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中华细胞与干细胞杂志(电子版) ›› 2019, Vol. 09 ›› Issue (04) : 236 -241. doi: 10.3877/cma.j.issn.2095-1221.2019.04.008

所属专题: 文献

综述

间充质干细胞治疗炎症性肠病的应用及前景
李宪哲1, 谢明颢1, 练磊1,()   
  1. 1. 510655 广州,中山大学附属第六医院结直肠外科 广东省结直肠盆底疾病研究重点实验室 广东省胃肠病学研究所 国家临床重点专科-普通外科
  • 收稿日期:2019-05-31 出版日期:2019-08-01
  • 通信作者: 练磊
  • 基金资助:
    国家自然科学基金面上项目(81770557); 国家自然科学基金面上项目(81570596)

Application and prospect of mesenchymal stem cells in treatment of inflammatory bowel disease

Xianzhe Li1, Minghao Xie1, Lei Lian1,()   

  1. 1. Department of Colorectal Surgery, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangdong Institute of Gastroenterology, the Sixth Affiliated Hospital of Sun Yat-sen University, National Key Clinical Department-General Surgery, Guangzhou 510655, China
  • Received:2019-05-31 Published:2019-08-01
  • Corresponding author: Lei Lian
  • About author:
    Corresponding author:Lian Lei, Email:
引用本文:

李宪哲, 谢明颢, 练磊. 间充质干细胞治疗炎症性肠病的应用及前景[J/OL]. 中华细胞与干细胞杂志(电子版), 2019, 09(04): 236-241.

Xianzhe Li, Minghao Xie, Lei Lian. Application and prospect of mesenchymal stem cells in treatment of inflammatory bowel disease[J/OL]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2019, 09(04): 236-241.

炎症性肠病(IBD)是一种慢性非特异性肠道炎性疾病,其病因未明,有终生复发倾向,重症者迁延不愈。早期治疗以药物为主,部分重症患者后期需要手术干预。近年来,间充质干细胞(MSCs)由于具有多向分化潜能、免疫调节及组织修复功能已被广泛应用于IBD治疗的临床前基础研究中,具有一定理论基础。在已开展的MSCs治疗IBD的临床试验中,尚未有严重并发症的报道。虽然目前MSCs治疗不是IBD的标准治疗方案,但今后可能会成为一种新的治疗选择,特别是对于难治性或合并肛瘘的IBD患者。本文就MSCs的概况及其在IBD治疗的作用机制和应用前景作一综述。

Inflammatory bowel disease (IBD) is a chronic non-specific intestinal inflammatory disease, with unknown aetiology. There is a tendency to relapse throughout the life of patients with IBD and the severe cases cannot be cured. Early treatment is based on drugs, and some severe patients require surgical intervention later. In recent years, mesenchymal stem cells (MSCs) have been widely used in the experimental research of IBD treatment due to their multi-directional differentiation potential, immune regulation and tissue repair function, and it has a certain theoretical basis. In some clinical trials of MSCs for the treatment of IBD, there no serious complications have been reported and a certain therapeutic effect has been found. Currently, such stem cell therapy is not a standard of treatment regimen for IBD. However, it may potentially become a new option, especially for the IBD which is refractory or complicated with anal fistula. The purpose of this review article is to summarize the basic characteristics of MSCs, demonstrate the mechanism and application of MSCs in the therapy of IBD and prospect its trend in the future.

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