate erectile dysfunction in a diabetic rat model by delivering proangiogenic MicroRNA[J]. Sex Med, 2019, 7(2):241-250.
28
Yang Q, Chen X, Zheng T, et al. Transplantation of human Urine-Derived stem cells transfected with pigment Epithelium-Derived factor to protect erectile function in a rat model of cavernous nerve injury[J]. Cell Transplant, 2016, 25(11):1987-2001.
29
Ouyang B, Sun X, Han D, et al. Human urine-derived stem cells alone or genetically-modified with FGF2 Improve type 2 diabetic erectile dysfunction in a rat model[J]. PLoS One, 2014, 9(3):e92825.
30
陈婉媚, 杨其运, 卞军, 等. 尿源干细胞治疗海绵体神经损伤性勃起功能障碍大鼠模型的实验研究[J]. 中华男科学杂志, 2018, 24(6):483-490.
31
刘贵华, 张弛, 谢云, 等. 尿源干细胞治疗1型糖尿病性勃起功能障碍大鼠的实验研究 [J]. 临床泌尿外科杂志, 2018, 33(8):626-632.
32
Zhou J, Wang X, Zhang S, et al. Generation and characterization of human cryptorchid-specific induced pluripotent stem cells from urine [J]. Stem Cells Dev, 2013, 22(5):717-725.
33
Deng C, Xie Y, Zhang C, et al. Urine-derived stem cells facilitate endogenous spermatogenesis restoration of busulfan-induced non-obstructive azoospermic mice by paracrine exosomes[J]. Stem Cells Dev, 2019, 28(19):1322-1333.
[1] 王岩, 马剑雄, 郎爽, 董本超, 田爱现, 李岩, 孙磊, 靳洪震, 卢斌, 王颖, 柏豪豪, 马信龙. 外泌体在骨质疏松症诊疗中应用的研究进展[J]. 中华关节外科杂志(电子版), 2023, 17(05): 673-678.
[2] 代雯荣, 赵丽娟, 李智慧. 细胞外囊泡对胚胎着床影响的研究进展[J]. 中华妇幼临床医学杂志(电子版), 2023, 19(05): 616-620.
[3] 陈山林, 魏绮珮, 刘畅. 腕关节假体:路在何方?[J]. 中华损伤与修复杂志(电子版), 2023, 18(06): 469-475.
[4] 仇申强, 王增涛, 郝丽文, 陈超, 刘林峰, 张迪. 拇手指全形再造二期整形的效果观察[J]. 中华损伤与修复杂志(电子版), 2023, 18(06): 485-490.
[5] 张健, 刘小龙, 查天建, 姚俊杰, 王傑. 富含血小板血浆联合异种脱细胞真皮基质修复糖尿病足缺血性创面的临床效果[J]. 中华损伤与修复杂志(电子版), 2023, 18(06): 503-506.
[6] 朴广昊, 李屹洲, 刘瑞, 赵建民, 王凌峰. 皮肤撕脱伤撕脱皮瓣活力早期评估与修复的研究进展[J]. 中华损伤与修复杂志(电子版), 2023, 18(06): 528-532.
[7] 张熙浩, 陈作观, 李拥军. 钝性主动脉损伤诊治的研究进展[J]. 中华损伤与修复杂志(电子版), 2023, 18(05): 438-441.
[8] 李芸, 乔栒柏, 邓华颉, 游云华. 增材制造Ti-6Al-4V钛合金种植体在牙缺失种植修复中的临床应用[J]. 中华口腔医学研究杂志(电子版), 2023, 17(05): 359-364.
[9] 叶长缨, 谢静, 丁桂聪. 乳牙龋病的过渡性治疗研究进展[J]. 中华口腔医学研究杂志(电子版), 2023, 17(05): 365-370.
[10] 王得晨, 杨康, 杨自杰, 归明彬, 屈莲平, 张小凤, 高峰. 结直肠癌微卫星稳定状态和程序性死亡、吲哚胺2,3-双加氧酶关系的研究进展[J]. 中华普通外科学文献(电子版), 2023, 17(06): 462-465.
[11] 王博, 郭利君, 李二强, 张贺林, 徐鹏, 杨晓春. 消化道与口腔黏膜组织在输尿管重建中的研究进展[J]. 中华腔镜泌尿外科杂志(电子版), 2023, 17(05): 434-439.
[12] 钟文文, 李科, 刘碧好, 蔡炳, 脱颖, 叶雷, 马波, 瞿虎, 汪中扬, 王德娟, 邱剑光. 不同比例聚乳酸/丝素蛋白复合支架在兔尿道缺损修复中的疗效[J]. 中华腔镜泌尿外科杂志(电子版), 2023, 17(05): 516-522.
[13] 王楚风, 蒋安. 原发性肝癌的分子诊断[J]. 中华肝脏外科手术学电子杂志, 2023, 12(05): 499-503.
[14] 刘卓, 段虎斌. 生物电相关疗法在神经损伤修复中的应用进展[J]. 中华神经创伤外科电子杂志, 2023, 09(05): 257-260.
[15] 王延召, 牛鹏飞, 丁长民, 高庆坤, 高兆亚, 安柯, 翟志超, 曾庆敏, 黄文生, 雷福明, 顾晋. 结直肠癌致腹壁巨大缺损的一期修补经验(附13例报告)[J]. 中华临床医师杂志(电子版), 2023, 17(05): 557-561.
阅读次数
全文


摘要